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http://dx.doi.org/10.7732/kjpr.2012.25.5.507

Protective Effect of Quercus salicina Blume Extract in Calcium Oxalate Urolithiasis Model  

Heo, Jin-Sun (IK Science Co., Ltd.)
Kim, Jong-Bok (IK Science Co., Ltd.)
You, Han-Choon (Forest Resources Research Institude of Jeollanam-Do)
Lee, Min-Su (College of Pharmacy, Kyungsung University)
Choi, Jong-Won (College of Pharmacy, Kyungsung University)
Publication Information
Korean Journal of Plant Resources / v.25, no.5, 2012 , pp. 507-516 More about this Journal
Abstract
Kidney stones occur in approximately 1% of the population during their lifetime. Although the development of extracorporeal shock wave lithotripsy (SWL) has revolutionized the theraphy of urolithiasis, the rate of recurrence of urothiasis, the rate of recurrenece of stones after SWL is about 50% within 10 years, which still represents serious problems for patienes. So to clarify the mechanism of Urocalum, and QS (Quercus salicina Blume) extract in the treatment of urolithiasis. Rat calcium oxalate urolithiasis was induced by oral administration of ethylene glycol and the vitamin D3 analog alfacalcidol for 14 days and QS extract was given to rats. After the last administration, we measured in urine, serum and renal oxidative stress marker. Ethylene glycol and alfacalcidol treatment increased BUN, creatinine, uric acid and XO. This increase was significantly suppressed by the administration of QS extract. These finding suggest that the QS extract plays a role in the prevention of stone formation and recureence in urolithiasis.
Keywords
Alfacalcidol; BUN; Urolithiasis; Kidney stones; Quercus salicina Blume;
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