1 |
Hagen, C., Braune, W. & Bjorn, L. O. 1994. Functional aspects of secondary carotenoids in Haematococcus lacustris (Volvocales). III. Action as a sunshade. J. Phycol. 30:241-248.
DOI
ScienceOn
|
2 |
Hagen, C., Braune, W. & Greulich, F. 1993. Functional-aspects of secondary carotenoids in Haematococcus lacustris [Girod] Rostafinski (Volvocales). IV. Protection from photodynamic damage. J. Photochem. Photobiol. B 20:153-160.
DOI
ScienceOn
|
3 |
Hagen, C., Grunewald, K., Schmidt, S., & Muller, J. 2000. Accumulation of secondary carotenoids in flagellates of Haematococcus pluvialis (Chlorophyta) is accompanied by an increase in per unit chlorophyll productivity of photosynthesis. Eur. J. Phycol. 35:75-82.
DOI
ScienceOn
|
4 |
Hagen, C., Siegmund, S. & Braune, W. 2008. Ultrastructural and chemical changes in the cell wall of Haematococcus pluvialis (Vovocales, Chlorophyta) during aplanospore formation. Eur. J. Phycol. 37:217-226.
|
5 |
Han, D., Wang, J., Sommerfeld, M. & Hu, Q. 2012. Susceptibility and potective mechanisms of motile and nonmotile cells of Haematococcus pluvialis (Chlorophyceae) to photooxidative stress. J. Phycol. 48:693-705.
DOI
ScienceOn
|
6 |
Harker, M., Tsavalos, A. J. & Young, A. J. 1996a. Autotrophic growth and carotenoid production of Haematococcus Chlorophycepluvialis in a 30 liter air-lift photobioreactor. J. Ferment. Bioeng. 82:113-118.
DOI
ScienceOn
|
7 |
Harker, M., Tsavalos, A. J. & Young, A. J. 1996b. Factors responsible for astaxanthin formation in the chlorophyte Haematococcus pluvialis. Bioresour. Technol. 55:207-214.
DOI
ScienceOn
|
8 |
Hasunuma, T., Miyazawa, S. I., Yoshimura, S., Shinzaki, Y., Tomizawa, K. I., Shindo, K., Choi, S. K., Misawa, N. & Miyake, C. 2008. Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering. Plant J. 55:857-868.
DOI
ScienceOn
|
9 |
Hata, N., Ogbonna, J. C., Hasegawa, Y., Taroda, H. & Tanaka, H. 2001. Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic-photoautotrophic culture. J. Appl. Phycol. 13:395-402.
DOI
ScienceOn
|
10 |
Hershkovits, G., Dubinsky, Z. & Katcoff, D. J. 1997. A novel homologue of the prokaryotic htrA gene is differentially expressed in the alga Haematococcus pluvialis following stress. Mol. Gen. Genet. 254:345-350.
DOI
|
11 |
Hoffman, Y., Aflalo, C., Zarka, A., Gutman, J., James, T. Y. & Boussiba, S. 2008. Isolation and characterization of a novel chytrid species (phylum Blastocladiomycota), parasitic on the green alga Haermatococcus. Mycol. Res. 112:70-81.
DOI
ScienceOn
|
12 |
Holtin, K., Kuehnle, M., Rehbein, J., Schuler, P., Nicholson, G. & Albert, K. 2009. Determination of astaxanthin and astaxanthin esters in the microalgae Haematococcus pluvialis by LC-(APCI)MS and characterization of predominant carotenoid isomers by NMR spectroscopy. Anal. Bioanal. Chem. 395:1613-1622.
DOI
ScienceOn
|
13 |
Disch, A., Schwender, J., Muller, C., Lichtenthaler, H. K. & Rohmer, M. 1998. Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714. Biochem. J. 333:381-388.
DOI
|
14 |
Droop, M. R. 1954. Conditions governing haematochrome formation and loss in the alga Haematococcus pluvialis Flotow. Arch. Microbiol. 20:391-397.
|
15 |
Elliot, A. M. 1934. Morphology and life history of Haematococcus pluvialis. Arch. Protistenk 82:250-272.
|
16 |
Eom, H., Lee, C. G. & Jin, E. 2006. Gene expression profile analysis in astaxanthin-induced Haematococcus pluvialis using a cDNA microarray. Planta 223:1231-1242.
DOI
ScienceOn
|
17 |
Fabregas, J., Otero, A., Maseda, A. & Dominguez, A. 2001. Two-stage cultures for the production of astaxanthin from Haematococcus pluvialis. J. Biotechnol. 89:65-71.
DOI
ScienceOn
|
18 |
Fey, V., Wagner, R., Brautigam, K. & Pfannschmidt, T. 2005. Photosynthetic redox control of nuclear gene expression. J. Exp. Bot. 56:1491-1498.
DOI
ScienceOn
|
19 |
Fan, L., Vonshak, A. & Boussiba, S. 1994. Effect of temperature and irradiance on growth of Haematococcus pluvialis (Chlorophyceae). J. Phycol. 30:829-833.
