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The Analgesic Effect and Mechanisms of Dianthus chinensis L Extract in the mice.  

Park, Soo-Hyun (Department of Pharmacology, College of Medicine, Hallym University)
Sim, Yun-Beom (Department of Pharmacology, College of Medicine, Hallym University)
Lee, Jin-Koo (Department of Pharmacology, College of Medicine, Hallym University)
Lim, Soon-Sung (Institute of Natural Medicine, College of Medicine, Hallym University)
Kim, Jin-Kyu (Institute of Natural Medicine, College of Medicine, Hallym University)
Suh, Hong-Won (Department of Pharmacology, College of Medicine, Hallym University)
Publication Information
Korean Journal of Plant Resources / v.23, no.6, 2010 , pp. 513-518 More about this Journal
Abstract
In the present study, the antinociceptive profiles of Dianthus chinensis L extract were examined in ICR mice. Dianthus chinensis L extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Dianthus chinensis L extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7\;{\mu}g$) was diminished by Dianthus chinensis L extract. Intraperitoneal (i.p.) pretreatment with yohimbine ($\alpha_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Dianthus chinensis L extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Dianthus chinensis L extract in the writhing test. Our results suggest that Dianthus chinensis L extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Dianthus chinensis L extract may be mediated by $\alpha_2$-adrenergic receptor, but not opioidergic and serotonergic receptors.
Keywords
Dianthus chinensis L; Anti-nociception; Inflammatory pain; $\alpha_2$ adrenoceptor;
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1 Jensen TS, Yaksh TL. 1984. Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites. Brain Research 321: 287-297.   DOI   ScienceOn
2 Wigdor S, Wilcox GL. 1987. Central and systemic morphineinduced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways. Journal of pharmacology and Experimental Therapeutics 242: 90-95.
3 Yaksh TL. 1979. Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinpciceptive effects of morphine in the periaqueductal gray. Brain Resesrch 160: 180-185.   DOI   ScienceOn
4 Park SH, Sim YB, Choi SM, Seo YJ, Kwon MS, Lee JK, Suh HW. 2009. Antinociceptive Profiles and Mechanisms of Orally Administered Vanillin in the Mice. Arch Pharm Res. 32(11): 1643-1649.   과학기술학회마을   DOI
5 Schmauss C, Yaksh TL. 1984. In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat. Journal of Pharmacology and Experimental Therapeutics 228: 1-12.
6 Suh HW, Song DK, Son KH, Wie MB, Lee KH, Jung KY, Do JC, Kim YH. 1996. Antinociceptive mechanisms of dipsacus saponin C administered intracerebroventricularly in the mouse. General Pharmacology 27: 1167-1172.   DOI   ScienceOn
7 Suh HW, Song DK, Kim YH. 1997. Differntial effects of adenosine receptor antagonist injected intrathecally on antinociception induced by morphine and beta-endorphin administered intracerebroventricularly in the mouse. Neuropeptides 31: 339-344.   DOI   ScienceOn
8 Hylden JL, Wilcox GL. 1981. Intrathecal substance P elicits a caudally- directed biting and scratching behavior in mice. Brain Reserch 217: 212-215.   DOI   ScienceOn
9 Koster R, Anderson M, Beer EJ. 1959. Acetic acid for analgesic screening. Federal Proceeding 18: 412.
10 Eddy NB, Leimbach D. 1953. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. Journal of Pharmacology and Experimental Therapeutics 107: 385-93.
11 Flora of Chinna. 1753. Dianthus chinensis Linnaeus, Flora of Chinna. vol. 6, 104
12 Grumbach L. 1966. The prediction of analgesic activity in man by animal testing. In: Knighton RS, Dumke PR, editors. Pain. Boston: Little Brown and Co.; 163-82.
13 Huxley A. 1992. New RHS Dictionary of Gardening. Macmillan, ISBN 0-333-47494-5.
14 Hylden JL, Wilcox GL. 1980. Intrathecal morphine in mice: a new technique. European Journal of Pharmacology 67: 313-316.   DOI   ScienceOn
15 Suh HW, Chung KM, Kim YH, Huh SO, Song DK. 1999. Effect of histamine receptor antagonists injected intrathecally on antinociception induced by opioids administered intracerebroventricularly in the mouse. Neuropeptides 33: 121-129.   DOI
16 D'Amour FE, Smith DL. 1941. A method for determining loss of pain sensation. Journal of Pharmacology and Experimental Therapeutics 72: 74-9.
17 Chapman CR, Casey KL, Dubner R, Foley KM, Gracely RH, Reading AE. 1985. Pain measurement: an overview. Pain 22: 1-31.
18 Choi SS, Han KJ, Lee JK, Lee HK, Han EJ, Kim DH, Suh HW. 2003. Antinociceptive mechanisms of orally administered decursinol in the mouse. Life sciences 13(73): 471-485.
19 Cumberbatch MJ, Herrero JH, Headley PM. 1994. Exposure of rat spinal neurons to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli. Neuroscience Letters 181: 98-102.   DOI   ScienceOn
20 Yaksh TL. 1984. Multiple opioid receptor systems in brain and spinal cord: Part I. European Journal of Anaesthesiology 1: 171-199.