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http://dx.doi.org/10.5229/JKES.2007.10.3.190

Electrochemical Determination of Epinephrine Using Doubly Modified Electrodes with Ni(II)-Macrocyclic Complex and Polyuretane  

Xu, Guang-Ri (Henan Institude of Science and Technology)
Cho, Hyung-Hwa (Department of Chemistry, Kyungpook National University)
Kweon, Soo-Geong (Department of Chemistry, Kyungpook National University)
Lee, Sang-Hag (Department of Chemistry, Kyungpook National University)
Bae, Zun-Ung (Department of Chemistry, Kyungpook National University)
Publication Information
Journal of the Korean Electrochemical Society / v.10, no.3, 2007 , pp. 190-195 More about this Journal
Abstract
A new electrochemical sensor to selectively determine epinephrine was developed and its analytical characteristics has been investigated. A glassy carbon electrode was modified with Ni(II)-macrocyclic complex which has electrocatalytic effect. It was further modified with physiologically suitable and negatively charged polyuretane benzyl L-glutamate(PUBLG). The present electrode showed long term stability and it could be applied to the selective determination of epinephrine in urine sample with various coexisting compounds. Under the optimum experimental conditions the linear range was $8.0\;{\times}\;10^{-7}\;-\;2.0\;{\times}\;10^{-4}\;M$ and the limit of detection was $1.0\;{\times}\;10^{-7}\;M$. The recovery of epinephrine in urine sample diluted 5 times with buffer solution was $101.5({\pm}3.2)%$ for 6 measurements.
Keywords
Catecholamines; Epinephrine; Ni(II)-macrocyclic complex; Polyurethane; Polymer-modified electrode;
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