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High-pressure NMR application for amyloid-beta peptides  

Kim, Jin Hae (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST))
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Journal of the Korean Magnetic Resonance Society / v.26, no.1, 2022 , pp. 17-20 More about this Journal
High-pressure (HP) NMR is a versatile tool to investigate diverse features of proteins. This technique has been particularly powerful to elucidate structural dynamics that only populates sufficiently in a pressurized condition. Amyloidogenic proteins, which are prone to aggregate and form amyloid fibrils, often maintains highly dynamic states in its native or aggregation-prone states, and HP NMR contributed much to advance our understandings of the dynamic behaviors of amyloidogenic proteins and the molecular mechanisms of their aggregation. In this mini review, we therefore summarize recent HP NMR studies on amyloid-beta (Aβ), the representative amyloidogenic intrinsically disordered protein (IDP).
high-pressure NMR; amyloid-beta; protein aggregation; protein dynamics; NMR spectroscopy;
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