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Anti-diabetic Effects of Mixed Extracts from Lycium chinense, Cordyceps militaris, and Acanthopanax senticosus  

Kim, Dae-Jung (Department of Bio-Health Technology, Kangwon National University)
Kim, Jeong-Mi (Department of Bio-Health Technology, Kangwon National University)
Kim, Tae-Hyuck (Department of Bio-Health Technology, Kangwon National University)
Baek, Jong-Mi (Department of Bio-Health Technology, Kangwon National University)
Kim, Hyun-Sook (Well-being Bioproducts RIC Center, Kangwon National University)
Choe, Myeon (Department of Bio-Health Technology, Kangwon National University)
Publication Information
Korean Journal of Plant Resources / v.23, no.5, 2010 , pp. 423-429 More about this Journal
Abstract
In this study, we examined the anti-diabetic activity in vitro by the mixed Korean herb water extracts(JDG) composed of Lycium chinense, Cordyceps militaris, and Acanthopanax senticosus on hepatic glucose-regulating enzyme activities such as glucokinase(GK), acetyl-CoA carboxylase(ACC), and inhibition activity of $\alpha$-glucosidase. The hepatic cytosol fraction of a type II diabetic animal(Goto-Kakizaki rat) was used in GK and ACC activity assays. JDG mixed water extracts significantly increased the hepatic GK and ACC activity. The highest anti-$\alpha$-glucosidase activity was observed in JDG 5 water extract when compared to the acarbose control, inhibitor of $\alpha$-glucosidase. We suggest that Lycium chinense, Cordyceps militaris, and Acanthopanax senticosus mixed water extracts may exert an anti-diabetic activity by enhancing the glucose metabolism and may be used as natural $\alpha$-glucosidase inhibitors in type 2 diabetic conditions.
Keywords
diabetic; glucokinase; acetyl CoA carboxylase; $\alpha$-glucosidase;
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Times Cited By KSCI : 11  (Citation Analysis)
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