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http://dx.doi.org/10.5302/J.ICROS.2005.11.4.353

State-of-the Art Review in Nano-Biomanipulation Technologies  

Kim Deok-Ho (한국과학기술연구원 마이크로시스템연구센터)
Kim Byungkyu (한국과학기술연구원 마이크로시스템연구센터)
Park Jong-Oh (전남대학교 기계시스템공학부)
Ju Byeong-Kwon (고려대학교 전기공학과)
Publication Information
Journal of Institute of Control, Robotics and Systems / v.11, no.4, 2005 , pp. 353-362 More about this Journal
Abstract
This article describes a state-of-the art review in nano-biomanipulation technologies. Nanomanipulation of biological objects enables an in-depth study of single molecules such as DNA and RNA, and of biophysical events at the molecular level like molecular motors. Controlled nanomanipulation is challenging but essential for precisely engineering biomolecules or cells and for manufacturing functional nano-biosystems. In this paper, we summarize several contact, non-contact and hybrid methods available for nanomanipulation of biological objects. Advantages currently available methods and their limitations are also compared. Finally, we discuss possible applications of nano-biomanipulation technologies to life science and molecular medicine including cell biology, genetic engineering, biophysics, and biochemistry.
Keywords
nano-biomanipulation; AFM; optical manipulation; dielectrophretic manipulation; DNA; RNA; protein; molecular motors;
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