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http://dx.doi.org/10.7732/kjpr.2016.29.5.532

Effects of a Caragana sinica Water Extract on Lipid and Glucose Metabolism in Ovariectomized Rats  

Lee, Sang Chul (School of Applied Biosciences, Kyungpook National University)
Chung, Soo Im (Department of Food Science and Nutrition, Kyungpook National University)
Kang, Mi Young (Department of Food Science and Nutrition, Kyungpook National University)
Publication Information
Korean Journal of Plant Resources / v.29, no.5, 2016 , pp. 532-538 More about this Journal
Abstract
Menopause is characterized by a decrease in estrogen production by the ovaries. Furthermore, the risk of developing chronic diseases including cardiovascular disease, obesity, and diabetes increases in menopausal women. In this study, we evaluated the ability of Caragana sinica (CS) to affect lipid and glucose metabolism in an ovariectomized Sprague-Dawley rat model of induced menopause. The animals were divwided randomly into three groups: sham-operated rats (SHAM), ovariectomized rats (OVX), and ovariectomized rats treated with 1% water extract of CS (OVX-CS). The OVX-CS treated mice showed a significant decrease in body weight, adipose tissue, triglyceride, and total cholesterol. Improved lipid and glucose profiles were also observed, and were attributed to suppression of hepatic lipogenesis and adipokine production and regulation of glucose-regulating enzyme activity. Therefore, these findings indicate a potential use for CS as a functional food for menopause-induced hyperlipidemia and hyperglycemia.
Keywords
Caragana sinica; Glucose metabolism; Lipid metabolism; Menopause; Ovariectomized rat;
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1 Park, H.S., K.C. Yang and K.M. Yang. 2009. The effects of medicinal herb-made Sikhe on damage and lipid levels of liver in rats fed high-cholesterol diets. J. Life Sci. 19:1104-1111 (in Korean).   DOI
2 Pitkanen, E., O. Pitkanen and L. Uotila. 1997. Enzymatic determination of unbound D-mannose in serum. Eur. J. Clin. Chem. Clin. Biochem. 35:761-766.
3 Reitman, S. and S. Frankel. 1957. A colorimetric method for the determination of serum glutamate oxaloacetate transaminases. AM. J. Clin. Pathol. 28:56-63.   DOI
4 Seifter, S., S. Dayton, B. Navic and E. Muntwyler. 1950. The estimation of glycogen with the anthrone reagent. Arch. Biochem. 25:191-200.
5 Seung, H.K. and I.H. Kim. 1978. Sterol composition of Caragana Sinica study. Korea. J. Parmacog. 22:219-223 (in Korean).
6 Shin, J.H., M.J. Kang, S.M. Yang, S.J. Lee and N.J. Sung. 2011. Effects of Namhae specialized crops water extract on lipid metabolism in rats fed a cholesterol diet. Korean J. Food Cookery Sci. 27:599-610 (in Korean).   DOI
7 Stark, K.D. and B.J. Holub. 2004. Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. Am. J. Clin. Nutr. 79:765-773.   DOI
8 Yamazaki, K and Murata, M. 1990. Frequency of atherogenic risk factors in Japanese obese children. Diabetes Res. Clin. Pract. 10: S211-S219.   DOI
9 Chu, S.H., M.K. Lee, K. Jill, B. Jenny and S. Dorie. 2008. Effect of estrogen on ovariectomy-induced obesity in rats. J. Korean Biol. Nurs. Sci. 10:80-87 (in Korean).
10 Chung, S.I., C.W. Rico and M.Y. Kang. 2014. Comparative study on the hypoglycemic and antioxidative effects of fermented paste (Doenjang) prepared from soybean and brown rice mixed with rice bran or red ginseng marc in mice fed with high fat diet. Nutrients 6:4610-4624.   DOI
11 Gwak, J.H. and I.H. Kim. 1974. The studies on the anti-inflammatory activity of Caragana Sinica root. Korea. J. Parmacog. 5:179-185 (in Korean).
12 Davidson, A.L. and W.J. Arion. 1987. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: Physiological implications of higher cellular activity. Arch. Biochem. Biophys. 253:156-167.   DOI
13 Gaspard, U.J., J.M. Gottal and F.A. van den Brûle. 1995. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas 21:171-178.   DOI
14 Geer, B.W., D. Krochko, M.J. Oliver, V.K. Walker and J.H. Williamson. 1980. Enzymatic assay of malic enzyme. Comp. Biochem. Physiol. 65B:25-34.
15 Hwang, G.J. and U.H. Kim. 1983. Aanti-inflammatory and analgesic activities of the root of Caragana Sinica root. Korea. J. Parmacog. 14:140-146(in Korean).
16 Jeon, Y.S., B.S. Jo, H.J. Park, S.A. Kang and Y.J. Cho. 2012. Screening of biological activity of Caragana Sinica extracts. J. Korean Soc. Food Sci. Nutr. 41:1211-1219 (in Korean).   DOI
17 Alegre, M., C.J. Ciudad, C. Fillat and J.J. Guinovart. 1988. Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal. Biochem. 173:185-189.   DOI
18 Lazarow, P.B. 1987. Assay of peroxisomal beta-oxidation of fatty acids. Methods Enzymol. 72:315-319.
19 Kim, J.H., J.Y Lee, B.Y. Lee, C.Y. Yoon and M.H. Kim. 2010. The vascular plants in Mt. Gaji (Gyeongsang nam-do). Korean J. Plant Res. 23(4):302-326 (in Korean).
20 Kim, J.Y., K.J. Jo, O.S. Kim, B.J. Kim, D.W. Kang, K.H. Lee, H.W. Baik, M.S. Han and S.K. Lee. 2010. Parenteral 17beta-estradiol decreases fasting blood glucose levels in non-obese mice with short-term ovariectomy. Life Sci. 87:358-356.   DOI
21 Lee, S.D. and I.H. Kim. 1992. Studies on the active ingredient Caragana Sinica roots. Chungang Univ. Thesis 35:1-29 (in Korean).
22 Lee, S.W., M.R, Kim and Y.O. You. 2009. Adipokines, the obesity and metabolic complications in the postmenopausal women. Korean J. Obstet. Gynecol. 52:1204-1211 (in Korean).
23 Lee, Y.B. and S.S. Kang. 1990. Saponins from the roots Caragana Sinica. Korea. J. Parmacog. 21:193-199 (in Korean).
24 Leveille, G.A. and R.W. Hanson. 1966. Adaptive changes in enzyme activity and metabolic pathways in adipose tissue from meal-fed rats. J. Lipid Res. 7:46-55.
25 Meli, R., M. Pacilio, G.M. Raso, E. Esposito, A. Coppola, C.D. Carlo, C. Nappi and R.D. Carlo. 2004. Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats. Endocrinology 145:3115-3121.   DOI
26 Ochoa, S. 1955. Malic dehydrogenase from pig heart: In Colowick, S.P. and N.E. Kaplan (eds.), Methods in Enzymology, Academic Press, New York, NY (USA). pp. 735-739.
27 Park, C.Y. and K.E. Hong. 2008. A study on the effect of herbal-acupuncture with HK-1000 solution on hyperlipidemia and arteriosclerosis induced rats. J. Pharmacopuncture 11:55-66 (in Korean).