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http://dx.doi.org/10.7732/kjpr.2015.28.3.305

Antioxidant, Anti-inflammatory and Cytotoxicity on Human Lung Epithelial A549 Cells of Jerusalem artichoke (Helianthus tuberosus L.) Tuber  

Zhang, Qin (Department of Medical Biotechnology, Kangwon National University)
Kim, Hye-Young (Department of Dental Hygiene, Kangwon National University)
Publication Information
Korean Journal of Plant Resources / v.28, no.3, 2015 , pp. 305-311 More about this Journal
Abstract
This study investigated in vitro antioxidant, anti-inflammatory and cytotoxicity on human lung epithelial A549 cells of different solvent extracts from Jerusalem artichoke (Helianthus tuberosus L.) tuber. The EtOH extract contained amounts of phenolics (22.20 tannic acid equivalent ㎎/ɡ) and exhibited the highest antioxidant activity and anti-inflammatory activity. Several methods were employed for measure the antioxidant activity: 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity (IC50 = 206.79 ㎍/㎖), reducing power activity (21.26 ascorbic acid equivalent ㎎/ɡ) and total antioxidant activity (19.05 ascorbic acid equivalent ㎎/ɡ). Meantime, the EtOH extract inhibited the NO production completely with a concentration of 800 ㎍/㎖. Besides, the H2O extract exhibited more potent effect on human lung epithelial A549 cells. This study suggested that Jerusalem artichoke tuber had antioxidant, anti-inflammatory and cytotoxicity on human lung epithelial A549 cells.
Keywords
Jerusalem artichoke tuber; Antioxidant; Anti-inflammatory; Cytotoxicity;
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Times Cited By KSCI : 6  (Citation Analysis)
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