[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4313/JKEM.2006.19.10.960

A Study on Gene Detection using Non-labeling DNA

Choi Yong-Sung (Department of Electrical Engineering, Dongshin University)
Lee Kyung-Sup (Department of Electrical Engineering, Dongshin University)
Kwon Young-Soo (Department of Electrical Engineering, Donga University)

Publication Information

Journal of the Korean Institute of Electrical and Electronic Material Engineers / v.19, no.10, 2006 , pp. 960-965 More about this Journal

Abstract

This research aims to develop the multiple channel electrochemical DNA chip using microfabrication technology. At first, we fabricated a high integration type DNA chip array by lithography technology. Several probe DNAs consisting of thiol group at their 5-end were immobilized on the gold electrodes. Then target DNAs were hybridized and reacted. Cyclic voltammetry showed a difference between target DNA and control DNA in the anodic peak current values. Therefore, it is able to detect a plural genes electrochemically after immobilization of a plural probe DNA and hybridization of non-labeling target DNA on the electrodes simultaneously. It suggested that this DNA chip could recognize the sequence specific genes.

Keywords

Multi-channel DNA chip; Microfabrication technology; Photo-lithography technology; Target DNA; Non-labeling;

Citations & Related Records

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