Red Ginseng Extract Improves Liver Fibrosis in Mice Treated with the Endocrine Disruptor Bisphenol A
![]() |
Choi, Jehun
(Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA)
Park, Chun Geon (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA) Seo, Kyoung Hee (Department of Biomedical Chemistry, Konkuk University) Kim, Hyung Don (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA) Yoon, Ji Hye (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA) Ahn, Young Sup (Herbal Crop Utilization Research Team, National Institute of Horticultural and Herbal Science, RDA) Kim, Jin Seong (Department of Biomedical Chemistry, Konkuk University) |
1 | Kim, H.Y., K.S. Kang, N. Yamabe and T. Yokozawa. 2008. Comparison of the effects of Korean ginseng and heat-processed Korean ginseng on diabetic oxidative stress. Am. J. Chin. Med. 36:989-1004. DOI |
2 | Kretschmer, X.C. and W.S. Baldwin. 2005. CAR and PXR: xenosensors of endocrine disrupters? Chem. Biol. Interact. 155:111-128. DOI |
3 | Lee, D.H. 2012. Endocrine disrupting chemicals and environmental diseases. J. Korean Med. Assoc. 55:243-249. DOI |
4 | Lee, H.J., Y.H. Lee, S.K. Park, E.S. Kang, H.J. Kim, Y.C. Lee, C.S. Choi, S.E. Park, C.W. Ahn and B.S. Cha. 2009. Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism 58:1170-1177. DOI |
5 | Lee, J.S., G.N. Kim and H.D. Jang. 2008. Effect of Red Ginseng Extract on Storage and Antioxidant Activity of Tofu. J. Korean Soc. Food Sci. Nutr. 37:1497-1509. DOI |
6 | Lee, S., M.S. Lee, C.T. Kim, I.H. Kim and Y. Kim. 2012a. Ginsenoside Rg3 reduces lipid accumulation with AMP-activated protein kinase (AMPK) activation in HepG2 cells. Int. J. Mol. Sci. 13:5729-5739. DOI |
7 | Lee, S.H., H.J. Lee, Y.H. Lee, B.W. Lee, B.S. Cha, E.S. Kang, C.W. Ahn, J.S. Park, H.J. Kim and E.Y. Lee. 2012b. Korean red ginseng (Panax ginseng) improves insulin sensitivity in high fat fed Sprague-Dawley rats. Phytother. Res. 26:142-147. DOI |
8 | Olaso, E. and S.L. Friedman. 1998. Molecular regulation of hepatic fibrogenesis. J. Hepatol. 29:836-847. DOI |
9 | Park, H.J., D.H. Jung, H. Joo, N.S. Kang, S.A. Jang, J.G. Lee and E.H. Sohn. 2010. The comparative study of anti-allergic and anti-inflammatory effects by fermented red ginseng and red ginseng. Korean J. Plant Res. 23:415-422. |
10 | Quan, H.Y., H.D. Yuan, M.S. Jung, S.K. Ko, Y.G. Park and S.H. Chung. 2012. Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice. Int. J. Mol. Med. 29:73-80. |
11 | Seo, E.Y. and W.K. Kim. 2011. Red ginseng extract reduced metastasis of colon cancer cells in vitro and in vivo. J. Ginseng. Res. 35:315-324. DOI |
12 | Sohn, E.H., J.W. Yoon, H.J. Koo, D.W. Park, Y.J. Jeong, S. Namkoong, H.S. Han and S.C. Kang. 2012. Immunomodulating effects of red ginseng on the regulation of cytokine release in vivo. Korean J. Plant Res. 25:578-585. DOI |
13 | Sung, S.K., Y.K. Rhee, C.W. Cho, Y.C. Kim, O.H. Lee and H.D. Hong. 2013. Physicochemical properties and antioxidative activity of fermented Rhodiola sachalinensis and Korean red ginseng mixture by Lactobacillus acidophilus. Korean J. Food. Nutr. 26:358-365. DOI |
14 | Svegliati Baroni, G., L. D'Ambrosio, G. Ferretti, A. Casini, A. Di Sario, R. Salzano, F. Ridolfi, S. Saccomanno, A.M. Jezequel and A. Benedetti. 1998. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 27:720-726. DOI |
