Triglyceride Control Effect of Agrimonia eupatoria L. in Oleic Acid Induced NAFLD-HepG2 Model
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Sohn, Eun-Hwa
(Department of Herbal Medicine Resource, Kangwon National University)
Kim, Taeseong (Department of Herbal Medicine Resource, Kangwon National University) Jeong, Yong Joon (Department of Life Science, Gachon University) Han, Hyo-Sang (Department of Health Administration, Joongbu University, Geumsan 32713, Korea) Lea, Youngsung (BIOKOREA CO., LTD.) Cho, Young Mi (Department of Life Science, Gachon University) Kang, Se Chan (Department of Life Science, Gachon University) |
1 | Ye, J.M., P.J. Doyle, M.A. Iglesias, D.G. Watson, G.J. Cooney and E.W. Kraegen. 2001. Peroxisome proliferator activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation. Diabetes 50:411-417. DOI |
2 | Yoo, J. and J. Lee. 2010. Effects of Saenggantanggami-bang on nonalcoholic fatty liver disease model induced by fatty acids. Korean J. Orient Int. Med. 31(2):143-157. |
3 | Yun, K.S., H.J. Woo, J.H. Lee and Y.C. Kim. 2009. Effect of Injinchunggan-tang & Injinsaryung-san on NASH induced by MCD-diet in A/J mice. Korean J. Orient Int. Med. 30(2):410-421. |
4 | Zhu, L., J. Tan, B. Wang, R. He, Y. Liu and C. Zheng. 2009. Antioxidant activities of aqueous extract from Agrimonia pilosa Ledeb and its fractions. Chem. Biodivers. 6:1716-1726. DOI |
5 | Lapsys, N.M., A.D. Kriketos, M. Lim-Frase, A.M. Poynten, A. Lowy, S.M. Furler, D.J. Chisholm and G.J. Cooney. 2000. Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle. J. Clin. Endocrinol. Metab. 85:4293-4297. |
6 | Lee, J.A., E.K. Ahn, S.S. Hong and J.S. Oh. 2012. Anti-obesity effect of ethyl acetate extracts from Agrimonia pilosa Ledeb. in 3T3-L1 preadipocytes. J. Korean Soc. Food Sci. Nutr. 41(2):161-167. DOI |
7 | Ludwig, J., T.R. Viggiano, D.B. Mcgill and B.J. Oh. 1980. Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. 55:434-438 |
8 | Park, M.Y., H.H. Jang, J.Y. Lee, Y.M. Lee, J.H. Kim, J.H. Park and D.S. Park. 2012. Effect of Hog Millet supplementation on hepatic steatosis and insulin resistance in mice fed high-fat diet. J. Korean Soc. Food Sci. Nutr. 41(4):501-509. DOI |
9 | Rosen, E.D., C.J. Walkey, P. Puigserver and B.M. Spiegelman. 2000. Transcriptional regulation of adipogenesis. Genes & Dev. 14:1293-1307. |
10 | Smith, B.W. and L.A. Adams. 2011. Non-alcoholic fatty liver disease. Crit Rev Clin Lab Sci. 48:97-113. DOI |
11 | Sung, T.S. and G.M. Son. 1994. Effect of Cnidi rhizome boiling extract solution on enzyme and hormone of plasma, and liver in the fatted rats induced by high fat dietary. Korean J. Food & Nutrition 7(2):108-113. |
12 | Wang, S., H.N. Song, W.I. Choi, J.H. Park, Y.J. Jeong, S.C. Kang, S.K. Ko and D.H. Bhang. 2012. Identification of anti-obesity constituents from Yukeuigambitang. Korean J. Plant Res. 25(2):271-276. DOI |
13 | Kato, H., W. Li, M. Koike, Y. Wang and K. Koike. 2001. Phenolic glycosides from Agrimonia pilosa. Phytochemistry 71:1925-1929. |
14 | Hashimoto, T., W.S. Cook, C. Qi, A.V. Yeldandi, J.K. Reddy and M.S. Rao. 2000. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J. Biol. Chem. 275:28918-28928. DOI |
15 | Ivanova, D., D. Vankova and M. Nashar. 2013. Agrimonia eupatoria tea consumption in relation to markers of inflammation, oxidative status and lipid metabolism in healthy subjects. Arch. Physiol. Biochem. 119:32-37. DOI |
16 | Jeon, T., S.G. Hwang, S. Hirai, T. Matsui, H. Yano, T. Kawda, B.U. Lim and D. Ki. 2004. Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sci. 75:3195-3203. DOI |
17 | Kim, S.M., D.K. Yoon, B.S. Yang and K.H. Cho. 2005. An activation of peroxisome proliferator-activated receptor δ attenuate alcoholic liver disease and nonalcoholic fatty liver disease in rats. J. Korean Soc. Food Sci. Nutr. 14(1):29-38. |
18 | Kim, S.M., J.A. Kim, J.H. Han, K.H. Cho and D.K. Yoon. 2006. Nonalcoholic fatty liver disease and metabolic syndrome in nonobese, Nondiabetic adults. J. Korean Soc. Study Obes. 15:(1) 44-51. |
19 | Kliewer, S.A. and T.M. Wilson. 1998. The nuclear receptor PPAR-γ: bigger than fat. Curr. Opin. Genet. Dev. 8:576-581. DOI |
20 | Kwon, D.H., H.Y. Kwon, H.J. Kim, E.J. Chang, M.B. Kim, S.K. Yoon, E.Y. Song, D.Y. Yoon, Y.H. Lee, I.S. Choi and Y.K. Choi. 2005. Inhibition of hepatitis B virus by an aqueous extract of Agrimonia eupatoria L. Phytother Res. 19:355-358. DOI |
21 | Correia, H.S., M.T. Batista and T.C. Dinis. 2007. The activity of an extract and fraction of Agrimonia eupatoria L. against reactive species. Biofactors 29:91-104. DOI |
22 | An, R.B., H.C. Kim, G.S. Jeong, S.H. Oh, H. Oh and Y.C. Kim. 2005. Constituents of the aerial parts of Agrimonia pilosa. J Nat Prod. 11:196-199. |
23 | Choi, M.Y., H.J. Woo, Y.C. Kim and J.H. Lee. 2009. Effects of gamisaenggan-tang on high fat diet-induced nonalcoholic fatty liver disease. Korean J. Orient Int. Med. 30(2):365-374. |
24 | Comelius, P., O.A. MacDougald and M.D. Lane. 1994. Regulation of adipocyte development. Annu Rev Nutr. 14:99-129. DOI |
25 | Cwikla, C., K. Schmidt, A. Matthias, K.M. Bone, R. Lehmann and E. Tiralongo. 2010. Investigations into the antibacterial activities of phytotherapeutics against Helicobacter pylori and Campylobacter jejuni. Phytother Res. 24:649-656. |
26 | Gray, A. M. and P. R. Flatt. 1998. Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion. Br. J. Nutr. 80(1):109-114. DOI |
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