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http://dx.doi.org/10.7732/kjpr.2014.27.1.011

Acute Oral Toxicity of Atractylodes macrocepala KOIDZ.  

Choi, Hye-Kyung (Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Roh, Hang-Sik (Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Jeong, Ja-Young (Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety)
Ha, Hun-Yong (Department of National Medicine Resources, Semyung University)
Publication Information
Korean Journal of Plant Resources / v.27, no.1, 2014 , pp. 11-21 More about this Journal
Abstract
Atractylodes macrocepala KOIDZ. (AmK) is a herbal medicine and resources of functional food which has been used for the treatment of indigestion, anorexia, diarrhea and digestive dysfunction. Recently AmK is frequently used as resources of functional food and whitening cosmetics. In this study was carried out to evaluate the acute oral toxicity of Amk in Sprague-Dawley(SD) rats. male and female rats were administered orally with Amk extract of 1,000 mg/kg (low dosage group), 2,000 mg/kg (middle dosage group) and 4,000 mg/kg (high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. But we found out feeble histopathological changes in liver fat tissues. In addition no significant changes of gross bady and individual organs weight. These results suggest that water soluble extract of AmK has not acute oral toxicity and oral $LD_{50}$ value was over 4,000 mg/kg in SD rats.
Keywords
Acute; Atractylodes macrocepala KOIDZ.; Herbal medicine; $LD_{50}$; SD rat; Toxicity;
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