Browse > Article
http://dx.doi.org/10.7736/KSPE.2012.29.6.686

A Study on the Fabrication of Various 3D Microstructures using Polymer Deposition System  

Kim, Jong-Young (Department of Mechanical Engineering, Andong National University)
Publication Information
Journal of the Korean Society for Precision Engineering / v.29, no.6, 2012 , pp. 686-692 More about this Journal
Abstract
Solid free-form fabrication (SFF) technology was developed to fabricate three-dimensional (3D) scaffolds for tissue engineering (TE) applications. In this study, we developed a polymer deposition system (PDS) and created 3D microstructures using a bioresorbable polycaprolactone (PCL) polymer. Fabrication of 3D scaffolds by PDS requires a combination of several devices, including a heating system, dispenser, and motion controller. The system can process a polymer with extremely high precision by using a 200 ${\mu}m$ nozzle. Based on scanning electron microscope (SEM) images, both the line width and the piled line height were fine and uniform. Several 3D micro-structures, including the ANU pattern (a pattern named after Andong National University), $45^{\circ}$ pattern square, frame, cylindrical, triangular, cross-shaped, and hexagon, have been fabricated using the polymer deposition system.
Keywords
Solid Free-form Fabrication; Tissue Engineering; Polymer Deposition System; Three-dimensional Microstructure; Polycaprolactone;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Kim, J. Y., Jin, G.-Z., Park, I. S., Kim, J.-N., Chun, S. Y., Park, E. K., Kim, S.-Y., Yoo, J., Kim, S.-H., Rhie, J.-W., and Cho, D.-W., "Evaluation of solid free-form fabrication-based scaffolds seeded with osteoblasts and human umbilical vein endothelial cells for use in vivo osteogenesis," Tissue Eng.: Part A, Vol. 16, No. 7, pp. 2229-2236, 2010.   DOI   ScienceOn
2 Hutmacher, D. W., Sittinger, M., and Risbud, M. V., "Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems," Trends Biotechnol., Vol. 22, No. 7, pp. 354-362, 2004.   DOI
3 Shin, B. S., Yang, S. B., Chang, W. S., Kim, J. G., and Kim, J. M, "Rapid Manufacturing of 3D-Shaped Microstructures by UV Laser Ablation," J. of KSPE, Vol. 21, No. 7, pp. 30-36, 2004.   과학기술학회마을
4 Hutmacher, D. W. and Cool, S., "Concepts of scaffold-based tissue engineering-the rationale to use solid free-form fabrication techniques," J. Cell. Mol. Med., Vol. 11, No. 4, pp. 654-669, 2007.   DOI
5 Lee, M., Dunn, J. C. Y., and Wu, B. M., "Scaffold fabrication by indirect three-dimensional printing," Biomaterials, Vol. 26, No. 20, pp. 4281-4289, 2005.   DOI
6 Mondrinos, M. J., Dembzynski, R., Lu, L., Byrapogu, V. K. C., Wootton, D. M., Lelkes, P. I., and Zhou, J., "Porogen-based solid freeform fabrication of polycaprolactone-calcium phosphate scaffolds for tissue engineering," Biomaterials, Vol. 27, No. 25, pp. 4399-4408, 2006.   DOI
7 Williams, J. M., Adewunmi, A., Schek, R. M., Flanagan, C. L., Krebsbach, P. H., Feinberg, S. E., Hollister, S. J., and Das, S., "Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering," Biomaterials, Vol. 26, No. 23, pp. 4817-4827, 2005.   DOI
8 Lee, S.-J., Kang, H.-W., Kang, T.-Y., Kim, B., Lim, G., Rhie, J.-W., and Cho, D.-W., "Development of a scaffold fabrication system using an axiomatic approach," J. Micromech. Microeng., Vol. 17, No. 1, pp. 147-153, 2007.   DOI   ScienceOn
9 Yang, D.-Y., Lim, T. W., Son, Y., Kong, H.-J., Lee, K.-S., Kim, D.-P., and Park, S. H., "Additive process using femto-second laser for manufacturing three-dimensional nano/micro-structures," Int. J. Precis. Eng. Manuf., Vol. 8, No. 4, pp. 63-69, 2007.   과학기술학회마을
10 Shim, J.-H., Kim, J. Y., Park, M., Park, J., and Cho, D.-W., "Development of a Hybrid Scaffold with Synthetic Biomaterials and Hydrogel Using Solid Freeform Fabrication Technology," Biofabrication, Vol. 3, No. 3, Paper No. 034102, 2011.   DOI   ScienceOn
11 Cooke, M. N., Fisher, J. P., Dean, D., Rimnac, C., and Mikos, A. G., "Use of stereolithography to manuf acture critical-sized 3D biodegradable scaffolds for bone ingrowth," J. Biomed. Mater. Res. B, Vol. 64, No. 2, pp. 65-69, 2002.
12 Wang, F., Shor, L., Darling, A., Khalil, S., Sun, W., and Lau, A., "Precision extruding deposition and characterization of cellular poly-e-caprolactone tissue scaffolds," Rapid Prototyping J., Vol. 10, No. 1, pp. 42-49, 2004.   DOI
13 Zein, I., Hutmacher, D. W., Tan, K. C., and Teoh, S. H., "Fused deposition modeling of novel scaffold architectures for tissue engineering applications," Biomaterials, Vol. 23, No. 4, pp. 1169-1185, 2002.   DOI   ScienceOn
14 Kim, J. Y., Yoon, J. J., Park, E. K., Kim, S. Y., and Cho, D. W., "The Fabrication of Rapid Prototype based 3D PCL and PLGA Scaffolds using Precision Deposition System," Tissue Eng. Regen. Med., Vol. 5, No. 3, pp. 506-511, 2008.
15 Kim, J. Y. and Cho, D.-W., "Development of polymer deposition system for three dimensional scaffold fabrication in tissue engineering," Proc. of KSPE Spring Conference, pp. 1459-1460, 2011.
16 Vozzi, G., Previty, A., Rossi, D., and Ahluwalia, A., "Microsyringe-based deposition of two-dimensional and three-dimensional polymer scaffolds with a well-defined geometry for application to tissue engineering," Tissue Eng., Vol. 8, No. 6, pp. 1089-1098, 2002.   DOI