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http://dx.doi.org/10.7732/kjpr.2017.30.5.535

Development of Gel Formulation Containing Alkaloid of Cacao Extract  

Kang, Sun -Young (The Faculty of Liberal Arts, Yong-In University)
Publication Information
Korean Journal of Plant Resources / v.30, no.5, 2017 , pp. 535-541 More about this Journal
Abstract
In this study, methanol (CAMe) and ethanol (CAEt) extract of Theobroma cacao L. were tested to see possibility as natural functional cosmetic agent. Cacao extract and cacao extract loaded gel were evaluated for various properties such as antioxidant, antimicrobial, cell viability, anti-inflammatory. Inhibition of nitric oxide production in lipopolysaccaride (LPS) stimulated raw 264.7cells, at concentration of $0.125{\sim}1{\mu}g/ml$ a dose-dependent manner. Gel formulation (3% extract) were stable for 60day in both extract. In conclusion, gel containing extract of Theobroma cacao L. indicated strong possibility for functional cosmetic ingredient.
Keywords
Alkaloid; Cacao; Extract; Functional cosmetics; Transdermal gel;
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1 Blois, M.S. 1958. Antioxidant determination by the use of a stable free radical. Nature 181:1199-1399.   DOI
2 Choi, M.H., Y.J. Jeon and H.J. Shin. 2015. Anthocyanin analysis of pressure-extracted Korean blueberry juice and in vitro anti-inflammatory in raw 264.7 cell line. KSBBJ. 30:191-196 (in Korean).   DOI
3 Chomnawang, M.T., S. Surassmo, V.S. Nukoolkarn and W. Gritsanapan, 2005. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J. Enthnopharmacol. 101:330-333.   DOI
4 Colven, R.M. and S.R. Pinnell. 1996. Topical vitamin C in aging. Clin. Dermatol. 14:227-234.   DOI
5 Fridovich, I. 1975. Superoxide dismutases. Annu. Rev. Biochem. 44:147-159.   DOI
6 Fischer, T.W., U.C. Hipler and P. Elsner. 2007. Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. Int J Dermatol. 46:27-35.
7 John, N.A., F. Zhong and J.M. Kebitsamang. 2012. In vitro hypoglycemic and cholesterol lowering effects of dietary fiber prepared from cocoa (Theobroma cacao L.) shells. Food Funct. 3:1044-1050.   DOI
8 Kang, S.Y., J. Kim and J.H. Kim. 2014. Manufacture & evaluation of mascara containing Theobroma cacao L. J. Kor. Soc. Cosm. 20:713-720 (in Korean).
9 Karim, A.A., A. Aziant, A. Ismail, P. Hashim, S.S.A. Gani, B.H. Zainudian and N.A. Abdullah. 2014. Phenolic composition, antioxidant, anti-wrinkles and tyrosinase inhibitory activities of cocoa pod extract. BMC Complement Altern Med. 14:381-394.   DOI
10 Nam, J.H., J.T. Seo, Y.H. Kim, K.D. Kim, D.L. Yoo, J.N. Lee, S.Y. Hong, S.J. Kim, H.B. Sohn, H.S. Kim, B.S. Kim, J.S. Shin, K.T. Lee and H.J. Park. 2015. Inhibitory effects of extracts from Arabis glabra on lipopolysaccharide induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Korean J. Plant Res. 28(5):568-573 (in Korean).   DOI
11 Smit, H.J., E.A. Gaffan and P.J. Rogers. 2004. Methylxanthines are the psycho-pharmacologically active constituents of chocolate. Psychopharmacology (Berl) 176:412-419.   DOI
12 Rusconi, M. and A. Conti. 2010. Theobroma cacao L., the food of the Gods. A scientific approach beyond myths and claims. Pharmacol Res. 61:5-13.   DOI
13 Scapagnini, G., S. Davinelli, L.D. Renzo, A.D. Lorenzo, H.H. Olarte, G. Micali, A.F. Cicero and S. Gonzalez. 2014. Cocoa bioactive compounds: significance and potential for the maintenance of skin health. Nutrients 6:3202-3213.   DOI
14 Smit, H.J. and R.J. Blackburn. 2005. Reinforcing effects of caffeine and theobromine as found in chocolate. Psychopharmacology (Berl) 181:101-106.   DOI