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The Oxytocinergic Neurons in Hypothamo-hypophysial Tract Contributes to CNS Pathway Innervating Ovary in Rat  

Byun, Kyung-Hee (Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science)
Oh, Jee-Hyun (Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science)
Jo, Seung-Mook (Department of Anatomy, Gachon University of Medicine and Science)
Lee, Bong-Hee (Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science)
Publication Information
Applied Microscopy / v.40, no.4, 2010 , pp. 211-218 More about this Journal
Abstract
The mammalian ovary is innervated by sympathetic and sensory neurons which contribute to regulating several aspects of ovarian function, including blood flow, steroidogenesis and follicular development. The existence of a neural connection between central neurons and the ovary has been rarely reported, but the mechanism underlying integration of ovarian activity to broader neuroendocrine responses has not been reported. We have now used a viral transneuronal tracing technique combined with a conventional retrograde labeling procedure of CT-HRP to demonstrate that oxytocin-producing neurons of the hypothalamus are synaptically connected to the ovary. Since ovarian activity is suppressed but the activity of oxytocin neurons is increased during breast feeding. Our finding that the oxytocinergic neural connection is likely to provide a direct transsynaptic mechanism by which the central nervous system maintains the state of infertility that accompanies lactation in mammals.
Keywords
Ovary; Pituitary; Oxytocinergic neurons; CNS pathway; Pseudorabies virus;
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1 Gerendai I, Toth IE, Boldogkoi Z, Halasz B: Recent findings on the organization of central nervous system structures involved in the innervation of endocrine glands and other organs; observations obtained by the transneuronal viral double-labeling technique. Endocrine 36(2) : 179-188, 2009.   DOI   ScienceOn
2 Kawakami M, Kubo K, Uemura T, Nagase M, Hayashi R: Involvement of ovarian innervation in steroid secretion. Endocrinol 109 : 136-145, 1981.   DOI   ScienceOn
3 Toth IE, Banczerowski P, Boldogkoi Z, Toth JS, Szabo A, Halasz B, Gerendai I: Cerebral neurons involved in the innervation of both the adrenal gland and the ovary: A double viral tracing study. Brain Res Bull 77(5) : 306-311, 2008.   DOI   ScienceOn
4 Safarinejad MR: Reproductive hormones and hypothalamic-pituitary- ovarian axis in female patients with homozygous beta-thalassemia major. J Pediatr Hematol Oncol 32(4) : 259-266, 2010.   DOI
5 Ojeda SR, Aguado L: Catecholamines as Hormone Regulators. Raven Press, New York, pp. 293-310, 1985.
6 Ojeda SR, Lara HE: The Menstrual Cycle and Its Disorders. Springer- Verlag, Berlin, pp. 26-32, 1989.
7 Ricu M, Paredes A, Greiner M, Ojeda SR, Lara HE: Functional development of the ovarian noradrenergic innervation. Endocrinol 149(1) : 50-56, 2008.
8 Saper CB, Loewy AD, Swanson LW, Cowan WM: Direct hypothalamo- autonomic connections. Brain Res 117 : 305-312, 1976.   DOI   ScienceOn
9 Sirotkin AV: Effect of two types of stress (heat shock/high temperature and malnutrition/serum deprivation) on porcine ovarian cell functions and their response to hormones. Exp Biol 213 : 2125-2130, 2010.   DOI   ScienceOn
10 Toth IE, Wiesel O, Boldogkoi Z, Balint K, Tapaszti Z, Gerendai I: Predominance of supraspinal innervation of the left ovary. Microsc Res Tech 70(8) : 710-718, 2007.   DOI   ScienceOn
11 Wakerley JB, Clarke G: Milk ejection and its control. The Physiology of Reproduction. Raven Press, New York, pp. 1131-1177, 1994.
12 Jansen ASP, Van Nguyen X, Karpitskiy V, Mettenleiter TC, Loewy AD: Central command neurons of the sympathetic nervous system: Basis of the fight-or-flight response. Science 270 : 644-646, 1995.   DOI
13 Kalantaridou SN, Zoumakis E, Makrigiannakis A, Lavasidis LG, Vrekoussis T, Chrousos GP: Corticotropin-releasing hormone, stress and human reproduction: an update. J Reprod Immunol 85(1) : 33-39, 2010.   DOI   ScienceOn
14 Loewy AD: Viral Vectors. Academic Press, New York, pp. 349- 366, 1995.
15 Madekurozwa MC: An immunohistochemical study of ovarian innervation in the emu (Dromaius novaehollandiae). Onderstepoort J Vet Res 75(1) : 59-65, 2008.
16 Marshall JM: Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology. Ergebn Physiol 62 : 6-67, 1970.   DOI
17 Burden HW: The Vertebrate Ovary: Comparative Biology and Evolution. Plenum Press, New York, pp. 615-638, 1978.
18 McNeilly AS: Suckling and the control of gonadotropin secretion: The Physiology of Reproduction. Raven Press, New York, pp. 1179-1212, 1994.
19 Morales L, Ricardo B, Bolanos A, Chavira R, Domínguez R: Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses. Reprod Biol Endocrinol 13 : 5-24, 2007.
20 Baljet B, Drukker J: The extrinsic innervation of the abdominal organs in the female rat. Acta Anat 104 : 24-267, 1979.
21 Card JP, Rinaman L, Lynn RB, Lee BH, Meade RP, Miselis RR, Enquist LW: Pseudorabies virus infection of the rat central nervous system: Ultrastnuctural characterization of viral replication, transport, and pathogenesis. J Neurosci 13 : 2515-2539, 1993.
22 Dees WL, Hiney JK, McArthur NH, Johnson GA, Dissen GA, Ojeda SR: Origin and ontogeny of mammalian ovarian neurons. Endocrinol 147(8) : 3789-3796, 2006.   DOI   ScienceOn
23 Delgado SM, Casais M, Sosa Z, Rastrilla AM: Ganglionic adrenergic action modulates ovarian steroids and nitric oxide in prepubertal rat. Endocr J 53(4) : 547-554, 2006.   DOI   ScienceOn
24 Delgado SM, Escudero CG, Casais M, Gordillo M, Anzulovich AC, Sosa Z, Rastrilla AM: Ovaric physiology in the first oestral cycle: influence of noradrenergic and cholinergic neural stimuli from coeliac ganglion. Steroids 75(10) : 685-694, 2010.   DOI   ScienceOn
25 Hsueh AJW, Adashi EY, Jones PBC, Welsh TH Jr: Hormonal regulation of the differentiation of cultured ovarian granulosa cells. Endocr Rev 5 : 76-127, 1984.   DOI   ScienceOn
26 Gerendai I, Toth IE, Boldogkoi Z, Medveczky I, Halasz B: Neuronal labeling in the rat brain and spinal cord from the ovary using viral transneuronal tracing technique. Neuroendocrinol 68(4) : 244-256, 1998.   DOI   ScienceOn