DOI
ScienceOn
|
20 |
Fan, L., Vonshak, A., Zarka, A. & Boussiba, S. 1998. Does astaxanthin protect Haematococcus against light damage? Z. Naturforsch. C 53:93-100.
|
21 |
Fraser, P. D., Shimada, H. & Misawa, N. 1998. Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay. Eur. J. Biochem. 252:229-236.
DOI
ScienceOn
|
22 |
Garcia-Malea, M. C., Acien, F. G., Del Rio, E., Fernandez, J. M., Ceron, M. C., Guerrero, M. G. & Molina-Grima, E. 2009. Production of astaxanthin by Haematococcus pluvialis: taking the one-step system outdoors. Biotechnol. Bioeng. 102:651-657.
DOI
ScienceOn
|
23 |
Green, J. 1963. Occurrence of astaxanthin in euglenoid Trachelomonas volvocina. Comp. Biochem. Physiol. 9:313-316.
DOI
ScienceOn
|
24 |
Grunewald, K., Eckert, M., Hirschberg, J. & Hagen, C. 2000. Phytoene desaturase is localized exclusively in the chloroplast and up-regulated at the mRNA level during accumulation of secondary carotenoids in Haematococcus pluvialis (Volvocales, Chlorophyceae). Plant Physiol. 122:1261-1268.
DOI
|
25 |
Grunewald, K., Hirschberg, J. & Hagen, C. 2001. Ketocarotenoid biosynthesis outside of plastids in the unicellular green alga Haematococcus pluvialis. J. Biol. Chem. 276:6023-6029.
DOI
ScienceOn
|
26 |
Grung, M., Metzger, P. & Liaaen-Jensen, S. 1994. Algal carotenoids 53: secondary carotenoids of algae 4. Secondary carotenoids in the green alga Botryococcus braunii, race L, new strain. Biochem. Syst. Ecol. 22:25-29.
DOI
ScienceOn
|
27 |
Choi, Y. -E., Yun, Y. -S., Park, J. M. & Yang, J. -W. 2011. Determination of the time transferring cells for astaxanthin production considering two-stage process of Haematococcus pluvialis cultivation. Bioresour. Technol. 102:11249-11253.
DOI
ScienceOn
|
28 |
Guerin, M., Huntley, M. E. & Olaizola, M. 2003. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol. 21:210-216.
DOI
ScienceOn
|
29 |
Gutman, J., Zarka, A. & Boussiba, S. 2009. The host-range of Paraphysoderma sedebokerensis, a chytrid that infects Haematococcus pluvialis. Eur. J. Phycol. 44:509-514.
DOI
ScienceOn
|
30 |
Choi, Y. E., Yun, Y. -S. & Park, J. M. 2002. Evaluation of factors promoting astaxanthin production by a unicellular green alga, Haematococcus pluvialis, with fractional factorial design. Biotechnol. Prog. 18:1170-1175.
DOI
ScienceOn
|
31 |
Cifuentes, A. S., Gonzalez, M. A., Vargas, S., Hoeneisen, M. & Gonzalez, N. 2003. Optimization of biomass, total carotenoids and astaxanthin production in Haematococcus pluvialis Flotow strain Steptoe (Nevada, USA) under laboratory conditions. Biol. Res. 36:343-357.
|
32 |
Cordero, B. F., Couso, I., Leon, R., Rodriguez, H. & Vargas, M. A. 2011. Enhancement of carotenoids biosynthesis in Chlamydomonas reinhardtii by nuclear transformation using a phytoene synthase gene isolated from Chlorella zofingiensis. Appl. Microbiol. Biotechnol. 91:341-351.
DOI
|
33 |
Cordero, B. F., Couso, I., Leon, R., Rodriguez, H. & Vargas, M. A. 2012. Isolation and characterization of a lycopene epsilon-cyclase gene of Chlorella (Chromochloris) zofingiensis: regulation of the carotenogenic pathway by nitrogen and light. Mar. Drugs 10:2069-2088.
DOI
|
34 |
Cordero, B. F., Obraztsova, I., Martin, L., Couso, I., Leon, R., Vargas, M. A. & Rodriguez, H. 2010. Isolation and characterization of a lycopene -cyclase gene from the astaxanthin-producing green alga Chlorella zofingiensis (Chlorophyta). J. Phycol. 46:1229-1238.
DOI
ScienceOn
|
35 |
Del Campo, J. A., Rodriguez, H., Moreno, J., Vargas, M. A., Rilight vas, J. & Guerrero, M. G. 2004. Accumulation of astaxanthin and lutein in Chlorella zofingiensis (Chlorophyta). Appl. Microbiol. Biotechnol. 64:848-854.
DOI
|
36 |
Cunningham, F. X. & Gantt, E. 1998. Genes and enzymes of carotenoid biosynthesis in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49:557-583.
