Browse > Article
http://dx.doi.org/10.6564/JKMRS.2011.15.2.090

1H NMR-based metabolomic study of Cornus officinalis from different geographical origin  

Jung, Young-Ae (Seoul Center, Korea Basic Science Institute)
Jung, Young-Sang (Seoul Center, Korea Basic Science Institute)
Hwang, Geum-Sook (Seoul Center, Korea Basic Science Institute)
Publication Information
Journal of the Korean Magnetic Resonance Society / v.15, no.2, 2011 , pp. 90-103 More about this Journal
Abstract
Cornus officinalis (Cornaceae) is primarily grown in Asian countries. The pericarp of C. officinalis (Corni Fructus) is a well-known traditional medicine with tonic, analgesic, and diuretic properties. We analyzed methanolic extracts of Corni Fructus (grown in Korea and China) by $^1H$ NMR spectroscopy. Metabolite profiling was performed to characterize the metabolic difference between different Corni Fructus origins (Korea or China). Principal components analysis revealed significant separation between Comus Fructus from different origins. The metabolites responsible for differences were identified using loading plots, coefficients plots, and variable influence on projection followed by t-tests. As a result, 16 metabolites were identified and quantified; tyrosine, acetate, sucrose, and malate differed the most between origins. These data suggest that NMR-based metabolomics can be used to identify differences between Corni Fructus samples obtained from different regions.
Keywords
Metabolomics; $^1H$ NMR; Multivariate analysis; Cornus officinalis; Geographical origin;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 S. Rochfort, J. Nat. Prod. 68, 1813, (2005).   DOI
2 R. D. Hall, New Phytol. 169, 453, (2006).   DOI
3 R. Verpoorte, Y. H. Choi, H. K. Kim, Phytochem. Rev. 6, 3, (2007).   DOI
4 C. Seger S. Sturm, J. Proteome Res. 6, 480, (2007).   DOI
5 H. K. Kim, Y. H. Choi, R. Verpoorte, Nat. Protocols 5, 536, (2010).   DOI   ScienceOn
6 T. Skov, F. van den Berg, G. Tomasi, R. Bro, J. Chemom. 20, 484, (2006).   DOI
7 Y. S. Hong, Y. T. Ahn, J. C. Park, J. H. Lee, H. Lee, C. S. Huh, D. H. Kim, D. H. Ryu, G. S. Hwang, Arch. Pharm. Res. 33, 1091, (2010).   DOI
8 H. K. Choi, Y. H. Choi, M. Verberne, A. W. M. Lefeber, C. Erkelens, R. Verpoorte, Phytochemistry 65, 857, (2004).   DOI
9 H. Grove, B. M. Jorgensen, F. Jessen, I. Sondergaard, S. Jacobsen, K. Hollung, U. Indahl, E. M. Faergestad, J. Proteome Res. 7, 5119, (2008).   DOI
10 J. Y. Jung, H. S. Lee, D. G. Kang, N. S. Kim, M. H. Cha, O. S. Bang, D. H. Ryu, G. S. Hwang, Stroke 42, 1282, (2011).   DOI
11 S. Asikainen, B. Dogan, Z. Turgut, B. J. Paster, A. Bodur, J. Oscarsson, PLoS ONE 5, E13589, (2010).   DOI
12 J. Lee, D. S. Jang, N. H. Kim, Y. M. Lee, J. Kim, J. S. Kim, Biol. Pharm. Bull. 34, 443, (2011).   DOI
13 K. Y. Lee, S. H. Sung, S. H. Kim, Y. P. Jang, T. H. Oh, Y. C. Kim, Arch. Pharm. Res. 32, 677, (2009).   DOI
14 N. Yamabe, K. S. Kang, E. Goto, T. Tanaka, T. Yokozawa, Biol. Pharm. Bull. 30, 520, (2007).   DOI
15 Y. K. Park, W. K. Whang, H. I. Kin, Chung-Ang J. Pharm. Sci. 9, 5, (1995).
16 N. T. Telang, G. Li, D. W. Sepkovic, H. L. Bradlow, G. Y. C. Wong, Mol. Med. Rep. 5, 22, (2012).
17 T. Wang, Y. Pan, F. Yin, H. Q. Xu, T. H. Fang, B.C. Cai, Chinese J. Nanjing Univ. TCM 15, 345,(1999).
18 L. W. Sumner, P. Mendes, R. A. Dixon, Phytochemistry 62, 81, (2003).
19 O. Fiehn, J. Kopka, P. Dormann, T. Altmann, R. N. Trethewey, L. Willmitzer, Nature Biotechnol. 18, 1157, (2000).   DOI