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http://dx.doi.org/10.7732/kjpr.2017.30.2.125

Red Ginseng Extract Improves Liver Fibrosis in Mice Treated with the Endocrine Disruptor Bisphenol A  

Choi, Jehun (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA)
Park, Chun Geon (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA)
Seo, Kyoung Hee (Department of Biomedical Chemistry, Konkuk University)
Kim, Hyung Don (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA)
Yoon, Ji Hye (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA)
Ahn, Young Sup (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA)
Kim, Jin Seong (Department of Biomedical Chemistry, Konkuk University)
Publication Information
Korean Journal of Plant Resources / v.30, no.2, 2017 , pp. 125-132 More about this Journal
Abstract
Bisphenol A (BPA), a known endocrine disruptor, induces toxicity in cells and in experimental animals. Ginseng extracts were evaluated to determine whether they can inhibit BPA-induced toxicity. The antioxidant activity of fresh ginseng extract (WGE), dried white ginseng extract (DGE), and dried red ginseng extract (RGE) was measured using the DPPH assay. WGE and RGE increased DPPH free radical scavenging activity. Cell viability was measured in HepG2 cells following treatment with BPA and ginseng extracts using the MTT assay. DGE and RGE increased HepG2 cell viability following treatment with $200{\mu}M$ BPA. RGE reduced levels of biochemical markers of liver damage, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) that increased in mice following treatment with BPA. In addition, the regeneration and proliferation of damaged liver cells were significantly increased in RGE-treated mice. Moreover, RGE inhibited hepatic fibrosis in the surrounding area and in the central vein of the liver microstructure. RGE also significantly inhibited BPA-induced cytotoxicity. In addition, RGE protected liver damage and regenerated liver tissues in BPA-treated animals. These results show that RGE may represent a potential candidate drug for the treatment and prevention of liver damage caused by environmental toxins.
Keywords
Panax ginseng C.A. Mey.; Bispheonol A; Korean red ginseng; Liver protection;
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Times Cited By KSCI : 9  (Citation Analysis)
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