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http://dx.doi.org/10.7732/kjpr.2019.32.2.153

Effect of the Extracts from the Leaves and Branches of Sageretia thea on β-catenin Proteasomal Degradation in Human Colorectal and Lung Cancer Cells  

Kim, Ha Na (Department of Medicinal Plant Resources, Andong National University)
Park, Gwang Hun (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Kim, Jeong Dong (Department of Medicinal Plant Resources, Andong National University)
Park, Su Bin (Department of Medicinal Plant Resources, Andong National University)
Eo, Hyun Ji (Forest Medicinal Resources Research Center, National Institute of Forest Science)
Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University)
Publication Information
Korean Journal of Plant Resources / v.32, no.2, 2019 , pp. 153-159 More about this Journal
Abstract
In this study, we evaluated the effect of branch (STB) and leave (STL) extracts from Sageretia thea on ${\beta}-catenin$ level in human colorecal cancer cells, SW480 and lung cancer cells, A549. STB and STL dose-dependently suppressed the growth of SW480 and A549 cells. STB and STL decreased ${\beta}-catenin$ level in both protein and mRNA level. MG132 decreased the downregulation of ${\beta}-catenin$ protein level induced by STB and STL. However, the inhibition of $GSK3{\beta}$ by LiCl or ROS scavenging by NAC did not block the reduction of ${\beta}-catenin$ protein by STB and STL. Our results suggested that STB and STL may downregulate ${\beta}-catenin$ protein level independent on $GSK3{\beta}$ and ROS. Based on these findings, STB and STL may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer and lung cancer.
Keywords
Anticancer activity; ${\beta}-catenin$; Cancer chemoprevention; Sageretia thea;
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