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Antioxidant Activities and Whitening Effect of the Mulberry (Morus alba L.) Root Bark Extracts  

Jee, Sun-Ok (Department of Cosmetic Science, Joongbu University)
Publication Information
Korean Journal of Plant Resources / v.22, no.2, 2009 , pp. 145-151 More about this Journal
Abstract
This study was performed to investigate the antioxidant activities and the whitening effect of mulberry (Morus alba L.) root bark extracts. The antioxidant activities of water and 70% ethanol extracts of mulberry root bark were 65.8% and 87.0% in the DPPH assay at $1,000\;{\mu}g/ml$ ; 89.3% and 77.1% in the ABTS assay at $1,000\;{\mu}g/ml$. Xanthine oxidase inhibition of water and 70% ethanol extracts were 100% and 96.2% at $1,000\;{\mu}g/ml$. Nitric oxide radical inhibition of water and 70% ethanol extracts showed 43.5% and 53.0% at $500\;{\mu}g/ml$, and it was similar to the BHA effect(43.8%). Tyrosinase inhibitory activities of water and 70% ethanol extracts were 79.6% and 93.5% at $1,000\;{\mu}g/ml$. These results confirm that mulberry root bark has the great potential to be a cosmeceutical ingredient with a natural antioxidant and a skin-whitening effect.
Keywords
Morus alba L. DPPH; ABTS; Nitric oxide; Xanthine oxidase; Tyrosinase;
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1 Cho, Y.J., I.S. Ju, O.J. Kwon, S.S. Chun, B.J. An and J.H. Kim. 2008. Biological and antimicrobial activity of Portulaca oleracea. J. Korean Soc. Appl. biol. Chem. 51:49-54   과학기술학회마을   PUBMED
2 Choe, S.Y. and K.H. Yang. 1982. Toxicological studies of antioxidants, butylated hydroxytoluene(BHT) and butylated hydroxyanisole(BHA). Korean J. Hood Sci. Technol. 12:283-288
3 Choi, C.H., E.S. Song, J.S. Kim and M.H. Kang. 2003. Antioxidative activities of Castanea crenata Flos. methanol extracts. Korean J. Food Sci. Technol. 35:1216-1220   과학기술학회마을
4 Duke, E.J., P. Joyce and J.P. Ryan. 1973. Characterization of alternative molecular forms of xanthine oxidase in the mouse. Eur. J. Biochem. 187:131-140
5 Hatano, T., T. Tasuhara, T. Fukuda, T. Noro and T. Okuda. 1989. Phenolic constituents of licoricell. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase. Chemical & Pamaceutical Bulletin 37:3005-3009   DOI   ScienceOn
6 Kang Y.H., Y.K. Park, S.R. Oh and K.D. Moon. 1995. Studies on the physiological functionality of ine needle and mugwort extracts. Korean J. Food Sci. Technol. 27:978-984   과학기술학회마을
7 Kim, Y.Y., R.W. Choue, S.Y. Chung and S.J. Koo. 1999. Anti-hyperglycemic effect of Cortex Mori radics in db/db mice. Korean J. Food Sci. Technol. 31:1057-1064   과학기술학회마을
8 Li, H.C., S. Yashiki, J. Sonda, H. Lou, S.K. Gosh, J.J. Byrnes and C. Lema, T. Fujiyoshi, M. Karasuyama and S. Sonoda. 2000. Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients. Jpn. J. Cancer Res. 91:34-40   DOI   PUBMED   ScienceOn
9 Park, U.Y., S.H. Kim, J.H. Kim, Y.G. Kim, and D.S. Chang. 1995. Purification of antimicrobial substance for the extract from the root bark of Morus alba. J. Fd Hyg-Safety 10:225-230   과학기술학회마을
10 Peter, T.P. 1998. The skin's antioxidant systems. Dermatol. Nurs. 10:401-406
11 Re, R., N. Pellegrin, R. A. Proteggente, A. Pannala, M. Yang and R.E. Catherine. 1999. Antioxidant activities applying an approved ABTS radical caution decolorization assay. Free radical Biology & Medicine 26:1231-1237   PUBMED
12 Stirpe, F. and E.D. Corte. 1969. The regulation of rat liver xanthine oxidase. J Biochem. 244:3855-3861
13 Swan, G.A. 1974. Structure, chemistry, and biosynthesis of the melanins. Fortschritte Chemie. Organischer Naturstoffe 31:521-582
14 Yoon, C.Y. , D.H. Shin, C.M. Hong, W.K. Lee, D.D. Jang, J.C. Cho and J.K. Ahn. 1998. The suppressive effects of Cortex mori on No, TNF-$\alpha$ and IL-1 production by macrophage. Kor. J. Vet. Publ. Hlth. 22:281-292
15 Ziegler, D. W., H.D. Hutchison and R.E. Kissing. 1971. Induction of xanthine oxidase by virus infections in newborn mice. Infect. and Immun. 3:237   PUBMED
16 Wyngaarden, J.B. and E.W. Jr. Holmes. 1977. Molecular nature of enzyme regulation in purine biosynthesis. Ciba Foundation Symposium 48:43-64   PUBMED
17 Yang, J.H., D.K. Kim, M.Y. Yun and J.K. An. 2006. Antioxidative activity and therapeutic effect of the hydrogel preparations of Scutellariae Radix and Zingiberis Rhizoma on dermatitis. J. Kor. Pharm. Sci. 36:253-262   DOI   ScienceOn
