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http://dx.doi.org/10.22156/CS4SMB.2021.11.04.194

Anti-oxidant, Anti-inflammatory, and Wound Healing Activities of Selaginella tamariscina Leaf Extract  

Kim, Yu-Jin (Dept. of Beauty Art, Graduate School, Seokyeong University)
Lee, Ji-An (Dept. of Beauty Art, Graduate School, Seokyeong University)
Publication Information
Journal of Convergence for Information Technology / v.11, no.4, 2021 , pp. 194-202 More about this Journal
Abstract
The leaves of Selaginella tamariscina were used for the treatment of many diseases in traditional medicine. In the study, antioxidant, anti-inflammatory, and wound healing activities of the hot-water extract(STW) and 80%ethanol extract(STE) obtained from S. tamariscina were evaluated. As a result, the polyphenol content of STW and STE were 38.108±0.766 mg/g and 17.927±1.064 mg/g, respectively. The DPPH and ABTS radical scavenging activities with the IC50 values of the STW were over 2 times lower than that of the STE. In the MTT assay, RAW264.7 cell viability of two extracts was decreased by about 6% at 1 mg/mL, whereas for HaCaT cell viability increased by 18% at 50 ㎍/mL. In addition, STW and STE suppressed the production of nitric oxide(NO), Tumor-necrosis(TNF)-��. COX-2 and PGE2 in lipopolysaccharide(LPS) induced RAW264.7 cells. Furthermore, the STE showed wound healing effect through the promotion of skin cell migration in TNF-�� stimulated human keratinocytes. These results indicated that the STW and STE have the potential to be used as a new cosmetic active ingredients in skin care.
Keywords
Selaginella tamariscina; Anti-oxidant; Anti-inflammation; Wound healing; Cosmetic material;
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