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http://dx.doi.org/10.22156/CS4SMB.2022.12.03.132

A Study of Optimal Lotion Manufacturing Process Containing Angelica gigas Nakai Extracts by Utilizing Experimental Design and Design Space Convergence Analysis  

Pyo, Jae-Sung (Department of Pharmacy, Kyungsung University)
Kim, Hyun-Jin (R&D center, Naturetech Co., Ltd)
Yoon, Seon-hye (R&D center, Naturetech Co., Ltd)
Park, Jae-Kyu (Advanced Bio Convergence Center, Pohang Technopark Foundation)
Kim, Kang-Min (Department of Pharmaceutical Science and Technology, Kyungsung University)
Publication Information
Journal of Convergence for Information Technology / v.12, no.3, 2022 , pp. 132-140 More about this Journal
Abstract
This study was conducted to identify the optimal lotion manufacturing conditions with decursin and decursinol angelate of Angelica gigas Nakai extraction. Lotion was confirmed that it had viscosity (5,208±112 cPs), assay (99.71±1.01%), and pH (5.62) for 3 months. The optimization of manufacturing conditions of mixing 4 for lotion formulation were made by 22+3 full factorial design. Mixing temperature (40-80℃) and mixing time (10-30 min) were used as independent variables with three responses(assay, pH, and weight variation) as critical quality attributes (CQAs). The model for assay and weight variation identified a proper fit having a determination coefficient of the regression equation (about 0.9) and a p-value less than 0.05. Estimated conditions for the optimal manufacturing process of lotion were 61.93℃ in mixing temperature and 15.85 min in mixing time. Predicted values at the mixing temperature (60℃) and mixing time (20 min) were 100.69% of assay, 5.57 of pH, and 98.07% of weight variation. In the verification of the actual measurement the obtained values showed 100.29±0.98% of assay, 5.57±0.02 of pH, and 98.27±0.89% of weight variation, respectively, in good agreement with predicted values.
Keywords
Decursin; Decursinol angelate; Quality by design; Design of experiments; Convergence analysis; Angelica gigas Nakai;
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Times Cited By KSCI : 5  (Citation Analysis)
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