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Studies on the Effect of Corilagin Isolated from Euphorbia helioscopia on Collagen-Induced Arthritis (I);Analysis of Fluorescence Flow Cytometry from Collagen II Induced Arthritis Mice Model  

Shin, Sam-Kee (Dept. of Oriental Medicine Resources, Joongbu University)
Jang, Jun-Pok (Dept. of Oriental Medicine Resources, Joongbu University)
Doh, Eun-Soo (Dept. of Oriental Medicine Resources, Joongbu University)
Publication Information
Korean Journal of Plant Resources / v.21, no.4, 2008 , pp. 329-335 More about this Journal
Abstract
This study was intended to research into the possibility of corilagin (CRN) isolated from Euphorbia helioscopia as rheumatoid arthritis drug. For the study, CRN was medicated to the abdominal cavity of collagen induced arthritis (CIA) mice that was a animal model for rheumatoid arthritis and its effects on incidence and arthritis index (AI) were studied. The results were as folllows; Medicating corilagin that were isolated from Euphorbia heliscopia to CIA mice resulted in inhibiting an incidence of arthritis and reducing in arthritis index. It was found that inflammatory cells were remarkably decreased and joint cavity was well secured. Also it was displayed that the formation of pannus was not observed and a cartilage was preserved well by cell histological research. Performing fluorescence flow cytometry of CIA mice resulted in reducing in inflammatory cells infiltrated each tissue.
Keywords
Corilagin; Collagen induce arthritis mice; Arthritis; Fluorescence flow cytometry; Inflammatory cells;
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Times Cited By KSCI : 3  (Citation Analysis)
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