DOI
ScienceOn
|
37 |
Cunningham, F. X., Pogson, B., Sun, Z., McDonald, K. A., DellaPenna, D. & Gantt, E. 1996. Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell 8:1613-1626.
|
38 |
Damiani, M. C., Leonardi, P. I., Pieroni, O. I. & Caceres, E. J. 2006. Ultrastructure of the cyst wall of Haematococcus pluvialis (Chlorophyceae): wall development and behaviour during cyst germination. Phycologia 45:616-623.
DOI
|
39 |
Del Rio, E., Acien, F. G., Garcia-Malea, M. C., Rivas, J., Molina-Grima, E. & Guerrero, M. G. 2005. Efficient one-step production of astaxanthin by the microalga Haematococcus pluvialis in continuous culture. Biotechnol. Bioeng. 91:808-815.
DOI
ScienceOn
|
40 |
Del Rio, E., Acien, F. G., Garcia-Malea, M. C., Rivas, J., Molina-Grima, E. & Guerrero, M. G. 2008. Efficiency assessment of the one-step production of astaxanthin by the microalga Haematococcus pluvialis. Biotechnol. Bioeng. 100:397-402.
DOI
ScienceOn
|
41 |
Bar, E., Rise, M., Vishkautsan, M. & Arad, S. 1995. Pigment and structural changes in Chlorella zofingiensis upon and nitrogen stress. J. Plant Physiol. 146:527-534.
DOI
ScienceOn
|
42 |
Barbosa, M. J., Morais, R. & Choubert, G. 1999. Effect of carotenoid source and dietary lipid content on blood astaxanthin concentration in rainbow trout (Oncorhynchus mykiss). Aquaculture 176:331-341.
DOI
ScienceOn
|
43 |
Zhong, Y. -J., Huang, J. -C., Liu, J., Li, Y., Jiang, Y., Xu, Z. -F., Sandmann, G. & Chen, F. 2011. Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis. J. Exp. Bot. 62:3659-3669.
DOI
ScienceOn
|
44 |
Yuan, J. -P., Gong, X. -D. & Chen, F. 1997. Separation and analysis of carotenoids and chlorophylls in Haematococcus lacustris by high-performance liquid chromatography photodiode array detection. J. Agric. Food Chem. 45:1952-1956.
DOI
ScienceOn
|
45 |
Zhang, X. W., Gong, X. -D. & Chen, F. 1999. Kinetic models for astaxanthin production by high cell density mixotrophic culture of the microalga Haematococcus pluvialis. J. Ind. Microbiol. Biotechnol. 23:691-696.
DOI
ScienceOn
|
46 |
Zhekisheva, M., Boussiba, S., Khozin-Goldberg, I., Zarka, A. & Cohen, Z. 2002. Accumulation of oleic acid in Haematococcus pluvialis (Chlorophyceae) under nitrogen starvation or high light is correlated with that of astaxanthin esters. J. Phycol. 38:325-331.
DOI
ScienceOn
|
47 |
Zlotnik, I., Sukenik, A. & Dubinsky, Z. 1993. Physiological and photosynthetic changes during the formation of red aplanospores in the Chlorophyte Haematococcus pluvialis. J. Phycol. 29:463-469.
DOI
ScienceOn
|
48 |
Triki, A., Maillard, P. & Gudin, C. 1997. Gametogenesis in Haematococcus pluvialis Flotow (Volvocales, Chlorophyta). Phycologia 36:190-194.
DOI
|
49 |
Ugwu, C. U., Aoyagi, H. & Uchiyama, H. 2008. Photobioreactors for mass cultivation of algae. Bioresour. Technol. 99:4021-4028.
DOI
ScienceOn
|
50 |
Bidigare, R. R., Ondrusek, M. E., Kennicutt, M. C., Iturriaga, R., Harvey, H. R., Hoham, R. W. & Macko, S. A. 1993. Evidence for a photoprotective function for secondary carotenoids of snow algae. J. Phycol. 29:427-434.
DOI
ScienceOn
|
51 |
Boussiba, S. 2000. Carotenogenesis in the green alga Haematococcus pluvialis: cellular physiology and stress response. Physiol Plant. 108:111-117.
DOI
ScienceOn
|
52 |
Boussiba, S., Bing, W., Yuan, J. -P., Zarka, A. & Chen, F. 1999. Changes in pigments profile in the green alga Haeamtococcus pluvialis exposed to environmental stresses. Biotechnol. Lett. 21:601-604.
DOI
ScienceOn
|
53 |
Boussiba, S., Fan, L. & Vonshak, A. 1992. Enhancement and determination of astaxanthin accumulation in green alga Haematococcus pluvialis. Methods Enzymol. 213:386-391.
DOI
|
54 |
Boussiba, S. & Vonshak, A. 1991. Astaxanthin accumulation in the green alga Haematococcus pluvialis. Plant Cell Physiol. 32:1077-1082.
|
55 |
Brinda, B. R., Sarada, R., Kamath, B. S., & Ravishankar, G. A. 2004. Accumulation of astaxanthin in flagellated cells of Haematococcus pluvialis - cultural and regulatory aspects. Curr. Sci. (Bangalore) 87:1290-1294.
|
56 |
Bubrick, P. 1991. Production of astaxanthin from Haematococcus. Bioresour. Technol. 38:237-239.
