Browse > Article
http://dx.doi.org/10.22156/CS4SMB.2017.7.6.089

Screening of Natural Compounds for Cancer Prevention by Cytotoxicities and AP-1 Reporter Gene Activities  

Choi, Bu-Young (Department of Pharmaceutical Science & Engineering, Seowon University)
Cho, Seok-Cheol (Department of Food Science & Engineering, Seowon University)
Publication Information
Journal of Convergence for Information Technology / v.7, no.6, 2017 , pp. 89-95 More about this Journal
Abstract
Cancer-inducing PMA stimulates cells to increase the expression of transcription factor c-Jun/c-fos and then increase the activity of AP-1 in the nucleus. The activity of AP-1 has been reported to cause cancer. In this study, We conducted cytotoxicity experiments to assess the safety of natural marker compounds and also observed inhibition of activator protein(AP-1) activity to predict cancer-preventing effects. The results of this experiment indicated that arctigenin, manassantin A, and B can predict the development of cancer prevention agents.
Keywords
Natural Compounds; PMA(Phorbol 12-myristate 13-acetate); Cell cytotoxicity; AP-1 reporter gene; Cancer prevention;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Y. Ma, H. K. Min, U. Oh, A. M. Hawkridge, W. Wang, A. A. Mohsin, Q. Chen, A. Sanyal, E. J. Lesnefsky & X. Fang. (2017). The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals. Journal of Biological Chemistry, Jbc-M117. DOI : 10.1074/jbc.M117.812925   DOI
2 Products-Promega Corporation. (2017). Cell Viability and Cytotoxicity Assays. Promega. https://www.promega.kr
3 J. Y. Jeong, E. H. Hong, S. Y. Lee, J. Y. Lee, J. H. Song, S. H. Ko, J. S. Shim, S. Choe, D. D. Kim, H. J. Ko & H. J. Cho. (2017). Boronic acid-tethered amphiphilic hyaluronic acid derivative-based nanoassemblies for tumor targeting and penetration. Acta Biomaterialia. 53, 414-426. DOI : 10.1016/j.actbio.2017.02.030   DOI
4 F. Lai, Q. Liu, X. Liu, M. Ji, P. Xie & X. Chen. (2016). LXY6090-a novel manassantin A derivative-limits breast cancer growth through hypoxia-inducible factor-1 inhibition. Onco Targets and Therapy. issue 1, 3829-3840. DOI : 10.2147/ott.s106925   DOI
5 S. Y. Song, I. K. Lee, C. H. Park, H. Lee, J. C. Hahm & W. K. Kang. (2015). Neolignans from Saururus chinensis inhibit PC-3 prostate cancer cell growth via apoptosis and senescence-like mechanisms. International Journal of Molecular Medicine, 16(4), 517-524.
6 Y. Okazaki, N. V. Sitanggang, S. Sato, N. Ohnishi, J. Inoue, T. Inoue, T. Lguchi, T. Watanabe, H. Tomotake, K. Harada & N. Kato. (2013). Burdock Fermented by Aspergillus awamori Elevates Cecal Bifidobacterium, and Reduces Fecal Deoxycholic Acid and Adipose Tissue Weight in Rats Fed a High-Fat Diet. Bioscience, Biotechnology and Biochemistry, 77(1), 53-79. DOI : 10.1271/bbb.120551   DOI
7 E. K. Kim, G. S. Lee, O. H. Chae & C. H. Song. (2004). Inhibitory Effect of Arctium lappa Linne on Compound 48/80-induced Mast Cell Activation and Vascular Permeability. Korean Journal of Physical Anthropologists, 17(1), 55-66. DOI : 10.11637/kjpa.2004.17.1.55   DOI
8 S. C. Chae, E. S. Seo, G. C. Ryu, M. S. Na, I. S. Kim & E. G. Kho. (2009). Inhibitory effect of naringenin on MMP9 activity and expression in HT-1080 cells. Korean Journal of Environmental Biology, 27(1), 58-65.
9 P. Angel, M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich & M. Karin. (1987). Phobol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell, 49, 729-739. DOI : 10.1016/0092-8674(87)90611-8   DOI
10 W. Boyle, T. Smeal, L. H. Defize, P. Angel, J. R. Woodgett, M. Karin & T. Hunter. (1991). Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell, 64, 573-584. DOI : 10.1016/0092-8674(91)90241-p   DOI
11 M. E. Greenberg & E. B. Ziff. (1984). Stimulation of 3T3 cells induce stranscription of the c-fos proto oncogene. Nature, 311, 433-438. DOI : 10.1038/311433a0   DOI
12 J. S. Min & D. S. Lee. (2015). A Screen for Dual-protection Molecules from a Natural Product Library against Neuronal Cell Death and Microglial Cell Activation. Journal of Life Science, 25(6), 656-662. DOI : 10.5352/JLS.2015.25.6.656   DOI
13 Y. Murakami, M. Satake, I. Yamaguchi, M. Sakai, M. Muramatsu & Y. Ito. (1991). The nuclear protooncogenes C-jun and C-fos as regulators of DNA replication. Proceedings of the National Academy of Sciences USA. 88, 3947-3951. DOI : 10.1073/pnas.88.9.3947   DOI
14 K. Kovary & R. Bravo. (1991). The Jun and Fos protein families are both required for cell cycle progression in fibroblast. Molecular Cell Biology, 11(9), 4466-4472. DOI : 10.1128/mcb.11.9.4466   DOI
15 E. Shaulian & M. Karin. (2002). AP-1 as a regulator of cell life and death. Nature Cell Biology, 4(5), E131-E136. DOI : 10.1038/ncb0502-e131   DOI
16 G. Zhou, F. Peng, Y. Zhong, Y. Chen, M. Tang & D. Li. (2017). Rhein suppresses matrix metalloproteinase production by regulating the Rac1/ROS/MAPK/AP-1 pathway in human ovarian carcinoma cells. Internal Journal of Oncology, 50(3), 933-941. DOI : 10.3892/ijo.2017.3853   DOI
17 E. K. Radhakrishnan, S. V. Bava, S. S. Narayanan, L. R. Nath, A. K. Thulasidasan, E. V. Soniya & R. J. Anto. (2014). Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLOS One, 9(8), e104401. DOI : 10.1371/journal.pone.0104401   DOI
18 Z. Yang, H. Luo, H. Wang & H. Hou. (2008). Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine ChanSu. Journal of Chromatographic Science, 46(1), 81-85. DOI : 10.1093/chromsci/46.1.81   DOI