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Studies on the Therapeutic Effect and Mechanism of Korean Red Ginseng Total Saponin on Infertility Caused by Polycystic Ovaries  

Kim, Se-Eun (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Oh, Dong-Min (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Sim, Kyung-Mi (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Jeong, Moon-Jin (Department of Oral Histology, College of Dentistry, Chosun University)
Lim, Sung-Chul (Department of Pathology and Research Center for Resistant Cells, College of Medicine, Chosun University)
Nah, Seung-Yeol (Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University)
Lee, Yun-Lyul (Department of Physiology, Hallym University College of Medicine)
Kang, Seong-Soo (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Moon, Chang-Jong (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Kim, Jong-Choon (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Kim, Sung-Ho (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Bae, Chun-Sik (College of Veterinary Medicine, Animal Medical Institute, Chonnam National University)
Publication Information
Applied Microscopy / v.39, no.1, 2009 , pp. 1-7 More about this Journal
Abstract
Experimental induction of polycystic ovary (PCO) resembling some aspects of human PCO syndrome was produced using the long-acting compound estradiol valerate (EV). Our previous study on the role of Korean red ginseng total saponins (GTS) in a steroid-induced PCO rat model demonstrated that electro-acupuncture modulates nerve growth factor (NGF) concentration in the ovaries. In fact, the involvement of a neurogenic component in the pathology of PCO-related ovarian dysfunction is preceded by an increase in sympathetic outflow to the ovaries. In the present study, we tested the hypothesis that therapeutic GTS administration modulates sympathetic nerve activity in rats with PCO. This was done by analyzing NGF protein and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. EV injection resulted in significantly higher ovarian NGF mRNA expression in PCO rats compared to control rats, and PCO ovaries were counteracted by GTS administration with significantly lower expression of NGF mRNA compared to EV treated ovaries. However, NGF protein was unaffected in both EV and GTS treated ovaries compared to control rats. These results indicate that EV modulates the neurotrophic state of the ovaries, which may be a component of the pathological process by which EV induces cyst formation and anovulation in rodents.
Keywords
Polycystic ovary; Estradiol valerate; Pathophysiology; Ginseng saponins;
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