Browse > Article
http://dx.doi.org/10.7732/kjpr.2016.29.3.289

Immune Cells Activity, Nitrite Scanvenging and ABTS Radical Scavenging Activities of Codonopsis lanceolata Ethanol Extracts from Districts in Korea  

Boo, Hee-Ock (WELLPHYTO Co. Ltd., BI Center, GIST)
Park, Jeong-Hun (WELLPHYTO Co. Ltd., BI Center, GIST)
Kim, Hong-Gi (Biological Control Center, Jeonnam Provincial College)
Kim, Hag-Hyun (Faculty of Food Nutrition and Cookery, Woosong Information College)
Kwon, Soo-Jeong (Faculty of Food Nutrition and Cookery, Woosong Information College)
Seo, Dong-Yeon (Department of Hotel and Restaurant Culinary Art, Kunjang University)
Lee, Moon-Soon (Department of Industrial Plant Science & Technology, Chungbuk National University)
Publication Information
Korean Journal of Plant Resources / v.29, no.3, 2016 , pp. 289-296 More about this Journal
Abstract
This study was executed to evaluate the immune activity, nitrite scavenging activity and ABTS radical scavenging activity against extracts of various concentration of ethanol solvent from Codonopsis lanceolata cultured at 6 local regions. The immune responses from both human T and B cell line was significantly enhanced in the cell growth compared to control while the cell growth was influenced at a certain period of culture. The results revealed that the cell growth of both human T and B cell was altered in a time dependent manner. The nitrite scavenging activity of ethanol extracts from various solvent concentration of C. lanceolata were affected by pH. At a pH of 1.2, the nitrite scavenging effect of all of the extracts tested observed higher than that of the other two pH ranges. There was no distinct detection of nitrite scavenging effects of the pH range 6.0. The ABTS radical scavenging activity was progressively increased in a dose-dependent manner, and the activity was the highest in 100% ethanol extract. The result from this investigation suggests that the extract of Codonopsis lanceolata could be an addition to basic medicine for immune modulation and natural food additives.
Keywords
Immune activity; Nitrite Scavenging Activity; ABTS radical scavenging activity; Codonopsis lanceolata;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 Kato, H., I.E. Lee, N. Van Chuyen, S.B. Kim and F. Hayase. 1987. Inhibition of nitrosamine formation by nondialyzable melanoidins. Agr. Biol. Chem. 51:1333-1338.
2 Paul, D.J., N.B. Laure, S.K. Guru, I.A. Khan, S.K. Ajit, R.A. Vishwakarma and T. Pierre. 2014. Antiproliferative and antimicrobial activities of alkylbenzoquinone derivatives from Ardisia kivuensis. Pharm. Biol. 52.
3 Lee, J.Y., W.I. Hwang and S.T. Lim. 2004. Antioxidant and anticancer activities of organic extracts from Platycodon grandiflorum De candolle roots. J. Ethnopharmacol. 93:409-415.   DOI
4 Noh, B.Y., H.J. Lee, J.R. Do and H.K. Kim. 2014. Antioxidant and ACE inhibitory activity of cultivated and wild Angelica gigas Nakai extracts prepared using different extraction conditions. Prev. Nutr. Food Sci. 19:274.   DOI
5 Park, Y.J., G.Y. Cheon, H.W. Song, C.S. Shin, Y.G. Ku, N.R. Kang and B.G. Heo. 2016. Mineral composition and physiological activities of methanol extract from the seeds of Persicaria tinctoria. Korean J. Plant Res. 29(1):032-038.   DOI
6 Pittella, F., R.C. Dutra, D.D. Junior, M.T. Lopes and N.R. Barbosa. 2009. Antioxidant and cytotoxic activities of Centella asiatica (L) Urb. Int. J. Mol. Sci. 10:3713-3721.   DOI
7 Re, R., N. Pellegrini, A. Proteggente, A. Pannala, M. Yang and C.R. Evans. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Bio. Med. 26(9-10):1231-1237.   DOI
8 Hong, T.G., Y.R. Lee, M.H. Yim and C.N. Hyun. 2004. Physiological functionality and nitrite scavenging ability of fermentation extracts from pine needles. Korean J Food Preserv. 11:94-99.
9 Choi, D.B., K.A. Cho, M.S. Na, H.S. Choi, Y.O. Kim, D.H. Lim, S.J. Cho and H. Cho. 2008. Effect of bamboo oil on antioxidative activity and nitrite scavenging activity. J. Ind. Eng. Chem. 14:765-770.   DOI
10 Foyer, C.H., P. Descourvières and K.J. Kunert. 1994. Protection against oxygen radicals: an important defence mechanism studied in transgenic plants. Plant Cell Env. 17:507-523.   DOI
11 Guizani, N., M.I. Waly, V. Singh and M.S. Rahman. 2013. Nabag (Zizyphus spina-christi) extract prevents aberrant crypt foci development in colons of azoxymethane-treated rats by abrogating oxidative stress and inducing apoptosis. Asian Pac J Cancer Prev. 14:5031-5035.   DOI
12 Isaykina, N., T. Perevozchicova and G. Kalinkina. 2008. Immunotropic activity of plant extract echinosol. B. Exp. Biol. Med. 146:223-225.   DOI
13 Janeway, C.A., P. Travers, M. Walport and J.D. Capra. 1999. Immunobiology: the immune system in health and disease. Current Biology Publications New York, NY (USA).
14 Joh, E.H., I.A. Lee, S.J. Han, S.J. Chae and D.H. Kim. 2010. Lancemaside A ameliorates colitis by inhibiting NF-jB activation in TNBS-induced colitis mice. Int. J. Colorectal Dis. 25:545-551.   DOI
15 Boora, F., E. Chirisa and S. Mukanganyama. 2014. Evaluation of Nitrite Radical Scavenging Properties of Selected Zimbabwean Plant Extracts and Their Phytoconstituents. J. Food Process.
16 Kang, M.Y., S.H. Lee, S.W. Cha, J.L. Song and S.C. Lee. 2015. Effect of Achyranthis radix and Drynariae rhizome extracts on antioxidant activity and antioxidant enzymes. Korean J. Plant Res. 28(5):600-607.   DOI
17 Shin, J.H., J.Y. Lee, J.C. Ju, S.J. Lee, H.S. Cho and N.J. Sung. 2005. Chemical properties and nitrite scavenging ability of citron (Citrus junos). J. Korean Soc. Food Sci. Nutr. 34:496-502.   DOI
18 Wang, L., M.L. Xu, J.H.u, S.K. Rasmussen and M.H. Wang. 2011. Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells - Involvement of ROS generation and polyamine depletion. Food Chem. toxicol. 49:149-154.   DOI
19 Buckley, R.H., S.E. Schiff, R.I. Schiff, M.L. Markert, L.W. Williams, J.L. Roberts, L.A. Myers and F.E. Ward. 1999. Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. New Engl. J. Med. 340:508-516.   DOI