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http://dx.doi.org/10.6564/JKMRS.2022.26.4.059

NMR-based metabolic responses of the zebrafish exposed to Benzo[a]pyrene

Sujin, Lee (Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University)
Seonghye, Kim (Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University)
Suhkmann, Kim (Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University)

Publication Information

Journal of the Korean Magnetic Resonance Society / v.26, no.4, 2022 , pp. 59-65 More about this Journal

Abstract

Benzo[a]pyrene (BaP), one of the polycyclic aromatic hydrocarbons (PAHs), is an endocrine disruptor and carcinogenic. This study was conducted to investigate the metabolic changes of zebrafish short-term exposure to BaP using nuclear magnetic resonance (NMR) spectroscopy. In our results, the multivariate analysis showed that the metabolic responses were differed according to the exposure concentration. Also, it was observed that exposure to high concentration of BaP (162 ㎍/L and 1620 ㎍/L) increased the levels of creatine, histidine, and inosine in zebrafish, which means high concentration of BaP exposure affected the energy metabolism and immune function in zebrafish.

Keywords

zebrafish; benzo[a]pyrene; PAHs; metabolomics; NMR;

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Times Cited By KSCI : 1 (Citation Analysis)

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