18 Cho, Y.J., S.S. Chun, H.J. Kwon, J.H. Kim, K.H. Lee, B.J. An and J.W. Choo. 2006. Inhibitory effects of water and 80% Ethanol extracts from Mulberry leaves(Morus alba L.) on angiotensin converting enzyme and xanthine oxidase. J. Korean Soc. Appl. Biol. Chem. 49:114-124   과학기술학회마을   PUBMED
19 Lee, H.S., S.J. Yun, Y.K. Moon and J.Y. Moon. 2000. Hair growth effects of Mori Cortex Radicis mixture on the hair of rat. Korean J. Seric. Sci. 42:83-86   과학기술학회마을
20 Ikeda, T. and T. Tsutsumi. 1990. Function and skin depimental activity of crude drugs. Fragrance Journal 6:59-62
21 Park, I.K. , J.O. Lee, H.S. Lee, K.Y. Seol and Y.J. Ahn. 1998. Cytotoxic activity of Bombyx mori and Morus alba derived materials against human tumor cell lines. J. Korean Soc. Appl. Biol. Chem. 41:187-190   과학기술학회마을
22 Korner, A. and J. Pawelek. 1982. Mammalian tyrosinase catalyzes three reaction in the biosynthesis of melanin. Science 217:1163-1165   DOI   PUBMED
23 Min, H.Y., E.J. Park, S.K. Lee and Y.J. Cho. 2003. Effects of grape extraction free radical scaverging activity and inhibition of pro-inflammatory mediator production in mouse macrophage cells. Korean J. food Sci. Technol. 35:132-137   과학기술학회마을
24 Marcocci, L., J.J. Maguire, M.T. Droylefaix and L. Packer. 1994. The nitric oxide scavenging properties of Ginkgo biloba extract EGb 761. Biochem Biophys Res Commun. 201:748-755   DOI   ScienceOn
25 Kim, A.K., H. Ha and S.H. Yoon. 1995. Liver protective effects of Mori Radicis Cortex in isolated hepatocytes. J. Korea Soc. Hygienic Sciences 1:16-20
26 Liang, Y.C., Y.T. Huang, S.H. Tsai, S.Y. Lin-shiau, C.F. Chen and J.K. Lin. 1999. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and relted flavonoids in mouse macrophase. Carcinogenesis 20:1945-1952   DOI   ScienceOn
27 Lerner, A.B. and T.B. Fitzpatrick. 1950. Biochemistry of melanin formation. Physiological reviews 30:91-126   DOI   PUBMED
28 Hikino, H., Y. Mizuno, T. Oshima and C. Konno. 1985. Isolation and hypoglycemic activity of Moran A, a glycoprotein of Morus alba root barks. Plant Medica. 51:159-163   DOI   ScienceOn
29 Reiter, R.J. 1995. Oxidative process and antioxidative defense mechanism in the aging brain. FASEB J. 9:526-533   DOI
30 Ding, A.H., C.F. Nathan and D.J. Stuhr. 1988. Release of reactive nitrogen intermediates and active oxygen intermediates from mouse peritoneal macrophages. J. Imuno. 141:2407-2412
31 Jung, S.H., W.A. Jo, J.H. Son, E.Y. Choi, C.I. Park, I.C. Lee, B.J. An, A.R. Son, S.K. Kim, Y.S. Kim and J.T. Lee. 2005. A study on the application of cosmetic materials and the physiological activities of Forsythia koreana Nakai. Kor. J. Herbology 20:61-68   과학기술학회마을
32 Yoon, S.H., S.Y. Jung and H. Ha. 2001. Hypoglycemic and enzyme effects of the water extract of Mori Rodicis Cortex in streptozotocin-induced diabetic rats. J. Korean Soc. Hygienic Sciences 7:119-123
33 Halliwell, B., J.M.C. Gutteridge and C.E. Cross. 1992. Free radicals, antioxidants and human disease. J. Lab. Clin. Med. 119:598-620
34 Jung, S.H., W.A. Jo, J.H. Son, E.Y. Choi, C.I. Park, I.C. Lee, B.J. An, A.R. Son, S.K. Kim, Y.S. Kim and J.T. Lee. 2005. A study on the application of cosmetic materials and the physiological activities of Forsythia koreana Nakai. Kor. J. Herbology 20:61-68   과학기술학회마을
35 Blois, M. S. 1958. Antioxidant determination by the use of a stable free radical. Nature 181:1199-1200   DOI   ScienceOn
36 Park, J.C., J.S. Choi and J.W. Choi. 1995. Effects of the fractions from the leaves, fruits, stems and roots of Cudrania tricuspidata and flavonoids on lipid peroxidation. Kor. J. Pharmacogn. 26:377-384   과학기술학회마을
37 Jang, M.J., B.J. An, C.E. Lee, J.T. Lee, B.G. Lee and D.H. Lee. 2008. Study on the anti-oxidant effect of Pinus rigida Mill. inner bark extract. Jour. Korean For. Soc. 97:88-94
38 Jin, Y.Z., S.Y. Ahn, S.S. Hong, G.H. Li, E.K. Kim and K.H. Row. 2005. Extraction of whitening agents from natural plants and whitening effect. Korean Ind. Eng. Chem. 16:348-353
39 Kim, H.K., Y.E. Kim, J.R. Do, Y.C. Lee and B.Y. Lee. 1995. Antioxidative activity and physiological activity of some Korean medical plants. Korean J. Food Sci. Technol. 27:80-85   과학기술학회마을
40 Yoo J.Y. S.H. Park, I.A. Hwang, S.J. Jo, C.H. Huh, S.W. Youn and K.C. Park. 2003. A clinical study on the effect of a cream cotaining Ramulus Mori extract and tea tree oil on Acne Vulgaris and aerobic skin flora. Korean J. Dermatol. 41:1136-1141
41 Kim, S.M., Y.S. Cho and S.K. Sung. 2001. The antioxidant ability and nitrite scavenging ability of plant extracts. Korean J. Food Sci. Technol. 33:626-632   과학기술학회마을