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http://dx.doi.org/10.7732/kjpr.2014.27.6.601

Screening of Plants with Inhibitory Activity on Cellular Senescence  

Lee, Seung-Eun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Kim, Jae-Ryong (Department of Biochemistry and Molecular Biology, Yeungnam University)
Noh, Hyung-Jun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Kim, Geum-Sook (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Lee, Jeong-Hoon (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Choi, Jehun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Lee, Dae-Young (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Kim, Seung-Yu (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Publication Information
Korean Journal of Plant Resources / v.27, no.6, 2014 , pp. 601-609 More about this Journal
Abstract
In this study, the effect of plant extract on the senescence action and cell survival rate in two types of cells, in which aging was derived by adriamycin, was analyzed to find the materials for suppressing cell senescence from natural resources. The results are as follows. For human umbilical vein endothelial cells (HUVECs), the fruit of Physalis angulata L. and the aerial part of Synurus deltoides (Aiton) Nakai showed excellent cell-senescence inhibition activities in a treatment concentration-dependent manner, demonstrating the high possibility for utilization as a material for prevention and treatment for vascular diseases. The water extract from the root of Polygonatum odoratum var. pluriflorum for variegatum Y. N. Lee showed potent cell-senescence inhibitory effect for human dermal fibroblasts (HDFs). Thus it is considered that the additional study on the plant needs for elucidating the possible utilization as material for skin health improvement.
Keywords
Cellular senescence; HDF; HUVEC; SA-${\beta}$-gal;
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Times Cited By KSCI : 4  (Citation Analysis)
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