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http://dx.doi.org/10.7732/kjpr.2014.27.3.209

Anti-Inflammatory Effect of the Extracts from Abeliophyllum distichum Nakai in LPS-Stimulated RAW264.7 Cells  

Park, Gwang Hun (Department of Bioresource Sciences, Andong National University)
Park, Jae Ho (Department of Medicinal Plant Science, Jungwon University)
Eo, Hyun Ji (Department of Bioresource Sciences, Andong National University)
Song, Hun Min (Department of Bioresource Sciences, Andong National University)
Lee, Man Hyo (Gyeongbuk Institute for Bio-industry)
Lee, Jeong Rak (Gyeongbuk Institute for Bio-industry)
Jeong, Jin Boo (Department of Bioresource Sciences, Andong National University)
Publication Information
Korean Journal of Plant Resources / v.27, no.3, 2014 , pp. 209-214 More about this Journal
Abstract
In this study, we investigated whether A. distichum decreases the production of inflammatory mediators through downregulation of the NF-${\kappa}B$ and ERK pathway. Our data indicated that A. distichum leaf inhibits the overexpression of iNOS in protein and mRNA levels, and subsequently blocked LPS-mediated NO overproduction in RAW264.7 cells. A. distichum leaf inhibited $I{\kappa}B-{\alpha}$ degradation and p65 nuclear translocation, and subsequently suppressed transcriptional activity of NF-${\kappa}B$ in LPS-stimulated RAW264.7 cells. In addition, A. distichum leaf suppressed LPS-induced ERK1/2 activation by decreasing phosphorylation of ERK1/2. These findings suggest that A. distichum leaf shows anti-inflammatory activities through suppressing ERK-mediated NF-${\kappa}B$ activation in mouse macrophage.
Keywords
Abeliophyllum distichum Nakai; Anti-inflammation; ERK1/2; NF-${\kappa}B$;
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