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Protective Effect of Lithospermum erythrorhizon on Galactosamine Induced Liver Injury  

Lee, Hyun-Hwa (Department of Biology, College of Natural Sciences, Chosun University)
Yoon, Jung-Sik (Bio Control Center)
Song, Seon-Young (Department of Skin and Beauty, Gwangju Health College University)
Publication Information
Applied Microscopy / v.40, no.1, 2010 , pp. 29-35 More about this Journal
Abstract
The present study was carried out to investigate the hepatoprotective effect of water extract of Lithospermum erythrorhizon on acute hepatotoxicity induced in Sprague-Dawley (SD) rats by a single dose of galactosamine (400 mg/kg, i.p). The animals were divided into four groups. The animals in the Con group were fed basal diet. GalN group were administered with galactosamine. LE200 and LE500 groups treated with water extract of Lithospermum erythrorhizon (such as 200 and 500 mg/kg/day, p.o) for 7 days before galactosamine injection. In the change of AST, ALT, ALP, GGT and LDH contents, as compared with GalN group, LE200 group were significantly decreased. According to the electron microscopical observation, liver cells were increased the lipid droplet, change of mitochondria in the GalN compared with LE200. These results suggest that administration of water extract of Lithospermum erythrorhizon suppress or retard galactosamine induced acute liver injury.
Keywords
ALP; ALT; Galactosamine; GGT; Lithospermum erythrorhizon; liver injury;
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