DOI
ScienceOn
|
57 |
Carol, P., Stevenson, D., Bisanz, C., Breitenbach, J., Sandmann, G., Mache, R., Coupland, G. & Kuntz, M. 1999. Mutations in the Arabidopsis gene immutans cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation. Plant Cell 11:57-68.
DOI
|
58 |
Carvalho, A. P., Meireles, L. A. & Malcata, F. X. 2006. Microalgal reactors: a review of enclosed system designs and performances. Biotechnol. Prog. 22:1490-1506.
DOI
|
59 |
Vechtel, B., Kahmann, U. & Ruppel, H. G. 1992. Secondary carotenoids of Eremosphaera viridis De Bary (Chlorophyceae) under nitrogen deficiency. Bot. Acta 105:219-222.
DOI
|
60 |
Vanlerberghe, G. C. & McIntosh, L. 1996. Signals regulating the expression of the nuclear gene encoding alternative oxidase of plant mitochondria. Plant Physiol. 111:589-595.
DOI
|
61 |
Vershinin, A. 1999. Biological functions of carotenoids: diversity and evolution. Biofactors 10:99-104.
DOI
|
62 |
Vidhyavathi, R., Venkatachalam, L., Sarada, R. & Ravishankar, G. A. 2008. Regulation of carotenoid biosynthetic genes expression and carotenoid accumulation in the green alga Haematococcus pluvialis under nutrient stress conditions. J. Exp. Bot. 59:1409-1418.
DOI
ScienceOn
|
63 |
Wang, B., Zarka, A., Trebst, A. & Boussiba, S. 2003. Astaxanthin accumulation in Haematococcus pluvialis (Chlorophyceae) as an active photoprotective process under high irradiance. J. Phycol. 39:1116-1124.
DOI
ScienceOn
|
64 |
Wang, C. W., Oh, M. K. & Liao, J. C. 1999. Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli. Biotechnol. Bioeng. 62:235-241.
DOI
ScienceOn
|
65 |
Wang, J., Han, D., Sommerfeld, M. R., Lu, C. & Hu, Q. 2013. Effect of initial biomass density on growth and astaxanthin production of Haematococcus pluvialis in an outdoor photobioreactor. J. Appl. Phycol. 25:253-260.
DOI
|
66 |
Wang, J., Sommerfeld, M. & Hu, Q. 2009. Occurrence and environmental stress responses of two plastid terminal oxidases in Haematococcus pluvialis (Chlorophyceae). Planta 230:191-203.
DOI
|
67 |
Wang, J., Sommerfeld, M. & Hu, Q. 2011. Cloning and expression of isoenzymes of superoxide dismutase in Haematococcus pluvialis (Chlorophyceae) under oxidative stress. J. Appl. Phycol. 23:995-1003.
DOI
|
68 |
Chen, G. 2007. Lipid and fatty acid composition and their biosyntheses in relation to carotenoid accumulation in the microalgae Nitzschia laevis (Bacillariophyceae) and Haematococcus pluvialis (Chlorophyceae). Ph.D. dissertation, The University of Hong Kong, Hong Kong, 150 pp.
|
69 |
Chandok, M. R., Sopory, S. K. & Oelmuller, R. 2001. Cytoplasmic kinase and phosphatase activities can induce PsaF gene expression in the absence of functional plastids: evidence that phosphorylation/dephosphorylation events are involved in interorganellar crosstalk. Mol. Gen. Genet. 264:819-826.
DOI
|
70 |
Chen, F., Chen, H. & Gong, X. 1997. Mixotrophic and heterotrophic growth of Haematococcus lacustris and rheological behaviour of the cell suspensions. Bioresour. Technol. 62:19-24.
DOI
ScienceOn
|
71 |
Chen, Y. -B., Durnford, D. G., Koblizek, M. & Falkowski, P. G. 2004. Plastid regulation of Lhcb1 transcription in the chlorophyte alga Dunaliella tertiolecta. Plant Physiol. 136:3737-3750.
DOI
ScienceOn
|
72 |
Aflalo, C., Meshulam, Y., Zarka, A. & Boussiba, S. 2007. On the relative efficiency of two-vs. one-stage production of astaxanthin by the green alga Haematococcus pluvialis. Biotechnol. Bioeng. 98:300-305.
DOI
ScienceOn
|
73 |
Asada, K. 2006. Production and scavenging of reactive oxygen species in chloroplasts and their functions. Plant Physiol. 141:391-396.
DOI
ScienceOn
|
74 |
Wang, Y. & Chen, T. 2008. The biosynthetic pathway of carotenoids in the astaxanthin-producing green alga Chlorella zofingiensis. World J. Microbiol. Biotechnol. 24:2927-2932.
DOI
|
75 |
Wang, S. B., Chen, F., Sommerfeld, M. & Hu, Q. 2004a. Proteomic analysis of molecular response to oxidative stress by the green alga Haematococcus pluvialis (Chlorophyceae). Planta 220:17-29.
