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Therapeutic Effects of Safflower (Carthamus tinctorius L.) Seed Powder on Osteoporosis  

Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University)
Park, Chang-Hyun (Electron Microscope Laboratory, College of Medicine, Korea University)
Cho, Hyung-Jin (College of Veterinary Medicine, Chonnam National University)
Han, Hye-Jeong (College of Veterinary Medicine, Chonnam National University)
Kang, Seong-Soo (College of Veterinary Medicine, Chonnam National University)
Choi, Seok-Hwa (College of Veterinary Medicine, Chungbuk National University)
Uhm, Chang-Sub (Dept. of Anatomy, Institute of Human Genetics, College of Medicine, Korea University)
Publication Information
Applied Microscopy / v.32, no.3, 2002 , pp. 285-290 More about this Journal
Abstract
The therapeutic effect of safflower seed powder on experimental osteoporosis in the rat induced by ovariectomy was evaluated. Thirty Sprague-Dawley rats were ovariectomized at the age of 12 weeks. Seven weeks postovariectomy, rats were divided into two groups: control and safflower seed powder treated group. Five animals from each group were sacrificed at the following time points: 1, 3, and 5 weeks. Scanning electron microscopic observation and morphometric analysis of the tibiae epiphysis showed that the administration of safflower seed powder significantly prevented reduction of cortical bone width and bone volume compared with the control group. In conclusion, safflower seed powder contains something that prevent bone loss due to estrogen deficiency, and was effective in preventing the osteoporotic decrease of bone mass.
Keywords
Ovariectomy; Safflower seed powder; Morphometric analysis; Bone mass;
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