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http://dx.doi.org/10.9719/EEG.2015.48.3.199

Development of Antibiotic-intercalated Smectite Composites and Its Drug Delivery Potential in Gastric System  

Song, Yungoo (Department of Earth System Sciences, Yonsei University)
Chung, Donghoon (Department of Earth System Sciences, Yonsei University)
Song, Young Goo (Division of Infectious Diseases, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine)
Choi, Woohyun (Department of Earth System Sciences, Yonsei University)
Publication Information
Economic and Environmental Geology / v.48, no.3, 2015 , pp. 199-204 More about this Journal
Abstract
In this study, we aimed to make antibiotic-intercalated smectite composites using amoxicillin and clarithromycin as hygroscopic antibiotics, and gentamicin, tobramycin and netilmicin as non-hygroscopic aminoglucosides, and to check their drug delivery potential in gastric system using preliminary in-situ column release test for clarithromycinsmectite composite. All antibiotics were successfully intercalated into the interlayer of smectite by cation-exchange reaction in the batch experiment. Equilibrium batch test showed that clarithromycin-intercalation followed Langmuir isotherm and the possible maximum amount was calculated as 1.811 mmole/g. Clarithromycin was continuously released by the solutions of pH=2, 3, and 4 and the amount was decreased with pH increase.
Keywords
antibiotic-smectite composite; drug delivery; smectite; intercalation; Clarithromycin;
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