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http://dx.doi.org/10.22156/CS4SMB.2021.11.08.201

Antioxidative Effect of Stachys japonica Miq Extract on Cultured NIH3T3 Fibroblasts Damaged by Ferrous chloride, Mordant  

Sohn, Young-Woo (Divsion of Medicine School, Sanbon Hospital, Wonkwang University)
Yoo, Sun-Mi (Dept. of Beauty & Cosmetics, Wonkwang Health Science University)
Publication Information
Journal of Convergence for Information Technology / v.11, no.8, 2021 , pp. 201-206 More about this Journal
Abstract
The aim of this study was to examined the dermatoxicity of ferrous chloride (FeCl2) and the antioxidative effect of Stachys japonica Miq (SJ) extract on FeCl2-induced cytotoxicity. For this study, superoxide anion-radical (SAR)-scavenging and superoxide dismutase (SOD)-like abilities with cell viability were done. FeCl2 showed a significant decrease of cell viability in dose-dependent manner, and it was mid-toxic. The caffeic acid showed a significant increase of cell viability against FeCl2-induced cytotoxicity. In the protective effect of SJ extract on FeCl2-induced cytotoxicity, it showed SAR-scavenging and SOD-like abilities with a significant increase of cell viability. From these results, the cytotoxicity of FeCl2 is correlated with oxidative stress, and SJ extract effectively protected the cytotoxicity of FeCl2 by antioxidative effect. Conclusively, the natural resources like SJ extract may be a useful fundamental materials for the development of an alternative antioxidant.
Keywords
Ferrous chloride(FeCl2); Mordant; Cell viability; Antioxidative effect; Natural resources;
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