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http://dx.doi.org/10.7732/kjpr.2015.28.1.001

Effect of Dioscorea Rhizoma on Gastritis by Acute Gastric Ulcer in Rats  

Park, Young Mi (Department of Biological Science, Andong National University)
Lim, Jae Hwan (Department of Biological Science, Andong National University)
Seo, Eul Won (Department of Biological Science, Andong National University)
Publication Information
Korean Journal of Plant Resources / v.28, no.1, 2015 , pp. 1-8 More about this Journal
Abstract
In order to verify the effects of Dioscorea Rhizoma on gastrointestinal damages, we investigated the protective role of the crude extracts on induced gastric ulceration in rats. Rats administered of Dioscorea Rhizoma extracts showed gradually decreased congestion and hemorrhage, but control group did not show any symptom in gastric tissue. Moreover, Dioscorea Rhizoma extract had a role in lowering gastrin and histamine levels in gastric ulcer rats, thereby inhibiting the gastric tissue damages. Excessive production of malondialdehyde shown in gastric ulcer rats was declined in all rats administered with Dioscorea Rhizoma extract as well as the levels of SOD and GPX surged by acute gastric ulcer. Also, the increased activity of CAT showed an effect in activation of antioxidant enzyme to normal state. All data suggest that Dioscorea Rhizoma extract was verified to be highly effective resource in improving the gastrointestinal function of rats by preventing from gastric tissue damage in acute gastric ulcer and restoring the activities of plasma substances and antioxidant enzymes.
Keywords
Gastric mucosa; Malondialdehyde; Gastrin; Histamine; Antioxidant enzymes;
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