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The Antioxidant and Anticancer Effects of Butterbur (Petasites japonicus) Extracts  

Seo, Hun-Seok (Department of Crop Science, College of Agriculture, Chungbuk National University)
Jeong, Bong-Hwan (Bio Organic Material & Food Center, Seowon University)
Cho, Yong-Gu (Department of Crop Science, College of Agriculture, Chungbuk National University)
Publication Information
Korean Journal of Plant Resources / v.21, no.4, 2008 , pp. 265-269 More about this Journal
Abstract
The antioxidant activities of the extracts of butterbur (Petasites japonicus) derived from different extraction methods were investigated. SOD (superoxide dismutase)-like activity differed according to the extraction solvents, showing a greater antioxidant effect with ethanol solvent than that of water. Ethanol extracts of butterbur leaves showed higher SOD-like activity of 96.7% than those of water extracts. The contents of polyphenolic compounds were higher in water extracts than those in ethanol extracts. The highest content of polyphenolic compounds was 223mg/g dry weight for butterbur leaves. EDA of butterbur roots was 61.5% in the water extract and EDA in butterbur leaves was 34.9% in the ethanol extract. The anticancer effects with the extracts of butterbur were experimented by fractionations with different solvents. 41.9% of the growth of stomach cancer cells, SNU-719, were inhibited and also 72.7% of the growth of liver cancer cells, Hep3B, were inhibited by the butanol fractions of butterbur, while not affecting the growth of normal cell, DC 2.4.
Keywords
SOD-like activity; EDA (electron donating ability); Polyphenol; Anticancer; Stomach cancer; Liver cancer;
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Times Cited By KSCI : 5  (Citation Analysis)
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