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http://dx.doi.org/10.7732/kjpr.2013.26.4.441

Screening of Useful Plants with Anti-inflammatory and Antioxidant Activity  

Lee, Seung-Eun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Choi, Jehun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Lee, Jeong-Hoon (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Noh, Hyung-Jun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Kim, Geum-Sook (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Kim, Jinkyung (Department of Biochemical Science, Catholic University of Daegu)
Chung, Hae-Young (Department of Pharmacy, Pusan National University)
Kim, Seung-Yu (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science)
Publication Information
Korean Journal of Plant Resources / v.26, no.4, 2013 , pp. 441-449 More about this Journal
Abstract
This study was conducted to select some useful plants as functional material candidates. A total of 38 plants were preliminarily screened for the anti-inflammatory and antioxidant activities. The preliminarily selected 8 plants were further investigated to verify the in vitro inhibitory effect on inflammation and oxidative stress. Boehmeria platanifolia (root), Carpinus coreana (branch), and Eupatorium japonicum (leaf) inhibited the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Eupatorium japonicum (leaf) suppressed the expression of cyclooxygenase-2 (COX-2), whereas Boehmeria platanifolia (root) and Prunus yedoensis (branch) inhibited the transcription of nuclear factor-kappa B (NF-${\kappa}B$). Treatment with the extracts ($2.5{\sim}20{\mu}g/ml$) of Abutilon theophrasti (leaf, flower/seed) and Hemistepta lyrata (stem) did not show toxicity on RAW 264.7 cell proliferation, but treatment with $2.5{\mu}g/ml$ of Boehmeria platanifolia (root) exhibited cell toxicity. Carpinus coreana (branch) and Prunus yedoensis (branch) showed potent scavenging activities on peroxynitrite. Akebia quinata (flower), Carpinus coreana (branch), and Prunus yedoensis (branch) effectively inhibited reactive oxygen species (ROS). Abutilon theophrasti (leaf), Boehmeria platanifolia (root), Carpinus coreana (branch), and Eupatorium japonicum (leaf) exhibited strong inhibitory capacity with regard to nitric oxide (NO) production. The results suggested that Abutilon theophrasti (leaf) has in vitro anti-inflammatory and antioxidant activities, and that is a useful functional material candidate.
Keywords
Abutilon theophrasti; Antioxidation; Anti-Inflammation; NF-${\kappa}B$; COX-2;
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