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Study on the Single Oral Dose Toxicity of High Quality Rice Varieties  

Shin, Jin-Chul (National Institute of Crop Science, Rural Development Administration)
Choi, Sung-Sook (Dept. of Foods and Nutrition, Duksung Women's University)
Han, Hye-Kyoung (Dept. of Foods and Nutrition, Duksung Women's University)
Chung, Ha-Sook (Dept. of Foods and Nutrition, Duksung Women's University)
Publication Information
KOREAN JOURNAL OF CROP SCIENCE / v.52, no.2, 2007 , pp. 146-152 More about this Journal
Abstract
The present study was carried out to investigate the potential acute toxicity of ethanol extracts of the aleurone layer of Oryza sativa cvs. Obongbyeo, Ilpumbyeo, and Aranghyangchalbyeo by a single oral dose in ICR mice. The test article was orally administered once by gavage to male and female mice at dose levels of 0, 2.5, 5.0, and 10.0 g/kg body weight (n=10 for male and female mice for each dose). We examined numbers of deaths, general signs, weight measurement and biochemical analysis for sexes and doses of mice control and experimental groups. All mice were alive during the experimental period so can not yield death rate and $LD_{50}$. Any significant clinical symptom was not observed in all treated groups. No significant body weight changes in treatment groups in comparison with those of control groups was observed at any dose levels in experimental groups. Plasma glucose levels were valued both control and treated groups and there were no significant differences between groups. The activities of ALT and AST were not increase in all sample treated groups when compared with the control groups. The results suggest that the toxicity of Oryza sativa cvs. Obongbyeo, Ilpumbyeo, and Aranghyangchalbyeo are low and its $LD_{50}$ is over 10.0 g/kg body weight in both male and female mice.
Keywords
high quality rice; Obongbyeo; Ilpumbyeo; Aranghyangchalbyeo; ICR mice; single oral dose toxicity; lethal dose; food safety; $LD_{50}$;
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Times Cited By KSCI : 1  (Citation Analysis)
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