[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.6564/JKMRS.2011.15.2.128

A new derivative of phorbaketals isolated from a Marine Sponge Phorbas species

Hwang, Buyng-Su (Department of Oceanography, Kunsan National University)
Yang, Cao (Department of Oceanography, Kunsan National University)
Rho, Jung-Rae (Department of Oceanography, Kunsan National University)

Publication Information

Journal of the Korean Magnetic Resonance Society / v.15, no.2, 2011 , pp. 128-136 More about this Journal

Abstract

A new sesterterpenoid, phorbaketal derivative, was isolated from the marine sponge Phorbas species. Its planar structures was completely determined from a combination of extensive 1D and 2D NMR experiments and MS data, and also the stereochemistry on the chiral centers were established by the ROESY experiment and the comparison with the $^1H$ and $^{13}C$ chemical shifts of the known phorbaketal compounds. This compound 1 moderately showed cytotoxicity effect against hepatoma cancer HepG2 cell.

Keywords

1D and 2D NMR; Phorbaketal; sponge Phorbas sp.; cytotoxicity;

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