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http://dx.doi.org/10.22156/CS4SMB.2018.8.5.045

A Study on the Fluorescence Characteristics of Dye-doped Silica Nanoparticles for Integrated Bio Imaging  

Kim, Ki-Chul (Department of Advanced Chemical Engineering, Mokwon University)
Publication Information
Journal of Convergence for Information Technology / v.8, no.5, 2018 , pp. 45-50 More about this Journal
Abstract
The functional nanomaterials of fluorescent dye-doped silica nanoparticles(NPs) are applied to bio applications such as bio-labeling of DNA micro-array, and bio-imaging. Organic dye-doped fluorescent silica NPs exhibit excellent bio-compatibility, non-toxic, and highly hydrophilic properties. In this study, organic fluorescent dyes were dissolved in ethanol, and deionized(DI) water. Organic fluorescent dyes were physically adsorbed to silica NPs and chemically doped to silica NPs. The fluorescence characteristics(FLC) was investigated by UV lamp irradiation of 365 nm wavelength. As results, the FLC of dye-doped silica NPs exhibits better than dye-adsorbed silica NPs and the FLC was improved with the increase of concentration of doped-dyes. The fluorescent organic dyes were well dissolved in ethanol than DI water. The photostability of dye-doped silica NPs was superior than pure fluorescent organic dye. The FLC of optimized dye-doped silica NPs would be applied to agent of non-invasive fluorescence bio-imaging in live cell and in vivo.
Keywords
Silica; Nanoparticles; Dye-Doped; Fluorescence Characteristics; Bio-Imaging;
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