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http://dx.doi.org/10.6564/JKMRS.2017.21.1.026

Elucidating the Dynamic Properties of Globular Protein using Predicted Order Parameters and 15N NMR Relaxation  

Yi, Jong-Jae (College of pharmacy, CHA University)
Kim, Won-Je (College of pharmacy, Seoul National University)
Rhee, Jin-Kyu (Department of Food Science and Engineering, Ewha Womans University)
Lim, Jongsoo (Discovery Technology Team, Dong-A ST Research Institute)
Lee, Bong-Jin (College of pharmacy, Seoul National University)
Son, Woo Sung (College of pharmacy, CHA University)
Publication Information
Journal of the Korean Magnetic Resonance Society / v.21, no.1, 2017 , pp. 26-30 More about this Journal
Abstract
Dynamic properties of proteins can present key information on protein-ligand and protein-protein interaction. Despite their usefulness, the properties of protein dynamics have not been obtained easily due to protein stability and short-term measurement. Here, it is shown that combined method for analysis of dynamical properties. It utilizes predicted order parameter and NMR relaxation data such as $T_1$, $T_2$, and heteronuclear NOE. The suggested method could be used to know the flexibility of protein roughly without precise dynamical parameters such as order parameters through model-free analysis.
Keywords
Dynamics; Relaxation; Protein; Order Parameter; Structure; NMR; Pyrazinamidase;
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Times Cited By KSCI : 2  (Citation Analysis)
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