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Effect of Low Intensity Sound Wave on UC-MSC(Umbilical Cord Mesenchymal Stem Cell Growth  

Kim, Sung-Min (College of Biosystem Department of Medical Bio Engineering, Dongguk Univ.)
Kang, Seung-Ho (College of Biosystem Department of Medical Bio Engineering, Dongguk Univ.)
Jeong, Jae-Hoon (College of Biosystem Department of Medical Bio Engineering, Dongguk Univ.)
Park, Jung-Keug (College of Biosystem Department of Medical Bio Engineering, Dongguk Univ.)
Kim, Soo-Chan (Graduate School of Bio & Information Technology, Hankyong National Univ.)
Publication Information
Journal of the Korean Society for Precision Engineering / v.28, no.4, 2011 , pp. 521-525 More about this Journal
Abstract
It is known that the low-intensity sound stimulation really affect to grow the cell. The cellular growth mechanism, however, does not been clearly identified even the effect on the low-intensity sound stimulation. The purpose of this study is to investigate the effect of low-intensity sound stimulation on the alveolar UC-MSC proliferation. Before the low-intensity sound stimulation is applied, the UC-MSC are cultured for 24 hours to facilitate their attachments. The cells are divided into two groups. And each was exposed to a medium with or without the low-intensity ultrasound stimulation at 71dB intensity level. The UC-MSC are again divided into three treatment groups of group 1, 2, and 3 and exposed to a frequency at 50Hz, 100Hz, and 1000Hz, respectively. In the results, it is investigated that the growth rates of UC-MSC for the stimulated groups were higher than those of control groups. In 1000Hz frequency, the number of UC-MSC cell is significantly higher than control groups (p>0.05). We would put the hypothesis that the cell growth could be enhanced by an appropriate low-intensity sound stimulation.
Keywords
Sound Wave; Stem Cell; Sound Effect; Cell Growth;
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Times Cited By KSCI : 2  (Citation Analysis)
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