DOI
ScienceOn
|
76 |
Wang, S. B., Chen, F., Sommerfeld, M. & Hu, Q. 2005. Isolation and proteomic analysis of cell wall-deficient Haematococcus pluvialis mutants. Proteomics 5:4839-4851.
DOI
ScienceOn
|
77 |
Wang, S. B., Hu, Q., Sommerfeld, M. & Chen, F. 2004b. Cell wall proteomics of the green alga Haematococcus pluvialis (Chlorophyceae). Proteomics 4:692-708.
DOI
ScienceOn
|
78 |
Wu, D. Y., Wright, D. A., Wetzel, C., Voytas, D. F. & Rodermel, S. 1999. The immutans variegation locus of Arabidopsis defines a mitochondrial alternative oxidase homolog that functions during early chloroplast biogenesis. Plant Cell 11:43-55.
DOI
|
79 |
Sarada, R., Bhattacharya, S., Bhattacharya, S. & Ravishankar, G. A. 2002. A response surface approach for the production of natural pigment astaxanthin from green alga, Haematococcus pluvialis: effect of sodium acetate, culture age, and sodium chloride. Food Biotechnol. 16:107-120.
DOI
ScienceOn
|
80 |
Sarada, R., Vidhyavathi, R., Usha, D. & Ravishankar, G. A. 2006. An efficient method for extraction of astaxanthin from green alga Haematococcus pluvialis. J. Agric. Food Chem. 54:7585-7588.
DOI
ScienceOn
|
81 |
Schoefs, B., Rmiki, N., Rachadi, J. & Lemoine, Y. 2001. Astaxanthin accumulation in Haematococcus requires a cytochrome P450 hydroxylase and an active synthesis of fatty acids. FEBS Lett. 500:125-128.
DOI
ScienceOn
|
82 |
Sun, N., Wang, Y., Li, Y. -T., Huang, J. -C. & Chen, F. 2008. Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta). Process Biochem. 43:1288-1292.
DOI
ScienceOn
|
83 |
Steinbrenner, J. & Linden, H. 2001. Regulation of two carotenoid biosynthesis genes coding for phytoene synthase and carotenoid hydroxylase during stress-induced astaxanthin formation in the green alga Haematococcus pluvialis. Plant Physiol. 125:810-817.
DOI
ScienceOn
|
84 |
Steinbrenner, J. & Linden, H. 2003. Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control. Plant Mol. Biol. 52:343-356.
DOI
ScienceOn
|
85 |
Steinbrenner, J. & Sandmann, G. 2006. Transformation of the green alga Haematococcus pluvialis with a phytoene desaturase for accelerated astaxanthin biosynthesis. Appl. Environ. Microbiol. 72:7477-7484.
DOI
ScienceOn
|
86 |
Sun, Z., Cunningham, F. X. & Gantt, E. 1998. Differential expression of two isopentenyl pyrophosphate isomerases and enhanced carotenoid accumulation in a unicellular chlorophyte. Proc. Natl. Acad. Sci. U. S. A. 95:11482-11488.
DOI
ScienceOn
|
87 |
Takeda, H. 1991. Sugar composition of the cell-wall and the taxonomy of Chlorella (Chlorophyceae). J. Phycol. 27:224-232.
DOI
ScienceOn
|
88 |
Tan, S., Cunningham, F. X., Youmans, M., Grabowski, B., Sun, Z. & Gantt, E. 1995. Cytochrome f loss in astaxanthin-accumulating red cells of Haematococcus pluvialis (Chlorophyceae): comparison of photosynthetic activity, photosynthetic enzymes, and thylakoid membrane polypeptides in red and green cells. J. Phycol. 31:897-905.
DOI
|
89 |
Tjahjono, A. E., Hayama, Y., Kakizono, T., Terada, Y., Nishio, N. & Nagai, S. 1994. Hyper-accumulation of astaxanthin in a green alga Haematococcus pluvialis at elevated temperatures. Biotechnol. Lett. 16:133-138.
DOI
ScienceOn
|
90 |
Tran, D., Haven, J., Qiu, W. -G. & Polle, J. E. W. 2009a. An update on carotenoid biosynthesis in algae: phylogenetic evidence for the existence of two classes of phytoene synthase. Planta 229:723-729.
DOI
|
91 |
Tran, N. -P., Park, J. -K. & Lee, C. -G. 2009b. Proteomics analysis of proteins in green alga Haematococcus lacustris (Chlorophyceae) expressed under combined stress of nitrogen starvation and high irradiance. Enzyme Microb. Technol. 45:241-246.
DOI
ScienceOn
|
92 |
Ma, R. Y. -N. & Chen, F. 2001. Enhanced production of free trans-astaxanthin by oxidative stress in the cultures of the green microalga Chlorococcum sp. Process Biochem. 36:1175-1179.
