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http://dx.doi.org/10.1186/s42649-020-00031-w

Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse

Yong Soo Park (Department of Anatomy, College of Medicine, The Catholic University of Korea)
Yeonji Kim (Department of Anatomy, College of Medicine, The Catholic University of Korea)
Sung Won Kim (Department of Otolaryngology-Head and Neck Surgery, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea)
In-Beom Kim (Department of Anatomy, College of Medicine, The Catholic University of Korea)

Publication Information

Applied Microscopy / v.50, no., 2020 , pp. 11.1-11.3 More about this Journal

Abstract

The human turbinate-derived mesenchymal stem cells (hTMSCs), which were DiI-labeled and transplanted into the subretinal space in degenerating mouse retina, were observed in retinal vertical sections processed for rhodopsin (a marker for rod photoreceptor) by confocal microscope with differential interference contrast (DIC) filters. The images clearly demonstrated that DiI-labeled hTMSCs have rhodopsin-immunoreactive appendages, indicating differentiation of transplanted hTMSC into rod photoreceptor. Conclusively, the finding suggests therapeutic potential of hTMSCs in retinal degeneration.

Keywords

Human turbinate-derived mesenchymal stem cell; Rod photoreceptor; Retinal degeneration; Confocal microscope; Differential interference contrast;

Citations & Related Records

Reference

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