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http://dx.doi.org/10.7732/kjpr.2018.31.4.322

Modulative Effect of Human Hair Dermal Papilla Cell Apoptosis by Oregonin from the Braches of Alnus japonica  

Lee, Gyeong Hwa (Department of Cosmetology Science, Nambu University)
Park, Kwang Hyun (Department of Oriental Pharmaceutical Development, Nambu University)
Choi, Sun Eun (Department of Cosmetology Science, Nambu University)
Publication Information
Korean Journal of Plant Resources / v.31, no.4, 2018 , pp. 322-329 More about this Journal
Abstract
A diarylheptanoid, (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one-5-O-${\beta}$-D-xylopyranoside, named oregonin (1), was isolated from the of Alnus japonica (A. japonica), which is a species of the genus Betulaceae, growing throughout Korea, Japan and China. The structure was elucidated by various spectroscopic methods including negative and positive LC/MS, 1H-NMR, and 13C-NMR techniques or by comparison with authentic samples. In order to evaluate the anti-oxidative activities of oregonin (1) isolated from A. japonica, 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and 2,2'-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid] (ABTS) radical scavenging activity were measured in vitro. Oregonin from A. japonica exhibited potent DPPH and ABTS radical scavenging activities. A. japonica shows not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and ABTS radical scavenging activity, but also apoptosis modulative effects. The present results indicate that A. japonica could be a hair-growth-promoting agent for cosmetic products.
Keywords
Alnus japonica; Anti-oxidant; Hair growth; Oregonin;
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