DOI
ScienceOn
|
93 |
Mann, V., Harker, M., Pecker, I. & Hirschberg, J. 2000. Metabolic engineering of astaxanthin production in tobacco flowers. Nat. Biotechnol. 18:888-892.
DOI
ScienceOn
|
94 |
Mendes-Pinto, M. M., Raposo, M. F. J., Bowen, J., Young, A. J. & Morais, R. 2001. Evaluation of different cell disruption processes on encysted cells of Haematococcus pluvialis: effects on astaxanthin recovery and implications for bio-availability. J. Appl. Phycol. 13:19-24.
DOI
ScienceOn
|
95 |
Miki, W. 1991. Biological functions and activities of animal carotenoids. Pure Appl. Chem. 63:141-146.
DOI
|
96 |
Misawa, N. 2009. Pathway engineering of plants toward astaxanthin production. Plant Biotechnol. 26:93-99.
DOI
ScienceOn
|
97 |
Mittler, R. 2002. Oxidative stress, antioxidants and stress tolerance. Trends Plant Sci. 7:405-410.
DOI
ScienceOn
|
98 |
Nobre, B., Marcelo, F., Passos, R., Beirao, L., Palavra, A., Gouveia, L. & Mendes, R. 2006. Supercritical carbon dioxide extraction of astaxanthin and other carotenoids from the microalga Haematococcus pluvialis. Eur. Food Res. Technol. 223:787-790.
DOI
|
99 |
Ohlrogge, J. B. & Jaworski, J. G. 1997. Regulation of fatty acid synthesis. Annu. Rev. Plant Physiol. Plant Mol. Biol. 48:109-136.
DOI
|
100 |
Nott, A., Jung, H. S., Koussevitzky, S. & Chory, J. 2006. Plastid-to-nucleus retrograde signaling. Annu. Rev. Plant Biol. 57:739-759
DOI
ScienceOn
|
101 |
Olaizola, M. 2000. Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors. J. Appl. Phycol. 12:499-506.
DOI
ScienceOn
|
102 |
Orosa, M., Torres, E., Fidalgo, P. & Abalde, J. 2000. Production and analysis of secondary carotenoids in green algae. J. Appl. Phycol. 12:553-556.
DOI
ScienceOn
|
103 |
Qin, S., Liu, G. -X. & Hu, Z. -Y. 2008. The accumulation and metabolism of astaxanthin in Scenedesmus obliquus (Chlorophyceae). Process Biochem. 43:795-802.
DOI
ScienceOn
|
104 |
Qiu, B. S. & Li, Y. 2006. Photosynthetic acclimation and photoprotective mechanism of Haematococcus pluvialis (Chlorophyceae) during the accumulation of secondary carotenoids at elevated irradiation. Phycologia 45:117-126.
DOI
ScienceOn
|
105 |
Remias, D., Karsten, U., Lutz, C. & Leya, T. 2010. Physiological and morphological processes in the alpine snow alga Chloromonas nivalis (Chlorophyceae) during cyst formation. Protoplasma 243:73-86.
DOI
|
106 |
Remias, D., Lutz-Meindl, U. & Lutz, C. 2005. Photosynthesis, pigments and ultrastructure of the alpine snow alga Chlamydomonas nivalis. Eur. J. Phycol. 40:259-268.
DOI
ScienceOn
|
107 |
Rise, M., Cohen, E., Vishkautsan, M., Cojocaru, M., Gottlieb, H. E. & Arad, S. M. 1994. Accumulation of secondary carotenoids in Chlorella zofingiensis. J. Plant Physiol. 144:287-292.
DOI
|
108 |
Santos, M. F. & Mesquita, J. F. 1984. Ultrastructure study of Haematococcus lacustris (Girod.) Rostafinski (Volvocales) I. Some aspects of carotenogenesis. Cytologia 49:215-228.
DOI
|
109 |
Li, Y., Huang, J., Sandmann, G. & Chen, F. 2008a. Glucose sensing and the mitochondrial alternative pathway are involved in the regulation of astaxanthin biosynthesis in the dark-grown Chlorella zofingiensis (Chlorophyceae). Planta 228:735-743.
DOI
|
110 |
Li, Y. 2007. The role of carotenogenesis in the response of the green alga Haematococcus pluvialis to oxidative stress. Ph.D. dissertation, The University of Hong Kong, Hong Kong, 157 pp.
|
111 |
Li, Y., Huang, J., Sandmann, G. & Chen, F. 2009. High-light and sodium chloride stress differentially regulate the biosynthesis of astaxanthin in Chlorella zofingiensis (Chlorophyceae). J. Phycol. 45:635-641.
DOI
ScienceOn
|
112 |
Li, Y., Sommerfeld, M., Chen, F. & Hu, Q. 2008b. Consumption of oxygen by astaxanthin biosynthesis: a protective mechanism against oxidative stress in Haematococcus pluvialis (Chlorophyceae). J. Plant Physiol. 165:1783-1797.
