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http://dx.doi.org/10.7732/kjpr.2019.32.6.633

Combination of Grapefruit and Rosemary Extracts Has Skin Protective Effect through MMPs, MAPKs, and the NF-κB Signaling Pathway In Vitro and In Vivo UVB-exposed Model  

Yoon, Yeo-Cho (Natural F&P)
Choi, Hee-Jeong (School of Food Science & Biotechnology, Kyungpook National University)
Park, Ji-Hyun (School of Food Science & Biotechnology, Kyungpook National University)
Diniyah, Nurud (School of Food Science & Biotechnology, Kyungpook National University)
Shin, Hyun-A (Natural F&P)
Kim, Mi-Yeon (Natural F&P)
Publication Information
Korean Journal of Plant Resources / v.32, no.6, 2019 , pp. 633-643 More about this Journal
Abstract
Long-term ultraviolet (UV) exposure accelerates the phenomenon of skin photo-aging by activating collagenase and elastase. In this study, we aimed to investigate the effects of a combination of grapefruit and rosemary extracts (cG&Re) on UVB-irradiated damage in HaCaT cells and dorsal mouse skin. In HaCaT cells, cG&Re recovered UVB-reduced cell viability and inhibited protein expression of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinases (p-Erk), c-Jun N-terminal kinases (p-JNK), and a class of MAPKs (p-P38). Also, cG&Re suppressed UVB-induced collagen and elastin degradation by decreasing matrix metalloproteinases (MMPs) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) expression, which is a transcription factor. Similar results were observed in dorsal mouse skin. Taken together, our data indicate that cG&Re prevent UVB-induced skin photo-aging due to collagen/elastin degradation via activation of MAPKs, MMPs, and the NF-κB signaling pathway in vitro and in vivo.
Keywords
A combination of grapefruit and rosemary extracts (cG&Re); Matrix metalloproteinases; Mitogen-activated protein kinases; Skin photo-aging;
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