A Study of Optimal Lotion Manufacturing Process Containing Angelica gigas Nakai Extracts by Utilizing Experimental Design and Design Space Convergence Analysis
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Pyo, Jae-Sung
(Department of Pharmacy, Kyungsung University)
Kim, Hyun-Jin (R&D center, Naturetech Co., Ltd) Yoon, Seon-hye (R&D center, Naturetech Co., Ltd) Park, Jae-Kyu (Advanced Bio Convergence Center, Pohang Technopark Foundation) Kim, Kang-Min (Department of Pharmaceutical Science and Technology, Kyungsung University) |
1 | Ministry of food and drug safety. (2019). General tests: mass variation test. Retrieved May 15, 2021, (Online). https://www.mfds.go.kr/brd/m_207/view.do?seq=14434&srchFr=&srchTo=&srchWord=&srchTp=&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&company_cd=&company_nm=&page=2 |
2 | Ministry of food and drug safety. (2003). Provision for specifications and test procedures of drugs. The korea food and drug administration notification 2002-43. Retrieved April 23, 2021, (Online). https://mfds.go.kr/brd/m_207/view.do?seq=2192&srchFr=&srchTo=&srchWord=&srchTp=&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&company_cd=&company_nm=&page=204 |
3 | Ministry of food and drug safety. (2007). Regulation on review of specifications and test methods of drugs: specification and test method of weight (volume) variation of drugs. The korea food and drug administration notification 2007-61. Retrieved April 25, 2021, (Online). https://www.law.go.kr/LSW/admRulInfoP.do?admRulSeq=4365 |
4 | European Medicines Agency. (2008). ICH guideline Q10 on pharmaceutical quality system. Retrieved April 23, 2021, (Online). https://www.ema.europa.eu/en/ich-q10-pharmaceutical-quality-system |
5 | J. Y. Kim & K. H. Kwon. (2013). A study on the comparison of korea GMP with PIC/S GMP for enhancing international competency of medicinal product quality. Yakhak Hoeji, 57(6), 432-441. |
6 | A. Chaudhury, D. Barrasso, R. Ramachandran, P. Pandey, H. Wu & R. Ramachandran (2014). Population balance model development, validation, and prediction of CQAs of a high-shear wet granulation process: Towards QbD in drug product pharmaceutical manufacturing. Journal of Pharmaceutical Innovation, 9(1), 53-64. DOI : 10.1007/s12247-014-9172-7 DOI |
7 | S. H. Lee et al. (2021). Whitening and Antioxidant Effects of Extracts from Angelica gigas Nakai Thin Root. Korean Journal of Plant Resources, 34(1), 37-43. DOI : 10.7732/kjpr.2021.34.1.037 DOI |
8 | J. M. Ahn, M. J. Ahn, Y. W. Chin & J. W. Kim (2019). Pharmaceutical studies on "Dang-Gui" in korean journals. Natural Product Sciences, 25(4), 285-292. DOI : 10.20307/nps.2019.25.4.285 DOI |
9 | S. I. Park, S. H. Heo, J. S. Lee & M. S. Shin (2021). Extraction of active compounds from Angelica gigas using supercritical carbon dioxide and its physiological activity. Journal of Convergence for Information Technology, 11(6), 206-212. DOI : 10.22156/CS4SMB.2021.11.06.206 DOI |
10 | European Medicines Agency. (2006). ICH Q9 Quality risk management. Retrieved April 21, 2021, (Online). https://www.ema.europa.eu/en/ich-q9-quality-risk-management |
11 | B. Aksu, A. Paradkar, M. de Matas, O. Ozer, T. Guneri & P. York. (2012). Quality by design approach: application of artificial intelligence techniques of tablets manufactured by direct compression. AAPS PharmSciTech, 13(4), 1138-1146. DOI : 10.1208/s12249-012-9836-x DOI |
12 | R. Bhaumik, N. K. Mondal, S. Chattoraj & J. K. Datta. (2013). Application of response surface methodology for optimization of fluoride removal mechanism by newly developed biomaterial. American Journal of Analytical Chemistry, 4(8), 404-419. DOI : 10.4236/ajac.2013.48051 DOI |
13 | H. Y. Kuk & K. W. Son. (2009). Rheological properties of antiphlamine-S® lotion. Journal of Pharmaceutical Investigation, 39(3), 185-199. DOI : 10.4333/KPS.2009.39.3.185 DOI |
14 | Ministry of food and drug safety. (2016). Regulations on cosmetic good manufacturing and quality control practices. Retrieved May 15, 2021, (Online). https://www.mfds.go.kr/brd/m_641/view.do?seq=22758&srchFr=&srchTo=&srchWord=&srchTp=&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&company_cd=&company_nm=&page=7 |
15 | K. M. Kim. (2021). A study of transdermal permeation of lotion formulation containing Angelica gigas Nakai extracts in franz diffusion cell. Journal of Life Science, 31(11), 1004-1009. DOI : 10.5352/JLS.2021.31.11.1004 DOI |
16 | J. H. Kim, K. W. Song, J. O. Lee & C. H. Lee (1995). Studies on the flow properties of semi-solid dosage forms (I): Steady shear flow behavior of toothpastes. Journal of Pharmaceutical Investigation, 25(3), 213-221. |
17 | European Medicines Agency. (2009). ICH Q8 (R2) Pharmaceutical development. Retrieved March 25, 2021, (Online). https://www.ema.euro pa.eu/en/ich-q8-r2-pharmaceutical-development |
18 | N. S. Kim, D. H. Jung, C. R. Jung, H.-J. Kim, K. S. Jeon & H. W. Park. (2019). Comparison of growth and contents of active ingredients of Angelica gigas Nakai under different cultivation areas. Korean Journal of Plant Resources, 32(5), 448-456. DOI : 10.7732/KJPR.2019.32.5.448 DOI |
19 | H. Y., Ahn K. R. Park & Y. S. Cho. (2014). Effect of fermented Angelica gigas Nakai on lipid metabolism in orotic acid model rats. Journal of Life Science, 24(7), 743-749. DOI : 10.5352/JLS.2014.24.7.743 DOI |
20 | S. E. Jin, M. S. Kim, S. M. Shin, S. H. Jeong & S. J. Hwang. (2014). Current status and understanding of QbD implementation in pharmaceutical industry. FDC Regulatory Sciences, 9(2), 141-148. |
21 | M. H. Choi, Y. W. Kim, M. S. Kim & H. J. Shin. (2016). Development of cosmetic emulsion using blueberry fruit extract and agarose from Gracilaria verrucosa. The Korean Society for Biotechnology and Bioengineering, 31(4), 256-262. DOI : 10.7841/ksbbj.2016.31.4.256 DOI |
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