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http://dx.doi.org/10.7732/kjpr.2015.28.1.135

Uses and Values of Perilla (Perilla frutescens var. frutescens) as a Functional Oil Source  

Choi, Yong-Soon (Department of Medical Biotechnology, Kangwon National University)
Publication Information
Korean Journal of Plant Resources / v.28, no.1, 2015 , pp. 135-144 More about this Journal
Abstract
The Korean daily intake of vegetable oils has increased about 2.5-fold from 17 g/day to 46 g/day for the last several decades. Perilla (Perilla frutescens var. frutescens) has been cultivated in Korea for a long time as a dietary oil seed which has the highest content of ${\alpha}$-linolenic acid, accounting for nearly 60%. It is known that the main role of ALA is as a precursor to the longer-chain ${\omega}-3$, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), the metabolic products of ${\alpha}$-linolenic acid (ALA, ${\omega}-3$). Dietary ${\omega}-3$ fatty acids reduce inflammation and the risk of chronic diseases such as heart disease, cancer, and arthritis, but they also may act as functional components for cognitive and behavioral function. Thus, ${\alpha}$-linolenic acid is one of the essential nutrients in modern dietary patterns in which much linoleic acid is consumed. Nevertheless, perilla oil, rich in ${\alpha}$-linolenic acid, can be easily oxidized, giving rise to controversies with respect to shelf life, the deterioration of the product's commercial value, and further related toxicity. Recent research using genetic modifications has tried to develop new plant oil seeds that balance the ratio of ${\omega}-6/{\omega}-3$ fatty acids. Such trials could be a strategy for improving an easily oxidizable property of perilla oil due to high ${\alpha}$-linolenic acid. Alternatively, appropriate application of antioxidant to the oil can be considerable.
Keywords
${\alpha}$-Linolenic acid; Linoleic acid; Oxidative stability; Genetic modification; ${\omega}-6/{\omega}-3$;
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1 Wang, S., H. Hwang, S. Yoon and E. Choe. 2010. Temperature dependence of autoxidation of perilla oil and tocopherol degradation. J. Food Chem. 75:C498-505.   DOI   ScienceOn
2 Wilson, B.J., J.E. Garst, R.D. Linnabary, R.B. Channell. 1977. Perilla ketone: a potent lung toxin from the mint plant, Perilla frutescens Britton. Science 197:573-574.   DOI
3 Yeo, K.M. and H.S. Choi. 1998. Nutritional characteristics and industrial application of perilla oil. Food Ind. Nutr. 3:30-36.
4 Yin, Z.J., H.L. Liu, X. Dong, L. Tian, L. Xiao, Y.N. Xu and L.Q. Qu. 2014. Increasing $\alpha$-linolenic acid content in rice bran by embryo-specific expression of ${\omega}3/{\Delta}15$-desaturase gene. Mol. Breeding 33:987-996.   DOI
5 Yun, J.M. and J. Surh. 2012. Fatty acid composition as a predictor for the oxidation stability of Korean vegetable oils with or without induced oxidative stress. Prev. Nutr. Food Sci. 17:158-165.   DOI
6 서미정, 정정환, 고미정. 2009. 들깨유래 마이크로좀 리놀레산 불포화효소 유전자로 형질전환된 형질전환 식물체 및 이 유전자를 이용하여 형질전환식물체의 종자 오일에서 지방산 조성을 조절하는 방법(Korea Patent No. 10-2009-0028284).
7 Adhikari, P., K.T. Hwang, J.N. Park and C.K. Kim. 2006. Policosanol content and composition in perilla seeds. J. Agric Food Chem. 54:5359-5362.   DOI
8 Arterburn, L.M., E.B. Hall and H. Oken. 2006. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J. Clin. Nutr. 83(supple):1467s-1476s.
9 Asaf, A.K. 2006. Effect of fatty acids and tocopherols on the oxidative stability of vegetable oils. Eur. J. Lipid Sci. Technol. 58:1051-1061.
10 Asif, M. 2012. Phytochemical study of polyphenols in Perilla Frutescens as an antioxidant. Avicenna J. Phytomed. 2:169-178.
