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http://dx.doi.org/10.4490/algae.2021.36.4.28

Liposoluble portion of the red alga Pyropia yezoensis protects alcohol induced liver injury in mice  

Lee, Ji-Hyeok (Natural Products Research Division, Honam National Institute of Biological Resources)
Ahn, Ginne (Department of Marine Bio-Food Sciences, Chonnam National University)
Ko, Ju-Young (Department of Marine Life science, Jeju National University)
Kang, Nalae (Department of Marine Bio-Food Sciences, Chonnam National University)
Jung, Kyungsook (Immunoregulatory Materials Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Han, Eui-Jeong (Department of Marine Bio-Food Sciences, Chonnam National University)
Kim, Gwang-Hoon (Department of Biology, College of Natural Sciences, Kongju National University)
Kim, Hee Jeong (Jeju Institute of Korean Medicine)
Choi, Cheol Soo (Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University)
Jeon, You-Jin (Department of Marine Life science, Jeju National University)
Publication Information
ALGAE / v.36, no.3, 2021 , pp. 219-229 More about this Journal
Abstract
The hepatoprotective effect of liposoluble portion of Pyropia yezoensis (PYLP) was investigated against alcohol-induced liver injury in mice. Fatty acids were predominant in PYLP obtained from hexane fraction of 70% EtOH extract after ultrasonication. In particular, polyunsaturated fatty acids such as eicosapentaenoic acid and linoleic acid accounted for 56.91% of the total lipids. PYLP significantly reduced liver damage induced by the alcohol treatment in mice. PYLP treatment increased the activity of antioxidant enzymes including superoxide dismutase, catalase, and glutathion peroxidase by reducing thiobarbituric acid reactive substances. Histological observations showed that PYLP minimizes damage to living tissue induced by alcohol treatment by modulating the expression level of proteins involved in the anti-apoptotic signaling pathway. Our results suggest that PYLP, rich in polyunsaturated fatty acids extracted from the red alga P. yezoensis, will be useful as a potential liver protectant in the hangover industry.
Keywords
alcohol damage; hepatic protective effect; liposoluble portion; marine red alga; polyunsaturated fatty acids; Pyropia yezoensis;
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