15 | Vandenberg, L.N., M.V. Maffini, C. Sonnenschein, B.S. Rubin and A.M. Soto. 2009. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr. Rev. 30:75-95. DOI |
16 | Wang, L., J. Hao, J. Hu, J. Pu, Z. Lü, L. Zhao, Q. Wang, Q. Yu, Y. Wang and G. Li. 2012. Protective effects of ginsenosides against bisphenol A-induced cytotoxicity in 15P-1 sertoli cells via extracellular signal-regulated kinase 1/2 signalling and antioxidant mechanisms. Basic Clin. Pharmacol. Toxicol. 111:42-49. |
17 | Bang, C.S., S.H. Hong, K.T. Suk, J.B. Kim, S.H. Han, H. Sung, E.J. Kim, M.J. Kim, M.Y. Kim and S.K. Baik. 2014. Effects of Korean red ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut-liver axis of alcoholic liver disease. J. Ginseng Res. 38:167-172. DOI |
18 | Xu, Y., M. Rojkind and M.J. Czaja. 1996. Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells. Gastroenterology 110:1870-1877. DOI |
19 | Abdel-Wahhab, M.A., N.S. Hassan, A.A. El-Kady, Y.A. Khadrawy, A.A. El-Nekeety, S.R. Mohamed, H.A. Sharaf and F.A. Mannaa. 2010. Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats. Food. Chem. Toxicol. 48:733-742. DOI |
20 | Baillie-Hamilton, P.F. 2002. Chemical toxins: a hypothesis to explain the global obesity epidemic. J. Altern. Complement Med. 8:185-192. DOI |
21 | Blois, M.S. 1958. Antioxidant determinations by the use of a stable free radical. Nature 181:1199-1200. DOI |
22 | Di Sario, A., E. Bendia, G.S. Baroni, F. Ridolfi, A. Casini, E. Ceni, S. Saccomanno, M. Marzioni, L. Trozzi and P. Sterpetti. 2002. Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production. J. Hepatol. 37:584-591. DOI |
23 | Hwang, E.K. 2013. Protective effect of rutin on carbon tetrachloride-Induced acute hepatotoxicity in rats. J. Vet. Clin. 30:12-16. |
24 | Diamanti-Kandarakis, E., J.-P. Bourguignon, L.C. Giudice, R. Hauser, G.S. Prins, A.M. Soto, R.T. Zoeller and A.C. Gore. 2009. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr. Rev. 30:293-342. DOI |
25 | Grun, F. and B. Blumberg. 2006. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology 147:s50-s55. DOI |
26 | Heo, J.H., S.T. Lee, M.J. Oh, H.J. Park, J.Y. Shim, K. Chu and M.H. Kim. 2011. Improvement of cognitive deficit in Alzheimer's disease patients by long term treatment with Korean red ginseng. J. Ginseng Res. 35:457-461. DOI |
27 |
Hwang, J.T., M.S. Lee, H.J. Kim, M.J. Sung, H.Y. Kim, M.S. Kim and D.Y. Kwon. 2009. Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR- |
28 | Jenkins, S., A. Grandison, J. Baxter, D. Day, I. Taylor and R. Shields. 1985. A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat. J. Hepatol. 1:489-499. DOI |
29 | Kaneko, H. and K. Nakanishi. 2004. Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically, its anti-stress action for prevention of disease. J. Pharmacol. Sci. 95:158-162. DOI |
30 | Kavlock, R.J., G.P. Daston, C. DeRosa, P. Fenner-Crisp, L.E. Gray, S. Kaattari, G. Lucier, M. Luster, M.J. Mac and C. Maczka. 1996. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the US EPA-sponsored workshop. Environ. Health. Persp. 104:715. DOI |
31 | Ki, S.H., J.H. Yang, S.K. Ku, S.C. Kim, Y.W. Kim and I.J. Cho. 2013. Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis. J. Ginseng Res. 37:45-53. DOI |
![]() |