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http://dx.doi.org/10.22156/CS4SMB.2021.11.06.206

Extraction of Active Compounds from Angelica gigas using Supercritical Carbon Dioxide and its Physiological Activity  

Park, Su In (Dept. of Senior Healthcare majoring in Cosmetic Pharmacology, Eulji University)
Heo, Soo Hyeon (Dept. of Senior Healthcare majoring in Cosmetic Pharmacology, Eulji University)
Lee, Jinseo (Dept. of Senior Healthcare majoring in Cosmetic Pharmacology, Eulji University)
Shin, Moon Sam (Dept. of Senior Healthcare majoring in Cosmetic Pharmacology, Eulji University)
Publication Information
Journal of Convergence for Information Technology / v.11, no.6, 2021 , pp. 206-212 More about this Journal
Abstract
This study aimed to maximize the efficacy of Angelica gigas by finding a more effective way to extract active compounds from Angelica gigas. After extracting Angelica gigas by hydrothermal, ethanol, and supercritical carbon dioxide extraction methods, analysis of decursin and decursinol angelate content, quantification of total polyphenol content, and evaluation of efficacy of antioxidant, whitening, and antibacterial were conducted. The content of decursin and decursinol angelate was very high at 38.65% of the supercritical carbon dioxide extract, and the total polyphenol content was high in the order of hydrothermal extract, ethanol extract and supercritical carbon dioxide extract, but the difference was relatively small. The antioxidant effects were consistent with the total polyphenol content, and the antibacterial effects were consistent with the decursin and decursinol angelate content. In other words, through this study, we found that the optimal method for extracting active compounds from Angelica gigas is the supercritical carbon dioxide extraction method.
Keywords
Angelica gigas; Supercritical extraction; Decursin; Decursinol angelate; Antibacterial;
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1 A. K. Lim, J. O. Kim, M. J. Jung, H. K. Jung, J. H. Hong, & D. I. Kim. (2008). Functional biological activity of hot water and ethanol extracts from Taraxaci Herba. Journal of the Korean Society of Food Science and Nutrition, 37(10), 1231-1237. DOI : 10.3746/jkfn.2008.37.10.1231   DOI
2 C. G. Pereira, M. & A. A. Meireles. (2010). Supercritical fluid extraction of bioactive compounds: fundamentals, applications and economic perspectives. Food and Bioprocess Technology, 3(3), 340-372. DOI : 10.1007/s11947-009-0263-2   DOI
3 J. L. Hedrick, L. J. Mulcahey, & L. T. Taylor. (1992). Supercritical fluid extraction. Microchimica Acta, 108(3), 115-132. DOI : 10.1007/BF01242421   DOI
4 P. A. Uwineza & A. Wa kiewicz. (2020). Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials. Molecules, 25(17), 3847. DOI: 10.3390/molecules25173847   DOI
5 R. Badal. (2002). Supercritical carbon dioxide extraction of lipids from raw and bioconverted rice bran. Master's thesis. Regional Engineering College, Jalandhar.
6 R. L. Mendes, B. P. Nobre, M. T. Cardoso, A. P. Pereira, & A. F. Palavra. (2003). Supercritical carbon dioxide extraction of compounds with pharmaceutical importance from microalgae. Inorganica Chimica Acta, 356, 328-334. DOI : 10.1016/S0020-1693(03)00363-3   DOI
7 S. Liu, F. Yang, C. Zhang, H. Ji, P. Hong, & C. Deng. (2009). Optimization of process parameters for supercritical carbon dioxide extraction of Passiflora seed oil by response surface methodology. The Journal of Supercritical Fluids, 48(1), 9-14. DOI : 10.1016/j.supflu.2008.09.013   DOI
8 S. K. Cho, A. M. Abd El-Aty, J. H. Choi, M. R. Kim, & J. H. Shim. (2007). Optimized conditions for the extraction of secondary volatile metabolites in Angelica roots by accelerated solvent extraction. Journal of Pharmaceutical and Biomedical Analysis, 44(5), 1154-1158. DOI : 10.1016/j.jpba.2007.03.011   DOI
9 K. S. Ahn, W. S. Sim, H. M. Kim, S. B. Han, & I. H. Kim. (1996). Immunostimulating components from the root of Angelica gigas Nakai. Korean Journal of Pharmacognosy, 27(3), 254-261.
10 M. E. Paulaitis, V. J. Krukonis, R. T. Kurnik, & R. C. Reid. (1983). Supercritical Fluid Extraction. Reviews in chemical engineering, 1(2), 179-250.
11 O. Folin & W. Denis. (1912). On phosphotungstic-phosphomolybdic compounds as colorreagents. Journal of Biological Chemistry, 12(2), 239-243. DOI : 10.1016/S0021-9258(18)88697-5   DOI
12 M. S. Blois. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199-1200. DOI : 10.1038/1811199a0   DOI
13 R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, & C. Rice-Evans. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free radical biology and medicine, 26(9-10), 1231-1237. DOI : 10.1016/S0891-5849(98)00315-3   DOI
14 I. Kubo & I. Kinst-Hori. (1999). Flavonols from saffron flower: tyrosinase inhibitory activity and inhibition mechanism. Journal of agricultural and food chemistry, 47(10), 4121-4125. DOI : 10.1021/jf990201q   DOI
15 M. O. Ko, H. J. Kang, J. H. Hwang, & K. W. Yang. (2018). Screening of the antibacterial effects by ethanol extracts from natural plant in Jeju against Propionibacterium acnes. Journal of the Society of Cosmetic Scientists of Korea, 44(1), 59-66. DOI : 10.15230/SCSK.2018.44.1.59   DOI
16 J. H. Lee, Y. S. Choi, J. H. Kim, H. G. Jeong, D. H. Kim, M. Y. Yun, & G. Y. Song. (2006). A mass preparation method of (+)-decursinol from the roots of Angelica gigas. Yakhak Hoeji, 50(3), 172-176.
17 C. A. Rice-Evans, N. J. Miller, & G. Paganga. (1996). Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free radical biology and medicine, 20(7), 933-956. DOI : 10.1016/0891-5849(95)02227-9   DOI
18 E. Reverchon. (1997). Supercritical fluid extraction and fractionation of essential oils and related products. The Journal of Supercritical Fluids, 10(1), 1-37. DOI : 10.1016/S0896-8446(97)00014-4   DOI
19 Y. S. Lee, J. B. Choi, E. Y. Joo, & N. W. Kim. (2007). Antioxidative activities and tyrosinase inhibition of water extracts from Ailanthus altissima. Journal of the Korean Society of Food Science and Nutrition, 36(9), 1113-1119. DOI : 10.3746/jkfn.2007.36.9.1113   DOI
20 K. W. Park et al. (2007). Cytotoxic effects of decursin from Angelica gigas Nakai in human cancer cells. Journal of the Korean Society of Food Science and Nutrition, 36(11), 1385-1390. DOI : 10.3746/jkfn.2007.36.11.1385   DOI
21 J. H. Kwon, M. S. Han, B. M. Lee, & Y. M. Lee. (2015). Effect of Angelica gigas extract powder on progress of osteoarthritis induced by monosodium iodoacetate in rats. Analytical Science and Technology, 28(1), 72-77. DOI : 10.5806/AST.2015.28.1.72   DOI