11 Barcelo-Coblijn, G. and E.J. Murphy. 2009. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Prog. Lipid Res. 48:355-374.   DOI
12 Bae, N.K., I.S. Kwon and Y.C. Cho. 2009. Ten year change of body mass index in Korean: 1997-2007. Korean J. Obesity. 18:24-30.
13 Brenna, J.T., N. Salem Jr., A.J. Sinclair and S.C. Cunnane. 2009. $\alpha$-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prost. Leuko. Essen. Fatty Acids. 80:85-91.   DOI
14 Burdge, G. 2006. Metabolism of $\alpha$-linolenic acid in humans. Prostaglandins Leukot Essent Fatty acids. 75:161-168.   DOI
15 Cahoon, E.B., S.E. Hall, K.G. Ripp, T.S. Ganzke, W.D. Hitz and S.J. Coughlan. 2003. Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content. Nature Biotechnol. 21:1082-1087.   DOI
16 Damude, H.G. and A.J. Kinney. 2008. Engineering oil seeds to produce nutritional fatty acids. Physiol. Plant. 132:1-10.
17 Choi, C.U. 1998. History and science of sesame oil and perilla oil. J. Kor. Soc. Food Cook Sci. 14:443-452.
18 Chung, C.H., Kim, J.L., Lee, Y.C. and Y.L. Choi. 1999. Cloning and characterization of a seed-specific ${\omega}-3$ fatty acid desaturase cDNA from Perilla frutescens. Plant Cell Physiol. 40:114-118.   DOI
19 Chung, H.B. 2012. 'Globalization of omega-3 perilla oil' as a new green growth plant. Spring Symposium of The Plant Resources Society of Korea (Abstract book). p. 5.
20 DeLany, J.P., M.M. Windhauser, C.M. Champagne and G.A. Bray. 2000. Differential oxidation of individual dietary fatty acids in humans. Am. J. Clin. Nutr. 72:905-911.
21 Esterbauer, H. 1993. Cytotoxicty and genotoxicty of lipid-oxidation products. Am. J. Clin. Nutr. 57(suppl):779s-786s.
22 Ezaki, O., M. Takahashi, T. Shigematsu, K. Shimamura, J. Kimura, H. Ezaki and T. Gotoh. 1999. Long-term effects of dietary alpha-linolenic acid from perilla oil on serum fatty acids composition and on the risk factors of coronary heart disease in Japanese elderly subjects. J. Nutr. Sci. Vitaminol. 45:759-772.   DOI
23 Frankel, E.N. 2006. Recent advances in lipid oxidation. J. Sci. Food Agric. 54:495-511.
24 Ghebremeskel, K., Y. Min, M.A. Crawford, J.H. Nam, A. Kim, J.N. Koo and H. Suzuki. 2000. Blood fatty acid composition of pregnant and nonpregnant Korean women: Red cells may act as a reservoir of arachidonic acid and docosahexaenoic acid for utilization by the developing fetus. Lipids 35:567-574.   DOI
25 Harris, W.S. 2010. The omega-3 index: clinical utility for therapeutic intervention. Curr. Cardiol. Rep. 12:503-508.   DOI
26 Gordon, M.H. 2004. Factors affecting lipid oxidation: In Steele, R. (ed.), Understanding and Measuring the Shelf-Life of Food, CRC Press. Cambridge, England. pp. 128-141.
27 Gurr, M.I., J.L. Harwood and K.N. Frayn 2002. Lipid Biochemistry. 5th. Blackwell Science, Oxford, UK.
28 Harris, W.S., S.L. Lemke, S.N. Hansen, D.A. Goldstein, M.A. DiRienzo, H. Su, M.A. Nemeth, M.L. Taylor, G. Ahmed and C. George. 2008. Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker. Lipids 43:805-811.   DOI
29 Hibbeln, J.R., L.RG. Nieminen, T.L. Blasbalg, J.A. Riggs and W.EM Lands. 2006. Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am. J. Clin. Nutr. 83(suppl):1483s-1493s.