DOI
ScienceOn
|
113 |
Li, Y., Sommerfeld, M., Chen, F. & Hu, Q. 2010. Effect of photon flux densities on regulation of carotenogenesis and cell viability of Haematococcus pluvialis (Chlorophyceae). J. Appl. Phycol. 22:253-263.
DOI
ScienceOn
|
114 |
Lichtenthaler, H. K. 1999. The 1-deoxy-D-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 50:47-65.
DOI
ScienceOn
|
115 |
Lichtenthaler, H. K., Rohmer, M. & Schwender, J. 1997. Two independent biochemical pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants. Physiol. Plant. 101:643-652.
DOI
ScienceOn
|
116 |
Linden, H. 1999. Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence, regulation and functional complementation. Biochim. Biophys. Acta 1446:203-212.
DOI
ScienceOn
|
117 |
Liu, B. -H. & Lee, Y. -K. 2000. Secondary carotenoids formation by the green alga Chlorococcum sp. J. Appl. Phycol. 12:301-307.
DOI
ScienceOn
|
118 |
Liu, J., Sun, Z., Zhong, Y. J., Huang, J., Hu, Q. & Chen, F. 2012. Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. Planta 236:1665-1676.
DOI
ScienceOn
|
119 |
Liu, J., Huang, J. & Chen, F. 2009. Metabolic engineering of Chlorella zofingiensis (Chlorophyta) for enhanced biosynthesis of astaxanthin. FEBS J. 276:S283.
|
120 |
Liu, J., Huang, J., Sun, Z., Zhong, Y., Jiang, Y. & Chen, F. 2011. Differential lipid and fatty acid profiles of photoautotrophic and heterotrophic Chlorella zofingiensis: assessment of algal oils for biodiesel production. Bioresour. Technol. 102:106-110.
DOI
ScienceOn
|
121 |
Lorenz, R. T. & Cysewski, G. R. 2000. Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends Biotechnol. 18:160-167.
DOI
ScienceOn
|
122 |
Lotan, T. & Hirschberg, J. 1995. Cloning and expression in Escherichia coli of the gene encoding -C-4-oxygenase, that converts -carotene to the ketocarotenoid canthaxanthin in Haematococcus pluvialis. FEBS Lett. 364:125-128.
DOI
ScienceOn
|
123 |
Kajiwara, S., Kakizono, T., Saito, T., Kondo, K., Ohtani, T., Nishio, N., Nagai, S. & Misawa, N. 1995. Isolation and functional identification of a novel cDNA for astaxanthin biosynthesis from Haematococcus pluvialis, and astaxanthin synthesis in Escherichia coli. Plant Mol. Biol. 29:343-352.
DOI
ScienceOn
|
124 |
Kang, C. D., Lee, J. S., Park, T. H. & Sim, S. J. 2005. Comparison of heterotrophic and photoautotrophic induction on astaxanthin production by Haematococcus pluvialis. Appl. Microbiol. Biotechnol. 68:237-241.
DOI
ScienceOn
|
125 |
Kathiresan, S., Chandrashekar, A., Ravishankar, G. A. & Sarada, R. 2009. Agrobacterium-mediated transformation in the green alga Haematococcus pluvialis (Chlorophyceae, Volvocales). J. Phycol. 45:642-649.
DOI
ScienceOn
|
126 |
Kobayashi, M., Kakizono, T., Yamaguchi, K., Nishio, N. & Nagai, S. 1992. Growth and astaxanthin formation of Haematococcus pluvialis in heterotrophic and mixotrophic conditions. J. Ferment. Bioeng. 74:17-20.
DOI
ScienceOn
|
127 |
Kim, D. -K., Hong, S. -J., Bae, J. -H., Yim, N., Jin, E. S. & Lee, C. -G. 2011. Transcriptomic analysis of Haematococcus lacustris during astaxanthin accumulation under high irradiance and nutrient starvation. Biotechnol. Bioprocess Eng. 16:698-705.
DOI
ScienceOn
|
128 |
Kobayashi, M., Kakizono, T. & Nagai, S. 1993. Enhanced carotenoid biosynthesis by oxidative stress in acetate-induced cyst cells of a green unicellular alga, Haematococcus pluvialis. Appl. Environ. Microb. 59:867-873.
|
129 |
Kobayashi, M., Kakizono, T., Nishio, N., Nagai, S., Kurimura, Y. & Tsuji, Y. 1997. Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis. Appl. Microbiol. Biotechnol. 48:351-356.
DOI
ScienceOn
|
130 |
Kobayashi, M. & Sakamoto, Y. 1999. Singlet oxygen quenching ability of astaxanthin esters from the green alga Haematococcus pluvialis. Biotechnol. Lett. 21:265-269.
DOI
ScienceOn
|
131 |
Krichnavaruk, S., Shotipruk, A., Goto, M. & Pavasant, P. 2008. Supercritical carbon dioxide extraction of astaxanthin from Haematococcus pluvialis with vegetable oils as cosolvent. Bioresour. Technol. 99:5556-5560.
DOI
ScienceOn
|
132 |
Lang, N. J. 1968. Electron microscopic studies of extraplastidic astaxanthin in Haematococcus. J. Phycol. 4:12-19.
