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Therapeutic Effect of the Mixed Extract of Panax ginseng C.A. Mey. and Chaenomeles sinensis Koehne on the Injury of Brain Tissue in the Mice by Alzheimer's Disease  

Han, Sin-Hee (Dept. of Oriental Health Care, Joongbu University)
Doh, Eun-Soo (Dept. of Oriental Medicine Resources, Joongbu University)
Publication Information
Korean Journal of Plant Resources / v.20, no.4, 2007 , pp. 325-330 More about this Journal
Abstract
This study was conducted to investigate the effect of the mixed extract of P. ginseng C.A. Mey. and C. sinensis K. (Gin-CHF) on the infarction area of hippocampus in the mice with Alzheimer's disease induced by ${\beta}-amyloid({\beta}A)$. The Gin-CHF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. The Gin-CHF extract reduced the Tau protein, GFAP protein, and presenilin1/presenilin2 protein (immunohistochemistry) of hippocampus in the mice with Alzheimer's disease induced by ${\beta}A$. These results suggest that the Gin-CHF extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Gin-CHF extract for Alzheimer's disease is suggested for further research.
Keywords
Panax ginseng; Chaenomeles sinensis; Alzheimer's disease;
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1 Foster N.L., R.C. Petersen, S.I. Gracon and K. Lewis. 1996. An enriched-population, double-blind, placebo-controlled, crossover study of tacrine and lecithin in Alzheimer's disease. Dementia 7(5): 260-266
2 민성길. 1999. 최신 정신의학. 일조각. 서울. pp. 186-187
3 변용찬. 1997. 치매노인의 현황과 정책과제. 보건복지포럼 제13 호. pp. 35-42
4 이광우, 정희원. 1997. 임상신경학. 고려의학. 서울. pp. 199-210
5 강병수 외. 2000. 본초학. 영림사. 서울. pp. 272-273
6 김이화 외. 1997. 치태치료의 最近硏究動向에 關한 考察. 大韓鍼 灸學會誌14(2): 124
7 이가옥. 1994. 노인생활실태 분석 및 정책과제. 한국보건사회연구원. pp. 114-132
8 김보경 외. 1997. Alzheimer형 치태환자 2例에 對한 臨床的 考察. 동의신경정신과학회지 8(2): 97-106
9 Borchelt D.R., G. Thinakaren, C.B. Eckman, M.K. Lee, F. Davenport, T. Ratovitsky, C-.M. Prada, G. Kim, S. Seekins, D. Yager, H.H. Slunt, R. Wang, S.G. Younkin and S.S. Sisodia. 1996. Familial Alzheimer's diease-linked presenilin 1 variants elevate ${\beta}$A1-42/1-40 ratio in vitro and in vivo. Neuron 17: 1005-1013   DOI   ScienceOn
10 金知赫, 黃義完. 1992. 東醫精神醫學. 現代醫學書籍社. 서울. pp. 256-330
11 McGeer E.G. and P.L. McGeer. 1989. The importance of inflammatory mechanisms in Alzheimer disease. Exp. Gerontol. 33(5): 371-378   DOI   ScienceOn
12 김창민 외. 1999. 중약대사전. 정담출판사. 서울. pp. 4490-4497
13 Breakfield X.O. and N.A. DeLuca. 1991. Herpes simplex virus for gene delivery to neurons. New Biol. 3: 203-218
14 Baddeley A.D., S. Bressi, S.D. Sala, R. Logie and H. Soinnler. 1991. The decline of working memory in Alzheimer's disease. Brain 114: 2521-2542   DOI   ScienceOn
15 Lemere C.A., F. Lopera, K.S. Kosik, C.L. Lendon, J. Ossa, T.C. Saido, H. Yamaguchi, A. Ruiz, A. Maritnez, L. Madrigal, L. Hincapie, J.C. Arango, D.C. Anthony, E.H. Koo, A.M. Goate, D.J. Selkoe and J.C. Arango. 1996. The E280A presenilin 1 Alzheimer mutation produces increased ${\beta}$A 42 deposition and severe cerebellar pathology. Nat Med. 2(10): 1146-1150   DOI   ScienceOn
16 Whitehouse P.J., D.L. Price, R.G. Struble, A.W. Clark, J.T. Coyle and M.R. Delon. 1982. Alzheimer's disease and senile dementia ; loss of neurons in the basal forebrain. Science. 215(4537): 1237-1239   DOI
17 Selkoe D.J. 1991. Scientific American. November : 68-72