30 Holman, R.T. and O.C. Elmer. 1947. The rates of oxidation of unsaturated fatty acids and esters. J. Am. Oil Chem. Soc. 24:127-129.   DOI
31 Horrocks, L,A. and Y.K. Yeo. 1999. Health benefits of DHA. Pharmacol. Res. 40:211-225.   DOI
32 Huang, S.W., E.N. Frankel and J.B. German. 1994. Antioxidant activity of $\alpha$ - and $\gamma$-tocopherols in bulk oils and in oil-in-water emulsions. J. Agric. Food Chem. 42:2108-2114.   DOI
33 Hwang, Y.S., K.H. Kim, S.K. Hwang, S.H. Lee, S.K. Lee, J.B. Kim, S.B. Choi, T. Okita and D. Kim. 1999. Molecular modificaqtion of Perilla lipid composition. J. Plant Biotechnol.1:20-30.
34 Jung, J.H., H. Kim, Y.S. Go, S.B. Lee, C.G. Hur, H.U. Kim and M.C. Suh 2011. Identification of functional BrFAD2-1 gene encoding microsomal delta-12 fatty acid desaturase from Brassica rapa and development of Brassica napus containing high oleic acid contents. Plant Cell Rep. 30:1881-1892.   DOI
35 Ichihara, K. and Y. Suda. 2003. Lipid biosynthesis in developing perilla seeds. Phytochemistry 63:139-143.   DOI
36 Innis, S.M. 2007. Dietary (n-3) fatty acids and brain development. J. Nutr. 137:855-859.
37 Jang, J.H. 1995. Historic Report on Traditional Fats and Oils originated from Korea (한국 전래 유지류사 연구). Soohaksa,Seoul, Korea. (in Korean).
38 Jung, D.M., S.H. Yoon and M.Y. Jung 2012. Chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods. J. Food Sci. 77:C1249-C1255.   DOI   ScienceOn
39 Kashima, M., G.S. Cha, Y. Isoda, J. Hirano, and T. Miyazawa. 1991. The antioxidant effects of phospholipids on perilla oil. J. Am. Oil Chem. Soc. 68:119-122.   DOI
40 KHIDI (Korea health industry development institute) 2013. 2012 Production of food and food additives(Vol.1). Statistical Yearbook. Seoul, Korea.
41 Kim, Y.E., I.H. Kim and Y.C Lee. 1996. Characteristics of browning materials in perilla oil and change of oxidative stability of blended perilla oil. Kor. J. Food Nutr. 9:504-508.
42 Kim, G.H., S.K. Kim, M.W. Park and H.P. Moon. 1999a. Breeding strategies to increase production potential of major food crops in Korea. Plant Breeding Biotech. 31:80-101.
43 Kim, M.J., Y.S. Go, S.J. Ahn, C.H. Chung and M.C. Suh. 2008. Functional complementation of a perilla ${\omega}-3$ fatty acid desaturase under the seed-specific SeFAD2 promotor. J. Plant Biol. 51:174-179.   DOI
44 Kim, C.K., H.W. Oh and Y.J. Kwon. 1999b. Effect of the mixing extraction of perilla seed and peanut on physicochemical characteristics and oxidative stability of perilla oil. J. Korean Soc. Food Sci. Nutr. 28:1212-1219.
45 Kim, S., S. Moon and B.M. Popkin. 2000a. The nutrition transition in South Korea. Am. J. Clin. Nutr. 71:44-53.
46 Kim, J.S., Y.J. Kim, Y.O. Ahn, H.Y. Paik and K. Tajima. 2004. Contribution of specific foods to fat, fatty acids, and cholesterol in the development of a food frequency questionnaire in Koreans. Asia Pac. J. Clin. Nutr. 13:265-272.
47 Knothe, G. 2002. Structure indices in FA chemistry. How relevant is the iodine value? J. Am. Oil Chem. Soc. 79:847-854.   DOI   ScienceOn
48 Kolanowski, W., D. Jaworska, J. Weissbrodt and B. Kunz. 2006. Sensory assessment of microencapsulated fish oil powder. J. Am. Chem. Soc. 84:37-45.
49 Korean Nutrition Society. 2010. Dietary reference intakes for Koreans. First revision. Korean Nutrition Society, Seoul,Korea.