DOI
|
133 |
Lee, Y. -K. & Ding, S. -Y. 1994. Cell cycle and accumulation of astaxanthin in Haematococcus lacustris (Chlorophyta). J. Phycol. 30:445-449.
DOI
ScienceOn
|
134 |
Lemoine, Y. & Schoefs, B. 2010. Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress. Photosynth. Res. 106:155-177.
DOI
ScienceOn
|
135 |
Hu, Q., Sommerfeld, M. & Lu, F. 2006. Extractability and bioavailability of the natural antioxidant astaxanthin from a green alga, Haematococcus pluvialis. WIPO Patent No. 2006107736.
|
136 |
Leya, T., Rahn, A., Lutz, C. & Remias, D. 2009. Response of arctic snow and permafrost algae to high light and nitrogen stress by changes in pigment composition and applied aspects for biotechnology. FEMS Microbiol. Ecol. 67:432-443.
DOI
ScienceOn
|
137 |
Li, J., Zhu, D., Niu, J., Shen, S. & Wang, G. 2011. An economic assessment of astaxanthin production by large scale cultivation of Haematococcus pluvialis. Biotechnol. Adv. 29:568-574.
DOI
ScienceOn
|
138 |
Houille-Vernes, L., Rappaport, F., Wollman, F. A., Alric, J. & Johnson, X. 2011. Plastid terminal oxidase 2 (PTOX2) is the major oxidase involved in chlororespiration in Chlamydomonas. Proc. Natl. Acad. Sci. U. S. A. 108:20820-20825.
DOI
|
139 |
Hu, Z., Li, Y., Sommerfeld, M. & Hu, Q. 2008. Enhanced protection against oxidative stress in an astaxanthin-overproduction Haematococcus mutant (Chlorophyceae). Eur. J. Phycol. 43:365-376.
DOI
ScienceOn
|
140 |
Huang, J. C., Chen, F. & Sandmann, G. 2006a. Stress-related differential expression of multiple -carotene ketolase genes in the unicellular green alga Haematococcus pluvialis. J. Biotechnol. 122:176-185.
DOI
ScienceOn
|
141 |
Huang, J., Liu, J., Li, Y. & Chen, F. 2008. Isolation and characterization of the phytoene desaturase gene as a potential selective marker for genetic engineering of the astaxanthin-producing green alga Chlorella zofingiensis (Chlorophyta). J. Phycol. 44:684-690.
DOI
ScienceOn
|
142 |
Huang, J. C., Wang, Y., Sandmann, G. & Chen, F. 2006b. Isolation and characterization of a carotenoid oxygenase gene from Chlorella zofingiensis (Chlorophyta). Appl. Microbiol. Biotechnol. 71:473-479.
DOI
|
143 |
Ip, P. -F. & Chen, F. 2005b. Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark. Process Biochem. 40:733-738.
DOI
ScienceOn
|
144 |
Huang, J. C., Zhong, Y. J., Sandmann, G., Liu, J. & Chen, F. 2012. Cloning and selection of carotenoid ketolase genes for the engineering of high-yield astaxanthin in plants. Planta 236:691-699.
DOI
ScienceOn
|
145 |
Huss, V. A. R., Frank, C., Hartmann, E. C., Hirmer, M., Kloboucek, A., Seidel, B. M., Wenzeler, P. & Kessler, E. 1999. Biochemical taxonomy and molecular phylogeny of the genus Chlorella sensu lato (Chlorophyta). J. Phycol. 35:587-598.
DOI
|
146 |
Ip, P. -F. & Chen, F. 2005a. Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture. Process Biochem. 40:3491-3496.
DOI
ScienceOn
|
147 |
Ip, P. -F., Wong, K. -H. & Chen, F. 2004. Enhanced production of astaxanthin by the green microalga Chlorella zofingiensis in mixotrophic culture. Process Biochem. 39:1761-1766.
DOI
ScienceOn
|
148 |
Jayaraj, J., Devlin, R. & Punja, Z. 2008. Metabolic engineering of novel ketocarotenoid production in carrot plants. Transgenic Res. 17:489-501.
DOI
ScienceOn
|
149 |
Johnson, E. A. & An, G. -H. 1991. Astaxanthin from microbial sources. Crit. Rev. Biotechnol. 11:297-326.
DOI
|
150 |
Johnson, E. A. & Schroeder, W. A. 1996. Microbial carotenoids. Adv. Biochem. Eng. Biotechnol. 53:119-178.
|
151 |
Kajiwara, S., Fraser, P. D., Kondo, K. & Misawa, N. 1997. Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli. Biochem. J. 324:421-426.
DOI
|
152 |
Gutman, J., Zarka, A. & Boussiba, S. 2011. Evidence for the involvement of surface carbohydrates in the recognition of Haematococcus pluvialis by the parasitic blastoclad Paraphysoderma sedebokerensis. Fungal Biol. 115:803-811.
DOI
ScienceOn
|