Anti-inflammatory Effect of Leaves Extracts from Aralia cordata through Inhibition of NF-κB and MAPKs Signaling in LPS-stimulated RAW264.7 Cells |
Ji, Eo Hyun
(Forest Medicinal Resources Research Center, National Institute of Forest Science)
Kim, Da Som (Forest Medicinal Resources Research Center, National Institute of Forest Science) Sim, Su Jin (Forest Medicinal Resources Research Center, National Institute of Forest Science) Park, Gwang Hun (Forest Medicinal Resources Research Center, National Institute of Forest Science) Song, Jeong Ho (Forest Medicinal Resources Research Center, National Institute of Forest Science) Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University) Kim, Nahyun (Forest Medicinal Resources Research Center, National Institute of Forest Science) |
1 | Bogdan, C. 2015. Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol. 36:161-178. DOI |
2 |
Chen, X., S.A. Tang, E. Lee, Y. Qiu, R. Wang, H.Q. Duan, S. Dan, M. Jin and D. Kong. 2015. IVSE, isolated from Inula japonica, suppresses LPS-induced NO production via NF- |
3 |
Dolcet, X., D. Llobet, J. Pallares and X. Matias-Guiu. 2005. NF- |
4 | Gantke, T., S. Sriskantharajah, M. Sadowski and S.C. Ley. 2012. IkappaB kinase regulation of the TPL-2/ERK MAPK pathway. Immunol. Rev. 246:168-182. DOI |
5 |
Gloire, G., S. Legrand-Poels and J. Piette. 2006. NF- |
6 | Guzik, T.J., T. Korbut and T. Admek-Guzik. 2003. Nitric oxide and superoxide in inflammation and immune regulation. J. Physiol. Pharmacol. 54:469-487. |
7 |
Lawrence, T. 2009. The Nuclear Factor NF- |
8 |
Ha, S.K., E. Moon and S.Y. Kim. 2010. Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF- |
9 | Kang, C.H., J.R. Koo and J.S. So. 2012. Inhibitory effects of Aralia cordata Thunb. extracts in nitric oxide synthesis in RAW264.7 macrophage cells. Korean J. Food Sci. Technol. 44:621-627. DOI |
10 | Kim, H.N., S.B. Park, G.H. Park, H.J. Eo, J.H. Song, H.Y. Kwon and J.B. Jeong. 2018. Anti-inflammatory effect of the root extracts from Hibiscus syriacus in LPS-stimulated RAW264.7 cells. Korean J. Plant Res. 31:211-217. |
11 | Lim, H., H.A. Jung, J.S. Choi, Y.S. Kim, S.S. Kang and H.P. Kim. 2009. Anti-inflammatory activity of the constituents of the roots of Aralia continentalis. Arch Pharm Res. 32:1237-1243. DOI |
12 | Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051-3064. DOI |
13 |
Nishikori, M. 2005. Classical and alternative NF- |
14 | Park, G.H., J.H. Park, H.J. Eo, H.M. Song, M.H. Lee, J.R. Lee and J.B. Jeong. 2014. Anti-inflammatory effect of the extracts from Abeliophyllum distichum Nakai in LPS-stimulated RAW264.7 cells. Korean J. Plant Res. 27:209-214. DOI |
15 |
Sun, P., Zhou. K, S. Wang, P. Li, S. Chen, G. Lin, Y. Zhao and T. Wang. 2013. Involvement of MAPK/NF- |
16 | Verma, I.M., J.K. Stevenson, E.M. Schwarz, D. Van Antwerp and S. Miyamoto. 1995. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735. DOI |
17 | Surh, Y.J., K.S. Chun, H.H. Cha, S.S. Han, Y.S. Keum, K.K. Park and S.S. Lee. 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Research 480-481:243-268. DOI |
18 |
Taniguchi, K. and M. Karin. 2018. NF- |
19 | Tsuzaki, M., D. Bynum, L. Almekinders, X. Yang, J. Faber and A.J. Banes. 2003. ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells. J Cell Biochem. 1:556-562. |
20 | Wang, D. and R.N. Dubois. 2010. The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 9:781-788. |
21 | Zarghi, A. and S. Arfaei. 2011. Selective COX-2 inhibitors: A review of their structure-activity relationships. Iran J Pharm Res. 10:655-683. |
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