50 KREI (Korea Rural Economic Institute). 2012. 2011 Food Balance Sheet, Seoul, Korea.
51 Kyung, K.H. 2008. Issues about GMO and global supply of food grains. Food Sci. Ind. 41:16-26.
52 Lee, S.Y. and Y.S. Choi. 1990. Cholesterol. ShinKwang Publishing, Seoul, Korea. (in Korean).
53 Lee, B.K., S.L. Kim, K.H. Kim, S.H. Yu, S.C. Lee, Z. Zhang, M.S. Kim, H.M. Park and J.Y. Lee. 2008. Seed specific expression of perilla $\gamma$-tocopherol methyltransferase gene increases $\alpha$-tocopherol content in transgenic perilla (Perilla frutescens). Plant Cell Tiss. Organ Cult. 92:47-54.
54 Lee, J.I., J.K. Bang, B.H. Lee and K.H. Kim. 1991. Quality improvement in perilla. Korean J. Breed. Sci. 3:48-61.
55 Lee, Y.J. and K.W. Oh. 2001. Transition of dietary fat in Korean and it's issues. Korean J. Lipidol. 11:39-48.
56 Lee, J.K., M. Nitta, N.S. Kim, C.H. Park, K.M. Yoon, Y.B. Shin and O. Ohnishi. 2002. Genetic diversity of perilla and related weedy types in Korea determined by AFLP analyses. Crop Sci. 42:2161-2166.   DOI
57 Lee, M.H., T.J. Ha, C.S. Jung, S.B. Pae, J.D. Hwang, S.I. Han, C.H. Park, K.Y. Park, S.K. Lee and C.B. Park. 2010. A new perilla cultivar for edible seed 'Anyu' with early maturity and high oil content. Korean J. Breed. Sci. 42:218-221.
58 Lee, T.S., Y.H. Lee, K.S. Kim, W. Kim, K.S. Kim, Y.S. Jang and K.G. Park. 2012. Characteristics of fatty acid composition and properties by blending of vegetable oils. Korean J. Plant Res. 25:624-632.   DOI   ScienceOn
59 Lee, J.H., K.H. Park, M.H. Lee, H.T. Kim, W.D. Seo, J.Y. Kim, I.Y. Baek, D.S. Jang and T.J. Ha. 2013. Identification, characterization, and quantification of phenolic compounds in the antioxidant activity-containing fraction from the seeds of Korean perilla (Perilla frutescens) cultivars. Food Chem. 136:842-852.
60 Lim, J., S. Kim, S. Ke and B. Cho. 2011. The prevalence of obesity, abdominal obesity and metabolic syndrome among elderly in general population. Korean J. Farm. Med. 32:128-134   DOI
61 Nogi, A., J. Yang, L. Li, M. Yamasaki, M. Watanabe, M. Hashimoto and K. Shiwaku. 2007. Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian Workers. J. Occup. Health 49:205-216.   DOI
62 Lorgeril, M. and P. Salen. 2004. Alpha-linolenic acid and coronary heart disease. Nutr. Metab. Cardiovasc Dis. 14:162-169.   DOI
63 Mattson, F.H. and E.S. Lutton. 1958. The specific distribution of fatty acids in the glycerides of animal and vegetable fats. J. Biol. Chem. 233:868-871.
64 Nice, G.B. Johnson and B. Shelton. Beefsteak Plant (Perilla Mint), Purdue University. https://www.extension.purdue.edu/extmedia/BP/ WS-43-W.pdf. Accessed 27. July, 2014.
65 Oh, K.W., C.M. Nam, J.H. Park, J.Y. Young, J.S. Shim, K.H. Lee and I. Suh. 2003. A case control study on dietary quality and risk for coronary heart disease in Korean men. Korean Nutr. Soc. 36:613-621.
66 Ohlrogge, J.B. 1994. Design of New Plant Products: Engineering of fatty acid metabolism. Plant Physiol. Mar 104:821-826.   DOI
67 Park, Y.S. 2010. Omega-3 index as a risk factor for cardiovascular disease and its application to Koreans population. Korean J. Obesity. 19:1-8.
68 Patterson, E., R. Wall, G.F. Fitzgerald, R.P. Ross and C. Stanton. 2012. Health implications of high dietary omega-6 polyun-saturated fatty acids, J. Nutr. Metab. article ID 539426.
