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Accumulation Property in Human Body of Benzene Derived from Groundwater According to Exposure Pathway  

김상준 (한국과학기술원 생명화학공학과 환경복원공학연구실)
이현호 (LG 환경안전연구원)
박지연 (한국과학기술원 생명화학공학과 환경복원공학연구실)
이유진 (한국과학기술원 생명화학공학과 환경복원공학연구실)
유동한 (한국원자력연구소)
양지원 (한국과학기술원 생명화학공학과 환경복원공학연구실)
Publication Information
Journal of Soil and Groundwater Environment / v.9, no.1, 2004 , pp. 12-27 More about this Journal
Abstract
The contamination pattern of indoor air was simulated when groundwater dissolving benzene was used for household activities. Indoor exposure scenario consisted of inhalation, ingestion, and dermal absorption. Physiologically based pharmacokinetic (PBPK) model was used to analyze how benzene exposed to human body was distributed in internal organs. Main exposure pathways contributing total internal dose were inhalation and ingestion while the contribution of dermal absorption was very small. Man showed higher exposure rate than woman due to his higher breath rate. For a short-term exposure, benzene concentration in venous blood of SPT, RPT and liver changed rapidly while slowly did in venous blood of adipose tissue at a low concentration. For a long-term exposure, woman accumulated about 2.1 times higher than man. Most of benzene exposed to human body was removed by exhalation and metabolism at lung and liver, respectively. For inhalation and ingestion, the benzene removals by exhalation were 69.8 and 48.4%, respectively. Relative importance of removal mechanism was different according to the inflow displacement of benzene. The results obtained from this study would help understand exposure, distribution, and removal phenomena and make plans for the reduction of the health risk associated with the contaminated groundwater by various organic compounds.
Keywords
Groundwater; PBPK model; Benzene; Human exposure;
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