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http://dx.doi.org/10.7732/kjpr.2015.28.6.704

Safflower Bud Dietary Prevents Ovariectomy-induced Osteoporosis in Rats  

Choi, Joo Hee (Department of Veterinary Physiology, Chonnam National University)
Lim, Seul Ki (Metabolism and Functionality Research Group, R&D division, World Institute of Kimchi)
Jang, Ah Ra (Department of Veterinary Physiology, Chonnam National University)
Nho, Jong Hyun (Department of Veterinary Physiology, Chonnam National University)
Lim, Jae Oh (Department of Veterinary Physiology, Chonnam National University)
Cho, Seong Kang (Department of Veterinary Physiology, Chonnam National University)
Kim, Young Kuk (R&D team, Dasan Institute of Life & Science Co. Ltd.)
Lee, An Chul (R&D team, Dasan Institute of Life & Science Co. Ltd.)
Choi, Mi Young (R&D team, Dasan Institute of Life & Science Co. Ltd.)
Boo, Young Min (Department of Herbology, Kyung Hee University)
Park, Soo Hyun (Department of Veterinary Physiology, Chonnam National University)
Publication Information
Korean Journal of Plant Resources / v.28, no.6, 2015 , pp. 704-709 More about this Journal
Abstract
Safflower (Carthamus tinctorius L.) seeds have long been clinically used in Korea to promote bone formation and prevent osteoporosis. In addition, the safflower buds (SB) were found to have more useful functional ingredients than safflower seed. Thus, we investigated the preventive effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus 17β-estradiol (E2 10 μg/kg, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 3%) to OVX rats markedly increased trabecular formation in femur compared to OVX rats. Feeding of SB diet (0.3% or 3%) to OVX rats also decreased TRAP activity compared to OVX rats. These results suggest that SB diets have bone sparing effects by the decrease of osteoclast activity. We also observed that OVX rats fed with SB diet (0.3% or 3%) exhibited the decrease of calcium and phosphorus in serum compared to OVX-induced rats. Therefore, SB may be beneficial for the patients of osteoporosis, especially in postmenopausal women.
Keywords
Ovariectomized rats; Safflower bud; Osteoporosis; Osteoclast;
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