69 Rahman, H., S.D. Singer and R.J. Weselake. 2013. Development of low-linolenic acid Brassica oleracea lines through seed mutagenesis and molecular characterization of mutants. Tech. Appl. Genet. 126:1587-1598.   DOI
70 Raskin, I., D.M. Ribnicky, S. Komarnytsky, N. Ilic, A. Poulev,N. Borisjuk, A. Brinker, D.A. Moreno, C. Ripoll, N. Yakoby,J.M. O' Neal, T. Cornwell, I. Pastor and B. Fridlender. 2002.Plants and human health in the twenty-first century. TRENDS Biotechnol. 20:522-531.   DOI
71 RDA (Rural Development Administration). http://www.rda.go.kr/board/board.do?mode=html&prgId=arg_newvarietyQuery&srccode=IC&fccode2=1602#wap. Accessed 10 July,2014.
72 Sajo Corporation. Ranking 'first' for 43 years 'Haepyo edible oil'. http://ind.sajo.co.kr/promotion Center/storyView.asp, Accessed 15 July, 2014.
73 Schmitz, G. and J. Ecker. 2008. The opposing effects of n-3 and n-6 fatty acids. Prog. Lipid Res. 47:147-155.   DOI
74 Seo, W.H. and H.H. Baek. 2009. Characteristic aroma-active compounds of Korean perilla (Perilla frutescens Britt) leaf. J. Agric Food Chem. 57:11537-11542.   DOI
75 Shin, H.S. and S.W. Kim. 1994. Lipid composition of perilla seed. J. Am. Oil Chem. Soc. 71:619-622.   DOI
76 Simopoulos, A.P. 2002. Omega-3 fatty acids in wild plants, nuts and seeds. Asia Pacific J. Clin. Nutr. 11(Supple):163s-173s.   DOI
77 Sinclair. A. J., N.M. Attar-Bashi and D. Li. 2002. What is the role of α-linolenic acid for mammals?. Lipids 37:1113-1123.   DOI
78 Singh, S.P., X.R. Zhou, Q. Liu, S. Stymne and A.G. Green. 2005. Metabolic engineering of new fatty acids in plants. Curr. Opin. Plant Biol. 8:197-203.   DOI
79 Spector, A.A. 1999. Essentialty of fatty acids. Lipids 34:s1-s3.   DOI
80 Sprecher, H. D.L. Luthria, B.S. Mohammed and S.P. Baykousheva. 1995. Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J. Lipid Res. 36:2471-2477.
81 Sugano, M. and J.H. Lee. 1989. Nutritional and physiological significance of lipids. J. Dispersion Sci. Technol. 10:643-665.   DOI
82 Swanson, D., R. Block, S.A. Mousa. 2012. Omega-3 fatty acids EPA and DHA: health benefits throughout life. Adv. Nutr. 3:1-7.   DOI
83 Tan, C.P., Y.B.C. Man, J. Selamat and M.S.A. Yusoff. 2002. Comparative studies of oxidative stability of edible oils by differential scanning calorimetry and oxidative stability index methods. Food Chem. 76:385-389.   DOI
84 Tapiero, H., G.N. Ba, P. Couvreur and K.D. Tew. 2002. Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomed. Pharmacother. 56:215-222.   DOI
85 Tsuchiya, A., J. Hardy, T. M. Burbacher, E. M. Faustman, and K. Marien. 2008. Fish intake guidelines: incorporating n-3 fatty acid intake and contaminant exposure in the Korean and Japanese communities. Am. J. Clin. Nutr. 87:1867-1875.
86 Uauy, R. and A.D. Dangour. 2006 Nutirion in brain development and aging: role of essential fatty acids. Nutr Rev. 64:S24-S33.   DOI
87 Ursin, V.M. 2003. Modification of plant lipids for human health: Development of functional land-based omega-3 fatty acids. J. Nutr. 133:4271-4274.
88 Vrinten, P., Z. Hu, M.A. Munchinsky, G. Rowland and X. Qiu. 2005. Two FAD3 desaturase genes control the level of linolenic acid in flax seed. Plant Physiol. 139:79-87.   DOI